8ZZC | pdb_00008zzc

Integrative structure and functional anatomy of eight spokes of a nuclear pore complex

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, BR, BY, CF, CM A, BR, BY, CF, CM, CT, DA, DH, DO, DV, EC, EJ, EQ, EX, FE, H	Nup84	structural molecule activity structural constituent of nuclear pore identical protein binding protein binding binding	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization subtelomeric heterochromatin formation regulation of cellular process negative regulation of biological process chromatin organization negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport intracellular transport establishment of localization RNA export from nucleus establishment of RNA localization macromolecule localization positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription silent mating-type cassette heterochromatin formation cellular response to stimulus double-strand break repair response to stimulus DNA metabolic process cellular response to stress DNA damage response response to stress DNA repair chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II response to heat response to temperature stimulus cellular response to heat response to nitrogen compound mRNA export from nucleus in response to heat stress response to chemical response to abiotic stimulus	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane membraneless organelle intracellular membraneless organelle chromosome chromosome, telomeric region chromosomal region
FP, FQ, FX, FY, GF FP, FQ, FX, FY, GF, GG, GN, GO, GV, GW, HD, HE, HL, HM, S, T	Nup159	transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity binding adenyl ribonucleotide binding nucleotide binding adenyl-nucleotide exchange factor activity ATPase regulator activity ATP-dependent activity purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity binding adenyl ribonucleotide binding nucleotide binding adenyl-nucleotide exchange factor activity ATPase regulator activity ATP-dependent activity purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding ADP binding anion binding adenyl nucleotide binding ATP binding molecular function regulator activity heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding structural molecule activity structural constituent of nuclear pore	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization metabolic process macromolecule metabolic process protein localization establishment of protein localization NLS-bearing protein import into nucleus protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus cellular component biogenesis ribosome biogenesis ribosomal small subunit export from nucleus organelle localization ribosome localization protein export from nucleus ribosomal large subunit export from nucleus	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel nuclear pore cytoplasmic filaments
AB, AF, AJ, FR, FS AB, AF, AJ, FR, FS, FZ, GA, GH, GI, GP, GQ, GX, GY, HF, HG, HN, HO, HR, HS, HZ, IA, IH, II, IP, IQ, IX, IY, JF, JG, JN, JO, JV, JW, KD, KE, KL, KM, KT, KU, LB, LC, LJ, LK, LR, LS, U, V, X	Nsp1	binding phospholipid binding lipid binding structural molecule activity structural constituent of nuclear pore	cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process protein localization establishment of protein localization NLS-bearing protein import into nucleus protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport tRNA export from nucleus tRNA transport establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus protein-containing complex localization cellular component biogenesis ribosome biogenesis ribosomal small subunit export from nucleus organelle localization cellular component organization or biogenesis ribosome localization ribosomal large subunit export from nucleus	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen nuclear pore nuclear basket
AA, AE, AI, HP, HQ AA, AE, AI, HP, HQ, HX, HY, IF, IG, IN, IO, IV, IW, JD, JE, JL, JM, JT, JU, KB, KC, KJ, KK, KR, KS, KZ, LA, LH, LI, LP, LQ, W	Nic96	structural molecule activity structural constituent of nuclear pore	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport establishment of localization nitrogen compound transport mRNA transport mRNA export from nucleus RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus gene expression macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization metabolic process macromolecule metabolic process establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus ribosomal large subunit export from nucleus protein-containing complex localization cellular component biogenesis ribosome biogenesis organelle localization ribosome localization protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane nuclear pore linkers nuclear pore nuclear basket
AC, AG, AK, HT, HU AC, AG, AK, HT, HU, IB, IC, IJ, IK, IR, IS, IZ, JA, JH, JI, JP, JQ, JX, JY, KF, KG, KN, KO, KV, KW, LD, LE, LL, LM, LT, LU, Y	Nup49	molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity RNA binding binding nucleic acid binding structural molecule activity structural constituent of nuclear pore identical protein binding protein binding nuclear localization sequence binding signal sequence binding peptide binding	localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell RNA localization localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process tRNA export from nucleus tRNA transport cellular component organization primary metabolic process protein metabolic process cellular component organization or biogenesis supramolecular fiber organization amyloid fibril formation organelle organization chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus ribosomal large subunit export from nucleus protein-containing complex localization cellular component biogenesis ribosome biogenesis ribosome localization protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel nuclear pore cytoplasmic filaments
