SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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112 entries where SER is found as a standalone ligand51 entries where SER is covalently linked to polymer or other heterogen groups 228,135 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00133 ?
Name	Serine
Groups	investigational nutraceutical
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	Serina L-Serine Serinum Serine (S)-Serine Ser (S)-2-Amino-3-hydroxypropanoic acid alpha-Amino-beta-hydroxypropionic acid beta-Hydroxyalanine
Brand Names	Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Aminosyn II In Dextrose Injection RenAmin Vamin N Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn II Aminosyn II 7% Injection Primene 10% Aminosyn II in Dextrose 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Renamin (amino Acids) Injection Vamin 18 Electrolyte-free Novamine Aminosyn 3.5% M Aminosyn II with Electrolytes Clinimix E Aminosyn II 8.5% Injection 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Olimel 4.4% 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Periolimel 2.5% E 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn 8.5% Injection With Electrolytes 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn II with Electrolytes in Dextrose with Calcium 8.5% Freamine III Olimel 3.3% E Aminosyn 8.5% Clinisol Olimel 7.6% Smofkabiven Aminosyn HF Aminosyn II and Dextrose Aminosyn-PF 7% 20% Prosol ProSol Aminosyn 5% Smofkabiven Peripheral FreAmine III HepatAmine 2.75% Travas. Amino Acid InJ.W.elecw.25%dex 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Plenamine 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Travasol Olimel 5.7% Olimel 5.7% E Synthamin Aminosyn II 7% With 50% Dextrose Smofkabiven Extra Nitrogen Perikabiven Nutrineal Pd4 Essepna Aminosyn-PF 10% 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn II 10% With Electrolytes Aminosyn Sulfite Free Aminosyn 10% W Electrolytes Aminosyn-PF Clinimix Primene ProcalAmine Smofkabiven Electrolyte Free Kabiven Aminosyn II 8.5% With 50% Dextrose TrophAmine Olimel 7.6% E 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Olimel 4.4% E Aminosyn II 5% Inj Primene 10%-liq IV Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Hepatasol Aminosyn 7% 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Aminosyn Aminosyn II 7% With 10% Dextrose Premasol - sulfite-free (Amino Acid) Aminosyn II 7% M In 10% Dextrose(dual Chamber) FreAmine HBC
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	5951, 6857581
ChEMBL	CHEMBL11298
ChEBI	CHEBI:33384, CHEBI:17115
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01