Annotations: 8VYQ

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	14-3-3 protein zeta/delta	protein binding binding protein domain specific binding phosphoprotein binding phosphoserine residue binding protein phosphorylated amino acid binding molecular sequestering activity protein sequestering activity RNA binding nucleic acid binding transmembrane transporter binding kinase binding enzyme binding protein kinase binding protein binding binding protein domain specific binding phosphoprotein binding phosphoserine residue binding protein phosphorylated amino acid binding molecular sequestering activity protein sequestering activity RNA binding nucleic acid binding transmembrane transporter binding kinase binding enzyme binding protein kinase binding cell adhesion molecule binding cadherin binding transcription factor binding DNA-binding transcription factor binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding identical protein binding	Golgi localization establishment of organelle localization localization cellular localization establishment of Golgi localization organelle localization establishment of localization in cell cellular process establishment of localization protein localization cellular macromolecule localization macromolecule localization developmental process multicellular organismal process Golgi localization establishment of organelle localization localization cellular localization establishment of Golgi localization organelle localization establishment of localization in cell cellular process establishment of localization protein localization cellular macromolecule localization macromolecule localization developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development blood vessel development system development regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress response to starvation cellular response to glucose starvation cellular response to starvation signaling intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade ERK1 and ERK2 cascade signal transduction regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms negative regulation of response to biotic stimulus regulation of response to external stimulus response to biotic stimulus regulation of response to stress innate immune response regulation of immune system process response to external biotic stimulus negative regulation of response to stimulus immune response response to other organism defense response regulation of innate immune response negative regulation of immune response defense response to symbiont response to external stimulus regulation of response to stimulus negative regulation of immune system process immune system process defense response to other organism negative regulation of response to external stimulus negative regulation of defense response regulation of immune response negative regulation of innate immune response animal organ development respiratory tube development lung development respiratory system development Golgi inheritance organelle inheritance Golgi reassembly cellular component organization cellular component biogenesis organelle organization cellular component assembly cellular component organization or biogenesis Golgi organization endomembrane system organization regulation of cellular component organization regulation of developmental process nervous system development developmental maturation synapse maturation regulation of synapse organization regulation of synapse maturation cell junction organization regulation of synapse structure or activity synapse organization regulation of biological quality regulation of protein stability system process respiratory system process respiratory gaseous exchange by respiratory system protein phosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process establishment of protein localization protein targeting regulation of signaling regulation of signal transduction regulation of MAPK cascade regulation of intracellular signal transduction regulation of cell communication regulation of ERK1 and ERK2 cascade negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of cell communication negative regulation of TORC1 signaling negative regulation of TOR signaling regulation of TORC1 signaling TOR signaling regulation of TOR signaling negative regulation of signal transduction TORC1 signaling neuron recognition cellular developmental process cell development synaptic target recognition generation of neurons neurogenesis neuron differentiation cell differentiation neuron development cell recognition regulation of localization regulation of protein localization regulation of protein localization to nucleus protein localization to nucleus negative regulation of protein localization to nucleus regulation of cellular localization protein localization to organelle negative regulation of protein localization RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process tube formation	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen synapse glutamatergic synapse blood microparticle neuron to neuron synapse hippocampal mossy fiber to CA3 synapse