AD, AH, AL, HV, HW AD, AH, AL, HV, HW, ID, IE, IL, IM, IT, IU, JB, JC, JJ, JK, JR, JS, JZ, KA, KH, KI, KP, KQ, KX, KY, LF, LG, LN, LO, LV, LW, Z	Nup57	structural molecule activity structural constituent of nuclear pore identical protein binding protein binding binding	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis protein localization establishment of protein localization cellular localization NLS-bearing protein import into nucleus nitrogen compound transport nucleocytoplasmic transport transport cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis protein localization establishment of protein localization cellular localization NLS-bearing protein import into nucleus nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport RNA transport nucleic acid transport mRNA transport establishment of RNA localization RNA localization nucleobase-containing compound transport localization within membrane protein localization to membrane protein localization to nuclear envelope protein localization to nuclear inner membrane	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel
AM, AQ, LX, MB, MF AM, AQ, LX, MB, MF, MJ, MN, MR, MV, MZ, ND, NH, NL, NP, NT, NX	Nup157	DNA binding binding nucleic acid binding RNA binding structural molecule activity structural constituent of nuclear pore	RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cellular component organization organelle organization chromosome organization RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cellular component organization organelle organization chromosome organization cellular process cellular component organization or biogenesis transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery cellular localization nucleocytoplasmic transport nuclear transport establishment of localization in cell intracellular transport protein localization protein localization to nucleus localization within membrane protein localization to membrane protein localization to nuclear envelope protein localization to organelle cellular macromolecule localization protein localization to nuclear inner membrane post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery nuclear pore organization protein-containing complex organization pore complex assembly cellular component biogenesis nuclear pore complex assembly nucleus organization cellular component assembly protein-containing complex assembly establishment of protein localization import into nucleus establishment of protein localization to organelle protein transport protein import into nucleus intracellular protein transport RNA export from nucleus nuclear export	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane nuclear pore inner ring membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane nuclear pore inner ring protein-containing complex nuclear protein-containing complex nuclear pore
AN, AR, LY, MC, MG AN, AR, LY, MC, MG, MK, MO, MS, MW, NA, NE, NI, NM, NQ, NU, NY	Nup170	protein-containing complex binding binding chromatin binding structural molecule activity structural constituent of nuclear pore promoter-specific chromatin binding	localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization establishment of RNA localization macromolecule localization RNA localization localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cellular component organization organelle organization chromosome organization cellular process cellular component organization or biogenesis transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery regulation of cellular process negative regulation of biological process chromatin organization negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process cell cycle chromosome segregation cell cycle process cellular localization nucleocytoplasmic transport nuclear transport establishment of localization in cell intracellular transport protein localization protein localization to nucleus localization within membrane protein localization to membrane protein localization to nuclear envelope protein localization to organelle cellular macromolecule localization protein localization to nuclear inner membrane nuclear pore organization protein-containing complex organization pore complex assembly cellular component biogenesis nuclear pore complex assembly nucleus organization cellular component assembly protein-containing complex assembly establishment of protein localization import into nucleus establishment of protein localization to organelle protein transport protein import into nucleus intracellular protein transport RNA export from nucleus nuclear export	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane nuclear pore inner ring membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane nuclear pore inner ring protein-containing complex nuclear protein-containing complex nuclear pore chromosome, subtelomeric region membraneless organelle intracellular membraneless organelle chromosome chromosome, telomeric region chromosomal region
AO, AS, LZ, MD, MH AO, AS, LZ, MD, MH, ML, MP, MT, MX, NB, NF, NJ, NN, NR, NV, NZ	Nup188	structural molecule activity structural constituent of nuclear pore	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport establishment of localization protein localization establishment of protein localization nitrogen compound transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport cellular response to stimulus response to stimulus response to heat mRNA transport response to temperature stimulus cellular response to stress mRNA export from nucleus response to stress RNA localization nuclear export nucleobase-containing compound transport cellular response to heat RNA transport nucleic acid transport response to nitrogen compound gene expression macromolecule biosynthetic process RNA export from nucleus mRNA export from nucleus in response to heat stress establishment of RNA localization biosynthetic process response to chemical metabolic process response to abiotic stimulus macromolecule metabolic process	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane nuclear pore inner ring membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane nuclear pore inner ring protein-containing complex nuclear protein-containing complex nuclear pore
