8ZZI | pdb_00008zzi

The molecular architecture of the BBSome and its implications for facilitated transition zone crossing

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
1	BBS1	phosphoprotein binding protein binding binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding patched binding signaling receptor binding smoothened binding G protein-coupled receptor binding	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane localization within membrane protein localization to membrane establishment of localization vesicle-mediated transport to the plasma membrane protein transport macromolecule localization cellular process Golgi vesicle transport protein localization to cilium protein localization to organelle head development forebrain development brain development nervous system development pallium development central nervous system development telencephalon development hippocampus development limbic system development sexual reproduction reproductive process fertilization sensory organ development eye development retina development in camera-type eye visual system development camera-type eye development sensory system development system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of smell brain morphogenesis anatomical structure morphogenesis animal organ morphogenesis behavior adult behavior regulation of hormone levels biological regulation metabolic process regulation of biological quality hormone metabolic process primary metabolic process lipid metabolic process regulation of biological process regulation of cellular process regulation of cell motility regulation of microtubule-based process regulation of microtubule-based movement cilium movement involved in cell motility regulation of cilium-dependent cell motility cilium or flagellum-dependent cell motility regulation of cilium movement cilium-dependent cell motility regulation of cilium beat frequency regulation of locomotion regulation of cilium beat frequency involved in ciliary motility microtubule-based movement microtubule-based process regulation of cilium movement involved in cell motility cilium movement cell motility locomotion organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization organelle organization cellular component assembly cilium assembly cellular component organization or biogenesis non-motile cilium assembly cilium organization cell projection assembly cerebral cortex development cellular developmental process cell development neuron projection development generation of neurons neurogenesis neuron differentiation dendrite development cell differentiation neuron development multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis retina homeostasis photoreceptor cell maintenance photoreceptor cell differentiation cell morphogenesis involved in neuron differentiation cell morphogenesis photoreceptor cell morphogenesis photoreceptor cell development cell population proliferation neural precursor cell proliferation fat cell differentiation microtubule cytoskeleton organization cytoskeleton organization striatum development subpallium development neuron migration cell migration response to stimulus olfactory behavior response to chemical chemosensory behavior ventricular system development cellular response to stimulus cellular response to stress response to stress response to endoplasmic reticulum stress	intracellular anatomical structure intracellular membraneless organelle intracellular organelle centrosome microtubule organizing center cellular anatomical structure cytoskeleton centriolar satellite organelle membraneless organelle microtubule cytoskeleton membrane-bounded organelle cell projection protein-containing complex intracellular anatomical structure intracellular membraneless organelle intracellular organelle centrosome microtubule organizing center cellular anatomical structure cytoskeleton centriolar satellite organelle membraneless organelle microtubule cytoskeleton membrane-bounded organelle cell projection protein-containing complex BBSome cilium plasma membrane bounded cell projection motile cilium membrane plasma membrane ciliary membrane cell periphery bounding membrane of organelle plasma membrane region organelle membrane cell projection membrane
2	BBS2	-	organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization organelle organization cellular component assembly cilium assembly cellular process cellular component organization or biogenesis non-motile cilium assembly cilium organization cell projection assembly	intracellular anatomical structure intracellular membraneless organelle intracellular organelle centrosome microtubule organizing center cellular anatomical structure cytoskeleton centriolar satellite organelle membraneless organelle microtubule cytoskeleton membrane-bounded organelle cell projection protein-containing complex intracellular anatomical structure intracellular membraneless organelle intracellular organelle centrosome microtubule organizing center cellular anatomical structure cytoskeleton centriolar satellite organelle membraneless organelle microtubule cytoskeleton membrane-bounded organelle cell projection protein-containing complex BBSome cilium plasma membrane bounded cell projection cytoplasm membrane plasma membrane ciliary membrane cell periphery bounding membrane of organelle plasma membrane region organelle membrane cell projection membrane
4	BBS4	protein-macromolecule adaptor activity molecular adaptor activity	protein localization localization cellular localization protein localization to cilium protein localization to organelle cellular macromolecule localization macromolecule localization cellular process microtubule organizing center organization microtubule cytoskeleton organization cellular component organization organelle organization centrosome cycle microtubule-based process protein localization localization cellular localization protein localization to cilium protein localization to organelle cellular macromolecule localization macromolecule localization cellular process microtubule organizing center organization microtubule cytoskeleton organization cellular component organization organelle organization centrosome cycle microtubule-based process cell cycle cellular component organization or biogenesis cytoskeleton organization cell cycle process establishment of protein localization nitrogen compound transport transport establishment of localization protein transport organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly cilium assembly cilium organization cell projection assembly	membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton pericentriolar material centriolar satellite cytoplasm motile cilium ciliary basal body membrane plasma membrane ciliary membrane cell periphery bounding membrane of organelle plasma membrane region organelle membrane cell projection membrane