C	Serine/threonine-protein kinase B-raf	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity DNA-dependent protein kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity DNA-dependent protein kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-containing complex binding MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity histone H3T6 kinase activity histone H3 kinase activity histone modifying activity histone kinase activity histone H3S57 kinase activity cation binding calcium ion binding metal ion binding scaffold protein binding protein binding histone H4S1 kinase activity histone H4 kinase activity histone H3T11 kinase activity histone H3S28 kinase activity histone H2B kinase activity histone H2BS36 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity histone H2AS121 kinase activity histone H2A kinase activity AMP-activated protein kinase activity kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase kinase binding MAP kinase kinase kinase activity histone H3T45 kinase activity eukaryotic translation initiation factor 2alpha kinase activity histone H3T3 kinase activity histone H2BS14 kinase activity identical protein binding Rho-dependent protein serine/threonine kinase activity histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity protein serine kinase activity 3-phosphoinositide-dependent protein kinase activity transition metal ion binding zinc ion binding histone H2AS1 kinase activity	regulation of localization regulated exocytosis regulation of cellular process synaptic vesicle cycle negative regulation of biological process synaptic vesicle exocytosis negative regulation of transport vesicle-mediated transport cell communication vesicle-mediated transport in synapse localization negative regulation of secretion establishment of localization in cell negative regulation of secretion by cell regulation of localization regulated exocytosis regulation of cellular process synaptic vesicle cycle negative regulation of biological process synaptic vesicle exocytosis negative regulation of transport vesicle-mediated transport cell communication vesicle-mediated transport in synapse localization negative regulation of secretion establishment of localization in cell negative regulation of secretion by cell trans-synaptic signaling regulation of biological process neurotransmitter secretion regulation of synaptic vesicle exocytosis neurotransmitter transport establishment of localization negative regulation of synaptic vesicle exocytosis regulation of secretion signal release from synapse regulation of trans-synaptic signaling exocytosis cellular localization transport modulation of chemical synaptic transmission signaling negative regulation of regulated secretory pathway regulation of regulated secretory pathway synaptic signaling regulation of secretion by cell secretion by cell negative regulation of exocytosis signal release negative regulation of cellular process regulation of signaling regulation of transport secretion regulation of neurotransmitter transport biological regulation export from cell cell-cell signaling regulation of vesicle-mediated transport chemical synaptic transmission regulation of neurotransmitter secretion anterograde trans-synaptic signaling regulation of exocytosis regulation of cell communication cellular process developmental process anatomical structure morphogenesis head development anatomical structure development head morphogenesis body morphogenesis cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion positive regulation of cell-substrate adhesion multicellular organismal process regulation of leukocyte differentiation cellular developmental process regulation of developmental process regulation of leukocyte activation cell development regulation of cell activation mononuclear cell differentiation regulation of cell differentiation lymphocyte activation lymphocyte differentiation regulation of cell development leukocyte activation regulation of T cell differentiation multicellular organism development T cell activation cell differentiation T cell differentiation regulation of immune system process regulation of multicellular organismal process regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis cell activation regulation of T cell activation immune system process regulation of hemopoiesis leukocyte differentiation regulation of lymphocyte activation cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to stimulus response to metal ion response to chemical cellular response to calcium ion response to calcium ion somatic stem cell population maintenance maintenance of cell number stem cell population maintenance cellular response to xenobiotic stimulus response to xenobiotic stimulus response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to purine-containing compound response to cAMP positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling thyroid gland development endocrine system development gland development animal organ development system development negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death myeloid progenitor cell differentiation hematopoietic progenitor cell differentiation cell population proliferation regulation of cell population proliferation negative regulation of endothelial cell apoptotic process endothelial cell apoptotic process regulation of endothelial cell apoptotic process CD4-positive, alpha-beta T cell differentiation alpha-beta T cell differentiation CD4-positive, alpha-beta