AP, AT, MA, ME, MI AP, AT, MA, ME, MI, MM, MQ, MU, MY, NC, NG, NK, NO, NS, NW, OA	Nup192	structural molecule activity structural constituent of nuclear pore	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport establishment of localization regulation of localization regulation of biological process regulation of cellular process regulation of transport biological regulation regulation of nucleocytoplasmic transport regulation of cellular localization regulation of intracellular transport RNA transport nitrogen compound transport nucleic acid transport mRNA transport establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport protein localization establishment of protein localization protein transport cellular macromolecule localization	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear pore inner ring
AU, AZ, OB, OG, OL AU, AZ, OB, OG, OL, OQ, OV, PA, PF, PK, PP, PU, PZ, QE, QJ, QO	Nup53	binding phospholipid binding lipid binding structural molecule activity structural constituent of nuclear pore identical protein binding protein binding DNA binding single-stranded DNA binding nucleic acid binding	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis protein localization establishment of protein localization cellular localization NLS-bearing protein import into nucleus nitrogen compound transport nucleocytoplasmic transport transport cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis protein localization establishment of protein localization cellular localization NLS-bearing protein import into nucleus nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport regulation of cellular process regulation of protein modification process peptidyl-lysine modification protein desumoylation regulation of primary metabolic process protein modification by small protein removal peptidyl-amino acid modification protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process regulation of biological process regulation of post-translational protein modification regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation or removal regulation of protein desumoylation RNA transport nucleic acid transport mRNA transport establishment of RNA localization RNA localization nucleobase-containing compound transport protein localization to chromosome, centromeric region protein localization to kinetochore protein localization to chromosome protein localization to condensed chromosome cell division mitotic nuclear division regulation of cellular component organization regulation of cell cycle process organelle fission regulation of mitotic nuclear division regulation of organelle organization mitotic cell cycle regulation of mitotic cell cycle nuclear division mitotic cell cycle process regulation of nuclear division cell cycle regulation of cell cycle cell cycle process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription cellular response to biotic stimulus cellular response to stimulus cellular response to endogenous stimulus response to stimulus response to endogenous stimulus response to cell cycle checkpoint signaling response to spindle checkpoint signaling response to biotic stimulus	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel nuclear pore nuclear basket
B, BS, BZ, CG, CN B, BS, BZ, CG, CN, CU, DB, DI, DP, DW, ED, EK, ER, EY, FF, I	Nup85	structural molecule activity structural constituent of nuclear pore	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport establishment of localization establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus ribosomal large subunit export from nucleus cellular component biogenesis ribosome biogenesis organelle localization nuclear export ribosome localization protein localization establishment of protein localization nitrogen compound transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport mRNA transport mRNA export from nucleus RNA localization nucleobase-containing compound transport RNA transport nucleic acid transport gene expression macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process metabolic process macromolecule metabolic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane
AV, BA, OC, OH, OM AV, BA, OC, OH, OM, OR, OW, PB, PG, PL, PQ, PV, QA, QF, QK, QP	Nup59	binding phospholipid binding lipid binding structural molecule activity structural constituent of nuclear pore DNA binding single-stranded DNA binding nucleic acid binding	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis protein localization establishment of protein localization cellular localization NLS-bearing protein import into nucleus nitrogen compound transport nucleocytoplasmic transport transport cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis protein localization establishment of protein localization cellular localization NLS-bearing protein import into nucleus nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport cell division cellular response to stimulus response to stimulus response to heat mRNA transport response to temperature stimulus cellular response to stress mRNA export from nucleus response to stress RNA localization nuclear export nucleobase-containing compound transport cellular response to heat RNA transport nucleic acid transport response to nitrogen compound gene expression macromolecule biosynthetic process RNA export from nucleus mRNA export from nucleus in response to heat stress establishment of RNA localization biosynthetic process response to chemical metabolic process response to abiotic stimulus macromolecule metabolic process	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel nuclear pore nuclear basket
AW, BB, OD, OI, ON AW, BB, OD, OI, ON, OS, OX, PC, PH, PM, PR, PW, QB, QG, QL, QQ	Ndc1	spindle pole body anchor activity spindle pole body-nuclear membrane anchor activity protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity cytoskeletal anchor activity structural molecule activity structural constituent of nuclear pore	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization cellular localization spindle pole body localization microtubule organizing center localization RNA transport nitrogen compound transport transport cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization cellular localization spindle pole body localization microtubule organizing center localization RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport protein localization establishment of protein localization protein transport cellular macromolecule localization nucleocytoplasmic transport nuclear transport establishment of localization in cell intracellular transport spindle pole body duplication microtubule organizing center organization microtubule cytoskeleton organization cellular component biogenesis cellular component assembly spindle pole body organization microtubule-based process cell cycle cytoskeleton organization cell cycle process	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle nuclear pore transmembrane ring endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle nuclear pore transmembrane ring endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane microtubule organizing center cytoskeleton membraneless organelle spindle pole body intracellular membraneless organelle microtubule cytoskeleton cytoplasm
