SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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113 entries where SER is found as a standalone ligand51 entries where SER is covalently linked to polymer or other heterogen groups 230,391 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00133 ?
Name	Serine
Groups	nutraceutical investigational
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	Serine (S)-2-Amino-3-hydroxypropanoic acid Ser (S)-Serine Serina beta-Hydroxyalanine alpha-Amino-beta-hydroxypropionic acid L-Serine Serinum
Brand Names	8.5% Freamine III Kabiven Aminosyn II Smofkabiven Novamine 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Perikabiven Aminosyn 3.5% M 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminosyn II 8.5% Injection Aminosyn II 10% With Electrolytes 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn-PF Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Aminosyn II with Electrolytes Aminosyn-PF 7% Clinimix E Olimel 7.6% E Travasol Plenamine Aminosyn 7% Aminosyn II 7% With 10% Dextrose Aminosyn II 5% Inj Hepatasol Aminosyn Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn 5% Clinisol 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose FreAmine HBC Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn HF Aminosyn-PF 10% 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Aminosyn II 8.5% With 50% Dextrose Aminosyn 10% W Electrolytes Synthamin RenAmin Primene 10%-liq IV 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Vamin N Aminosyn II 7% With 50% Dextrose 20% Prosol ProSol Aminosyn Sulfite Free ProcalAmine Aminosyn II with Electrolytes in Dextrose with Calcium 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Vamin 18 Electrolyte-free Olimel 4.4% E Clinimix 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Olimel 7.6% FreAmine III Olimel 5.7% TrophAmine Olimel 3.3% E Aminosyn II in Dextrose 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Primene 10% Nutrineal Pd4 HepatAmine Aminosyn II 7% M In 10% Dextrose(dual Chamber) Olimel 5.7% E Smofkabiven Extra Nitrogen Essepna Aminosyn 8.5% Renamin (amino Acids) Injection Premasol - sulfite-free (Amino Acid) Aminosyn II and Dextrose Smofkabiven Electrolyte Free Primene Periolimel 2.5% E Smofkabiven Peripheral Aminosyn II In Dextrose Injection 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Olimel 4.4% Aminosyn II 7% Injection Aminosyn 8.5% Injection With Electrolytes 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	6857581, 5951
ChEMBL	CHEMBL11298
ChEBI	CHEBI:17115, CHEBI:33384
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01