T cell activation alpha-beta T cell activation positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process positive regulation of cellular component organization regulation of actin filament bundle assembly cellular component biogenesis cellular component organization cellular component assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly actin filament-based process cellular component organization or biogenesis stress fiber assembly regulation of actin filament organization actin cytoskeleton organization actomyosin structure organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization actin filament organization regulation of cellular component biogenesis positive regulation of supramolecular fiber organization regulation of organelle organization regulation of stress fiber assembly organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization regulation of actin cytoskeleton organization actin filament bundle assembly regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization cell projection organization positive regulation of neuron projection regeneration regulation of cellular response to stress neuron projection development regeneration neuron projection regeneration positive regulation of developmental process neuron differentiation positive regulation of cell projection organization response to wounding positive regulation of response to wounding regulation of axon regeneration regulation of cell projection organization response to external stimulus nervous system development generation of neurons regulation of neuron projection regeneration regulation of neuron projection development regulation of response to external stimulus response to axon injury regulation of response to wounding neurogenesis positive regulation of response to external stimulus cellular response to stress axon regeneration positive regulation of neuron projection development regulation of response to stress response to stress plasma membrane bounded cell projection organization axon development neuron development positive regulation of axon regeneration regulation of plasma membrane bounded cell projection organization CD4-positive or CD8-positive, alpha-beta T cell lineage commitment T cell lineage commitment positive T cell selection T cell selection cell fate commitment regulation of biosynthetic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process positive regulation of nervous system development axonogenesis regulation of neurogenesis cell projection morphogenesis neuron projection morphogenesis positive regulation of cell development positive regulation of multicellular organismal process plasma membrane bounded cell projection morphogenesis cell morphogenesis regulation of nervous system development positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis positive regulation of axonogenesis regulation of anatomical structure morphogenesis cell morphogenesis involved in neuron differentiation cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus response to nerve growth factor response to growth factor T cell differentiation in thymus postsynaptic modulation of chemical synaptic transmission cell surface receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway ERBB signaling pathway epidermal growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway negative regulation of locomotion regulation of cell motility regulation of fibroblast migration fibroblast migration negative regulation of fibroblast migration regulation of locomotion ameboidal-type cell migration regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion face development response to hormone response to peptide hormone immune response-regulating cell surface receptor signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response positive regulation of immune system process immune response-activating cell surface receptor signaling pathway immune response T cell receptor signaling pathway regulation of immune response antigen receptor-mediated signaling pathway activation of immune response immune system development hematopoietic or lymphoid organ development thymus development animal organ morphogenesis response to light stimulus system process learning learning or memory nervous system process visual learning visual behavior cognition associative learning behavior response to radiation response to abiotic stimulus neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process protein localization establishment of protein localization establishment of protein localization to membrane localization within membrane protein localization to membrane cellular macromolecule localization macromolecule localization hexose transmembrane transport carbohydrate transport positive regulation of D-glucose transmembrane transport transmembrane transport regulation of transmembrane transport positive regulation of transport D-glucose transmembrane transport positive regulation of transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport long-term synaptic potentiation regulation of biological quality regulation of synaptic plasticity positive regulation of synaptic transmission	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell body membrane-bounded organelle intracellular membraneless organelle cilium plasma membrane bounded cell projection intracellular organelle ciliary basal body cell projection microtubule organizing center cytoskeleton cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell body membrane-bounded organelle intracellular membraneless organelle cilium plasma membrane bounded cell projection intracellular organelle ciliary basal body cell projection microtubule organizing center cytoskeleton organelle membraneless organelle microtubule cytoskeleton cell periphery plasma membrane membrane intracellular membrane-bounded organelle synapse cell junction glutamatergic synapse neuron projection postsynapse mitochondrion centrosome centriolar satellite presynapse nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR023409	14-3-3 protein, conserved site	Conserved Site