AX, BC, OE, OJ, OO AX, BC, OE, OJ, OO, OT, OY, PD, PI, PN, PS, PX, QC, QH, QM, QR	Pom34	structural molecule activity structural constituent of nuclear pore	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport establishment of localization spindle pole body duplication microtubule organizing center organization microtubule cytoskeleton organization cellular component biogenesis cellular component assembly spindle pole body organization microtubule-based process cell cycle cytoskeleton organization cell cycle process protein localization establishment of protein localization nitrogen compound transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport RNA transport nucleic acid transport mRNA transport establishment of RNA localization RNA localization nucleobase-containing compound transport	membrane-bounded organelle nuclear outer membrane intracellular anatomical structure nuclear membrane membrane nucleus organelle outer membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure bounding membrane of organelle organelle membrane-bounded organelle nuclear outer membrane intracellular anatomical structure nuclear membrane membrane nucleus organelle outer membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure bounding membrane of organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network nuclear envelope outer membrane organelle membrane membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen protein-containing complex nuclear protein-containing complex nuclear pore transmembrane ring nuclear pore
AY, BD, OF, OK, OP AY, BD, OF, OK, OP, OU, OZ, PE, PJ, PO, PT, PY, QD, QI, QN, QS	Pom152	protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity structural molecule activity structural constituent of nuclear pore	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cellular localization nucleocytoplasmic transport nuclear transport establishment of localization in cell intracellular transport spindle pole body duplication microtubule organizing center organization microtubule cytoskeleton organization cellular component biogenesis cellular component assembly spindle pole body organization microtubule-based process cell cycle cytoskeleton organization cell cycle process protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle nucleus membrane-enclosed lumen endomembrane system intracellular organelle lumen organelle envelope lumen organelle envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle nucleus membrane-enclosed lumen endomembrane system intracellular organelle lumen organelle envelope lumen organelle envelope organelle lumen nuclear envelope lumen nuclear envelope protein-containing complex nuclear protein-containing complex nuclear pore transmembrane ring nuclear pore nuclear membrane membrane organelle membrane cell periphery nuclear periphery nuclear lumen
BE, BF, QT, QU, QZ BE, BF, QT, QU, QZ, RA, RF, RG, RL, RM, RR, RS, RX, RY, SD, SE	Nup100	molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity RNA binding binding nucleic acid binding nuclear localization sequence binding signal sequence binding peptide binding structural molecule activity structural constituent of nuclear pore	localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell RNA localization localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process protein localization protein localization to nucleus localization within membrane protein localization to membrane protein localization to nuclear envelope protein localization to organelle cellular macromolecule localization protein localization to nuclear inner membrane establishment of protein localization import into nucleus establishment of protein localization to organelle protein transport protein import into nucleus intracellular protein transport cellular response to stimulus response to stimulus response to heat response to temperature stimulus cellular response to stress response to stress cellular response to heat response to nitrogen compound mRNA export from nucleus in response to heat stress response to chemical response to abiotic stimulus regulation of localization regulation of cellular process tRNA export from nucleus ribonucleoprotein complex localization regulation of intracellular transport regulation of ribonucleoprotein complex localization regulation of biological process regulation of tRNA export from nucleus regulation of transport regulation of RNA export from nucleus regulation of nucleobase-containing compound transport biological regulation regulation of nucleocytoplasmic transport tRNA transport regulation of cellular localization NLS-bearing protein import into nucleus positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process cellular component organization organelle organization chromosome organization cellular component organization or biogenesis transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery cellular component biogenesis cellular component assembly organelle assembly membraneless organelle assembly	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel nuclear pore cytoplasmic filaments
BG, BH, QV, QW, RB BG, BH, QV, QW, RB, RC, RH, RI, RN, RO, RT, RU, RZ, SA, SF, SG	Nup116	RNA binding binding nucleic acid binding structural molecule activity structural constituent of nuclear pore ATPase binding protein binding enzyme binding identical protein binding nuclear localization sequence binding signal sequence binding peptide binding	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular localization nitrogen compound transport cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization metabolic process macromolecule metabolic process tRNA export from nucleus tRNA transport chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus ribosomal large subunit export from nucleus protein-containing complex localization cellular component biogenesis ribosome biogenesis ribosome localization protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel nuclear pore cytoplasmic filaments