5	BBS5	binding phospholipid binding lipid binding phosphatidylinositol-3-phosphate binding phosphatidylinositol phosphate binding phosphatidylinositol binding	localization cellular localization transport establishment of localization in cell intracellular transport cellular process establishment of localization protein localization establishment of protein localization nitrogen compound transport protein transport cellular macromolecule localization macromolecule localization organelle assembly localization cellular localization transport establishment of localization in cell intracellular transport cellular process establishment of localization protein localization establishment of protein localization nitrogen compound transport protein transport cellular macromolecule localization macromolecule localization organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization organelle organization cellular component assembly cilium assembly cellular component organization or biogenesis cilium organization cell projection assembly	intracellular anatomical structure intracellular membraneless organelle intracellular organelle centrosome microtubule organizing center cellular anatomical structure cytoskeleton centriolar satellite organelle membraneless organelle microtubule cytoskeleton membrane-bounded organelle cell projection protein-containing complex intracellular anatomical structure intracellular membraneless organelle intracellular organelle centrosome microtubule organizing center cellular anatomical structure cytoskeleton centriolar satellite organelle membraneless organelle microtubule cytoskeleton membrane-bounded organelle cell projection protein-containing complex BBSome cilium plasma membrane bounded cell projection cytoplasm ciliary basal body membrane plasma membrane ciliary membrane cell periphery bounding membrane of organelle plasma membrane region organelle membrane cell projection membrane
7	BBS7	-	organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization organelle organization cellular component assembly cilium assembly cellular process cellular component organization or biogenesis non-motile cilium assembly cilium organization cell projection assembly organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization organelle organization cellular component assembly cilium assembly cellular process cellular component organization or biogenesis non-motile cilium assembly cilium organization cell projection assembly protein localization localization cellular localization cellular macromolecule localization macromolecule localization transport establishment of localization in cell intracellular transport establishment of localization establishment of protein localization nitrogen compound transport protein transport	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure axoneme ciliary plasm cilium intracellular membraneless organelle cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection intracellular organelle cell projection cytoskeleton cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure axoneme ciliary plasm cilium intracellular membraneless organelle cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection intracellular organelle cell projection cytoskeleton organelle membraneless organelle cytoplasm protein-containing complex BBSome ciliary basal body microtubule organizing center microtubule cytoskeleton neuron projection
8	BBS8	-	organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization organelle organization cellular component assembly cilium assembly cellular process cellular component organization or biogenesis non-motile cilium assembly cilium organization cell projection assembly	membrane-bounded organelle cell projection protein-containing complex cellular anatomical structure BBSome organelle cilium plasma membrane bounded cell projection
9	BBS9	-	protein localization localization cellular localization protein localization to cilium protein localization to organelle cellular macromolecule localization macromolecule localization cellular process	ciliary transition zone membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection intracellular anatomical structure intracellular membraneless organelle pericentriolar material intracellular organelle centrosome microtubule organizing center cytoskeleton ciliary transition zone membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection intracellular anatomical structure intracellular membraneless organelle pericentriolar material intracellular organelle centrosome microtubule organizing center cytoskeleton membraneless organelle microtubule cytoskeleton centriolar satellite cytoplasm cytosol protein-containing complex BBSome nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen ciliary basal body membrane plasma membrane ciliary membrane cell periphery bounding membrane of organelle plasma membrane region organelle membrane cell projection membrane
IP	BBS18	-	organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization organelle organization cellular component assembly cilium assembly cellular process cellular component organization or biogenesis cilium organization cell projection assembly	membrane-bounded organelle cell projection protein-containing complex cellular anatomical structure BBSome organelle cilium plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
1	IPR032728	Bardet-Biedl syndrome 1, N-terminal	Domain
1	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily	Homologous Superfamily
1	IPR028784	BBSome complex member BBS1	Family
1	IPR056419	Bardet-Biedl syndrome 1 protein, GAE domain	Domain
2	IPR055381	BBS2, C-terminal helix bundle domain	Domain
2	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
2	IPR029429	Ciliary BBSome complex subunit 2, middle region	Domain
2	IPR055380	BBS2, hairpin domain	Domain
2	IPR016616	Bardet-Biedl syndrome 2 protein	Family
2	IPR029430	Ciliary BBSome complex subunit 2, N-terminal	Domain
2	IPR029333	BBS2, GAE domain	Domain
2	IPR055379	BBS2, platform domain	Domain
4	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
4	IPR019734	Tetratricopeptide repeat	Repeat
5	IPR014003	BBSome complex member BBS5, PH domain	Domain
5	IPR006606	BBSome complex member BBS5	Family
5	IPR030804	BBSome complex member BBS5/sex-determination protein fem-3	Family
5	IPR011993	PH-like domain superfamily	Homologous Superfamily
7	IPR056332	BBS7, beta-propeller	Domain
7	IPR056334	BBS7, GAE domain	Domain
7	IPR056333	BBS7, platform domain	Domain
7	IPR016575	Bardet-Biedl syndrome 7 protein	Family
7	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
7	IPR056331	BBS7_C_hairpin	Unknown
7	IPR056335	BBS7, helical hairpin	Domain
7	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
8	IPR028796	Tetratricopeptide repeat protein 8	Family
8	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
8	IPR019734	Tetratricopeptide repeat	Repeat
9	IPR026511	Parathyroid hormone-responsive B1	Family
9	IPR055362	PTHB1, platform domain	Domain
9	IPR028074	PTHB1, GAE domain	Domain
9	IPR028073	PTHB1, N-terminal domain	Domain
9	IPR055363	PTHB1, hairpin domain	Domain
9	IPR055364	PTHB1, C-terminal helix bundle domain	Domain
IP	IPR028233	Cilia BBSome complex subunit 10	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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The molecular architecture of the BBSome and its implications for facilitated transition zone crossing

External Resource: Annotation

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage

8ZZI | pdb_00008zzi