A, B	IPR023410	14-3-3 domain	Domain
A, B	IPR036815	14-3-3 domain superfamily	Homologous Superfamily
A, B	IPR000308	14-3-3 protein	Family
C	IPR020454	Diacylglycerol/phorbol-ester binding	Domain
C	IPR000719	Protein kinase domain	Domain
C	IPR017441	Protein kinase, ATP binding site	Binding Site
C	IPR051681	Serine/Threonine Kinases and Pseudokinases	Family
C	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
C	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Domain
C	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
C	IPR046349	C1-like domain superfamily	Homologous Superfamily
C	IPR008271	Serine/threonine-protein kinase, active site	Active Site
C	IPR003116	Raf-like Ras-binding	Domain
C	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P63104	Mammary Neoplasms, Experimental Parkinson disease carcinoma sarcomatoid carcinoma mammary neoplasms, animal myopathy ovarian cancer paranoid schizophrenia plasma cell myeloma atypical teratoid rhabdoid tumor undifferentiated carcinoma breast carcinoma Creutzfeldt Jacob disease invasive ductal breast carcinoma lung adenocarcinoma Mammary Neoplasms, Experimental Parkinson disease carcinoma sarcomatoid carcinoma mammary neoplasms, animal myopathy ovarian cancer paranoid schizophrenia plasma cell myeloma atypical teratoid rhabdoid tumor undifferentiated carcinoma breast carcinoma Creutzfeldt Jacob disease invasive ductal breast carcinoma lung adenocarcinoma malignant glioma pancreatic ductal adenocarcinoma primitive neuroectodermal tumor bipolar disorder glioblastoma large cell medulloblastoma lung cancer medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma astrocytic tumor breast cancer IgA glomerulonephritis malignant ependymoma
C	Pharos: P15056	cardiofaciocutaneous syndrome Noonan syndrome Noonan syndrome with multiple lentigines malignant glioma colorectal cancer Noonan syndrome 7 gastrointestinal stromal tumor Costello syndrome Erdheim-Chester disease melanoma craniopharyngioma pilocytic astrocytoma ameloblastoma cancer hairy cell leukemia cardiofaciocutaneous syndrome Noonan syndrome Noonan syndrome with multiple lentigines malignant glioma colorectal cancer Noonan syndrome 7 gastrointestinal stromal tumor Costello syndrome Erdheim-Chester disease melanoma craniopharyngioma pilocytic astrocytoma ameloblastoma cancer hairy cell leukemia adrenal cortex carcinoma subependymal giant cell astrocytoma LEOPARD syndrome 3 lung cancer astrocytic tumor cardiomyopathy hepatocellular carcinoma protoplasmic astrocytoma mixed glioma Neoplasms, Experimental fibrillary astrocytoma childhood cerebral astrocytoma plasma cell myeloma prostate cancer intellectual disability adamantinous craniopharyngioma juvenile pilocytic astrocytoma cutaneous melanoma Sezary syndrome Langerhans cell histiocytosis anaplastic astrocytoma neuroendocrine neoplasm thyroid gland carcinoma cardiofaciocutaneous syndrome 1 gemistocytic astrocytoma cholangiocarcinoma papillary craniopharyngioma Hashimoto-Pritzker syndrome primary cutaneous T-cell non-Hodgkin lymphoma thyroid adenoma liver cancer Noonan syndrome 1 gastric neoplasm oligodendroglioma glioblastoma childhood brain stem glioma ovarian carcinoma granulomatous slack skin disease chronic myelogenous leukemia, BCR-ABL1 positive mandibular cancer prostate adenocarcinoma hypertrophic cardiomyopathy adamantinoma congenital anemia adrenal carcinoma kidney neoplasm stomach carcinoma in situ large congenital melanocytic nevus astrocytoma (excluding glioblastoma) benign neoplasm of stomach thyroid cancer breast adenocarcinoma non-Hodgkin lymphoma lung benign neoplasm nongerminomatous germ cell tumor type 2 diabetes mellitus malignant colon neoplasm cerebral astrocytoma osteosarcoma glioma ovarian neoplasm colon carcinoma histiocytosis colorectal carcinoma psoriasis atypical teratoid rhabdoid tumor thyroid cancer, nonmedullary, 1 liver neoplasm breast carcinoma non-Langerhans cell histiocytosis familial nonmedullary thyroid carcinoma gastric carcinoma tuberculosis lymphoma, non-Hodgkin, familial malignant ependymoma Charcot-Marie-Tooth disease ovarian cancer colorectal adenocarcinoma hydrops fetalis interstitial cystitis renal cell carcinoma kidney cancer cystadenoma spina bifida large cell medulloblastoma B-cell chronic lymphocytic leukemia diffuse astrocytoma neurofibromatosis type 1 exocrine pancreatic carcinoma thyroid cancer, nonmedullary, 2 lung adenocarcinoma non-small cell lung carcinoma thyroid gland papillary carcinoma lung carcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.