BJ, QY, RE, RK, RQ BJ, QY, RE, RK, RQ, RW, SC, SI	Gle1	enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity catalytic activity protein binding binding translation initiation factor binding ion binding inositol hexakisphosphate binding alcohol binding anion binding small molecule binding phospholipid binding enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity catalytic activity protein binding binding translation initiation factor binding ion binding inositol hexakisphosphate binding alcohol binding anion binding small molecule binding phospholipid binding lipid binding	cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process tRNA export from nucleus tRNA transport regulation of cellular process regulation of primary metabolic process post-transcriptional regulation of gene expression translational initiation protein metabolic process regulation of biosynthetic process regulation of biological process regulation of translational initiation regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process translation regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process regulation of metabolic process protein localization establishment of protein localization protein transport cellular macromolecule localization regulation of cellular component organization protein-containing complex disassembly regulation of protein-containing complex disassembly cellular component organization translational termination cellular component organization or biogenesis cellular component disassembly protein-containing complex organization regulation of translational termination RNA metabolic process nucleobase-containing compound biosynthetic process mRNA processing mRNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA processing	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle envelope nuclear envelope nucleus endomembrane system nuclear membrane membrane membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle envelope nuclear envelope nucleus endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore cytoplasmic filaments
BK, BL, SJ, SK, SO BK, BL, SJ, SK, SO, SP, ST, SU, SY, SZ, TD, TE, TI, TJ, TN, TO	Nup145	hydrolase activity catalytic activity RNA binding binding nucleic acid binding nuclear localization sequence binding signal sequence binding peptide binding structural molecule activity structural constituent of nuclear pore	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization RNA transport nitrogen compound transport nucleocytoplasmic transport transport nuclear transport nucleic acid transport intracellular transport tRNA export from nucleus establishment of localization RNA export from nucleus tRNA transport establishment of RNA localization establishment of localization in cell macromolecule localization RNA localization nuclear export nucleobase-containing compound transport protein localization protein localization to nucleus protein localization to membrane protein localization to nuclear envelope protein localization to organelle cellular macromolecule localization protein localization to nuclear inner membrane regulation of localization regulation of biological process regulation of cellular process regulation of transport biological regulation regulation of nucleocytoplasmic transport regulation of cellular localization regulation of intracellular transport establishment of protein localization import into nucleus establishment of protein localization to organelle protein transport protein import into nucleus intracellular protein transport mRNA transport mRNA export from nucleus poly(A)+ mRNA export from nucleus gene expression macromolecule biosynthetic process biosynthetic process metabolic process macromolecule metabolic process NLS-bearing protein import into nucleus subtelomeric heterochromatin formation negative regulation of biological process chromatin organization negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process regulation of macromolecule metabolic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription cellular response to stimulus double-strand break repair response to stimulus DNA metabolic process cellular response to stress DNA damage response response to stress DNA repair chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane nuclear pore central transport channel membraneless organelle intracellular membraneless organelle chromosome chromosome, telomeric region chromosomal region nuclear pore cytoplasmic filaments
BM, SN, SS, SX, TC BM, SN, SS, SX, TC, TH, TM, TR	Nup1	structural molecule activity structural constituent of nuclear pore nuclear localization sequence binding signal sequence binding binding peptide binding	cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process protein localization establishment of protein localization NLS-bearing protein import into nucleus protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport cellular component organization organelle organization chromosome organization cellular component organization or biogenesis transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus ribosomal large subunit export from nucleus protein-containing complex localization cellular component biogenesis ribosome biogenesis organelle localization ribosome localization	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel nuclear pore nuclear basket
BT, C, CA, CH, CO BT, C, CA, CH, CO, CV, DC, DJ, DQ, DX, EE, EL, ES, EZ, FG, J	Nup120	structural molecule activity structural constituent of nuclear pore identical protein binding protein binding binding	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization protein localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein export from nucleus establishment of localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization nuclear export intracellular protein transport subtelomeric heterochromatin formation regulation of cellular process negative regulation of biological process chromatin organization negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process mRNA transport mRNA export from nucleus RNA localization nucleobase-containing compound transport RNA transport nucleic acid transport RNA export from nucleus establishment of RNA localization positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription cellular response to stimulus double-strand break repair response to stimulus DNA metabolic process cellular response to stress DNA damage response response to stress DNA repair chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of RNA metabolic process establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus ribosomal large subunit export from nucleus cellular component biogenesis ribosome biogenesis ribosome localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein localization to organelle protein import into nucleus positive regulation of transcription by RNA polymerase II response to heat response to temperature stimulus cellular response to heat response to nitrogen compound mRNA export from nucleus in response to heat stress response to chemical response to abiotic stimulus	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane membraneless organelle intracellular membraneless organelle chromosome chromosome, telomeric region chromosomal region
BN, BO, SL, SM, SQ BN, BO, SL, SM, SQ, SR, SV, SW, TA, TB, TF, TG, TK, TL, TP, TQ	Nup60	binding phospholipid binding lipid binding structural molecule activity structural constituent of nuclear pore	localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell RNA localization localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process protein localization establishment of protein localization NLS-bearing protein import into nucleus protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport intracellular mRNA localization regulation of cellular process regulation of protein modification process peptidyl-lysine modification protein desumoylation regulation of primary metabolic process protein modification by small protein removal peptidyl-amino acid modification protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process regulation of biological process regulation of post-translational protein modification regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process macromolecule modification post-translational protein modification regulation of metabolic process protein modification by small protein conjugation or removal regulation of protein desumoylation protein export from nucleus cellular component organization organelle organization chromosome organization cellular component organization or biogenesis transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery negative regulation of biological process chromatin organization negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process cellular response to stimulus double-strand break repair response to stimulus DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress DNA repair post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery response to heat response to temperature stimulus cellular response to heat response to nitrogen compound mRNA export from nucleus in response to heat stress response to chemical response to abiotic stimulus	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel cytoplasm cytosol nuclear pore nuclear basket
BP, TS, TU, TW, TY BP, TS, TU, TW, TY, UA, UC, UE	Mlp1	RNA binding binding nucleic acid binding mRNA binding DNA binding chromatin binding double-stranded DNA binding DNA-DNA tethering activity promoter-terminator loop anchoring activity chromatin DNA binding chromatin loop anchoring activity molecular adaptor activity ribonucleoprotein complex binding protein-containing complex binding RNA binding binding nucleic acid binding mRNA binding DNA binding chromatin binding double-stranded DNA binding DNA-DNA tethering activity promoter-terminator loop anchoring activity chromatin DNA binding chromatin loop anchoring activity molecular adaptor activity ribonucleoprotein complex binding protein-containing complex binding structural molecule activity structural constituent of nuclear pore	localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell RNA localization localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process cellular response to stimulus response to stimulus response to endogenous stimulus response to mitotic cell cycle checkpoint signaling negative regulation of protein import into nucleus during spindle assembly checkpoint response to biotic stimulus cellular response to biotic stimulus cellular response to endogenous stimulus response to mitotic cell cycle spindle assembly checkpoint signaling response to spindle assembly checkpoint signaling response to mitotic spindle checkpoint signaling response to cell cycle checkpoint signaling response to spindle checkpoint signaling primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress DNA repair protein localization protein localization to nuclear pore protein localization to organelle cellular macromolecule localization protein localization to nucleus protein localization to nuclear envelope regulation of cellular process catabolic process negative regulation of biological process RNA metabolic process macromolecule catabolic process negative regulation of cellular process RNA surveillance RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process nuclear RNA surveillance nuclear-transcribed mRNA catabolic process regulation of biological process negative regulation of metabolic process nuclear mRNA surveillance biological regulation regulation of macromolecule metabolic process mRNA metabolic process nucleobase-containing compound catabolic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process regulation of metabolic process establishment of protein localization import into nucleus establishment of protein localization to organelle protein transport protein import into nucleus intracellular protein transport	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system protein-containing complex nuclear protein-containing complex nuclear pore membrane-enclosed lumen membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system protein-containing complex nuclear protein-containing complex nuclear pore membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen nuclear pore nuclear basket
BQ, TT, TV, TX, TZ BQ, TT, TV, TX, TZ, UB, UD, UF	Mlp2	ribonucleoprotein complex binding protein-containing complex binding binding structural molecule activity structural constituent of nuclear pore	localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell RNA localization localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process regulation of cellular process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process cellular response to stimulus response to stimulus response to endogenous stimulus response to mitotic cell cycle checkpoint signaling negative regulation of protein import into nucleus during spindle assembly checkpoint response to biotic stimulus cellular response to biotic stimulus cellular response to endogenous stimulus response to mitotic cell cycle spindle assembly checkpoint signaling response to spindle assembly checkpoint signaling response to mitotic spindle checkpoint signaling response to cell cycle checkpoint signaling response to spindle checkpoint signaling cellular component organization organelle organization chromosome organization cellular component organization or biogenesis transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery microtubule organizing center organization microtubule cytoskeleton organization spindle pole body organization microtubule-based process cell cycle cytoskeleton organization cell cycle process post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle envelope nuclear envelope nucleus endomembrane system microtubule organizing center cytoskeleton membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle envelope nuclear envelope nucleus endomembrane system microtubule organizing center cytoskeleton membraneless organelle spindle pole body intracellular membraneless organelle microtubule cytoskeleton protein-containing complex nuclear protein-containing complex nuclear pore membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen nuclear pore nuclear basket
BU, CB, CI, CP, CW BU, CB, CI, CP, CW, D, DD, DK, DR, DY, EF, EM, ET, FA, FH, K	Nup133	structural molecule activity structural constituent of nuclear pore	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization RNA transport nitrogen compound transport nucleocytoplasmic transport transport nuclear transport nucleic acid transport intracellular transport tRNA export from nucleus establishment of localization RNA export from nucleus tRNA transport establishment of RNA localization establishment of localization in cell macromolecule localization RNA localization nuclear export nucleobase-containing compound transport chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery cellular response to stimulus cellular response to heat response to stimulus cellular response to stress response to stress response to heat response to abiotic stimulus response to temperature stimulus regulation of cellular process negative regulation of biological process chromatin organization negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport mRNA transport mRNA export from nucleus response to nitrogen compound mRNA export from nucleus in response to heat stress response to chemical poly(A)+ mRNA export from nucleus subtelomeric heterochromatin formation positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription double-strand break repair DNA metabolic process DNA damage response DNA repair post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of RNA metabolic process positive regulation of transcription by RNA polymerase II	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane cytoplasm cytosol membraneless organelle intracellular membraneless organelle chromosome chromosome, telomeric region chromosomal region
BV, CC, CJ, CQ, CX BV, CC, CJ, CQ, CX, DE, DL, DS, DZ, E, EG, EN, EU, FB, FI, L	Nup145c	hydrolase activity catalytic activity RNA binding binding nucleic acid binding nuclear localization sequence binding signal sequence binding peptide binding structural molecule activity structural constituent of nuclear pore	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization RNA transport nitrogen compound transport nucleocytoplasmic transport transport nuclear transport nucleic acid transport intracellular transport tRNA export from nucleus establishment of localization RNA export from nucleus tRNA transport establishment of RNA localization establishment of localization in cell macromolecule localization RNA localization nuclear export nucleobase-containing compound transport protein localization protein localization to nucleus protein localization to membrane protein localization to nuclear envelope protein localization to organelle cellular macromolecule localization protein localization to nuclear inner membrane regulation of localization regulation of biological process regulation of cellular process regulation of transport biological regulation regulation of nucleocytoplasmic transport regulation of cellular localization regulation of intracellular transport establishment of protein localization import into nucleus establishment of protein localization to organelle protein transport protein import into nucleus intracellular protein transport mRNA transport mRNA export from nucleus poly(A)+ mRNA export from nucleus gene expression macromolecule biosynthetic process biosynthetic process metabolic process macromolecule metabolic process NLS-bearing protein import into nucleus subtelomeric heterochromatin formation negative regulation of biological process chromatin organization negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process regulation of macromolecule metabolic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription cellular response to stimulus double-strand break repair response to stimulus DNA metabolic process cellular response to stress DNA damage response response to stress DNA repair chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane nuclear pore central transport channel membraneless organelle intracellular membraneless organelle chromosome chromosome, telomeric region chromosomal region nuclear pore cytoplasmic filaments
BW, CD, CK, CR, CY BW, CD, CK, CR, CY, DF, DM, DT, EA, EH, EO, EV, F, FC, FJ, M	Seh1	structural molecule activity structural constituent of nuclear pore	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction regulation of TORC1 signaling positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication cellular process TORC1 signaling positive regulation of signaling RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport protein localization establishment of protein localization cellular localization protein transport cellular macromolecule localization nucleocytoplasmic transport nuclear transport establishment of localization in cell intracellular transport response to nutrient levels cellular response to amino acid starvation cellular response to starvation cellular response to nutrient levels cellular response to stress response to stress response to amino acid starvation response to starvation	protein-containing complex Seh1-associated complex membrane-bounded organelle intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope protein-containing complex Seh1-associated complex membrane-bounded organelle intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane vacuolar membrane vacuole bounding membrane of organelle cytoplasm
BX, CE, CL, CS, CZ BX, CE, CL, CS, CZ, DG, DN, DU, EB, EI, EP, EW, FD, FK, G, N	Sec13	structural molecule activity	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization regulation of localization regulation of cellular process transport positive regulation of biological process cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization regulation of localization regulation of cellular process transport positive regulation of biological process positive regulation of ER to Golgi vesicle-mediated transport vesicle-mediated transport establishment of localization in cell positive regulation of intracellular transport positive regulation of cellular process regulation of intracellular transport regulation of biological process regulation of ER to Golgi vesicle-mediated transport regulation of transport biological regulation intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport regulation of vesicle-mediated transport establishment of localization positive regulation of transport regulation of cellular localization Golgi vesicle transport protein localization protein exit from endoplasmic reticulum establishment of protein localization nitrogen compound transport protein transport cellular macromolecule localization macromolecule localization intracellular protein transport membrane organization vesicle budding from membrane vesicle organization COPII-coated vesicle budding RNA transport nucleic acid transport mRNA transport establishment of RNA localization RNA localization nucleobase-containing compound transport cellular response to stimulus catabolic process response to stimulus proteolysis involved in protein catabolic process response to nitrogen compound proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process ERAD pathway cellular response to stress response to chemical response to stress proteolysis metabolic process protein metabolic process macromolecule metabolic process response to endoplasmic reticulum stress positive regulation of cell communication positive regulation of signal transduction signaling regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction TOR signaling regulation of signaling regulation of TOR signaling positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling nucleocytoplasmic transport nuclear transport regulation of TORC1 signaling TORC1 signaling protein localization to nucleus import into nucleus establishment of protein localization to organelle protein localization to organelle protein import into nucleus regulation of protein exit from endoplasmic reticulum regulation of protein localization positive regulation of establishment of protein localization positive regulation of protein transport regulation of establishment of protein localization regulation of protein transport positive regulation of protein exit from endoplasmic reticulum positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport positive regulation of TORC1 signaling positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore cell periphery vesicle coat intracellular vesicle transport vesicle membrane membrane protein complex membrane coat bounding membrane of organelle vesicle membrane cytoplasmic vesicle ER to Golgi transport vesicle membrane coated vesicle vesicle transport vesicle membrane coated membrane COPII vesicle coat cytoplasmic vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle cytoplasm organelle membrane organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane Seh1-associated complex vacuolar membrane vacuole
FL, FM, FT, FU, GB FL, FM, FT, FU, GB, GC, GJ, GK, GR, GS, GZ, HA, HH, HI, O, P	Dyn2	protein binding binding dynein intermediate chain binding	establishment of organelle localization cellular localization microtubule cytoskeleton organization spindle localization establishment or maintenance of cell polarity mitotic cell cycle cellular component organization localization establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell cell cycle establishment of organelle localization cellular localization microtubule cytoskeleton organization spindle localization establishment or maintenance of cell polarity mitotic cell cycle cellular component organization localization establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell cell cycle cellular component organization or biogenesis microtubule cytoskeleton organization involved in mitosis cell cycle process establishment of localization establishment of cell polarity organelle organization mitotic cell cycle process establishment of mitotic spindle orientation cellular process microtubule-based process cytoskeleton organization RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport organelle transport along microtubule nucleus localization intracellular transport nuclear migration along microtubule microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement nuclear migration protein localization establishment of protein localization protein transport cellular macromolecule localization nucleocytoplasmic transport nuclear transport nuclear pore organization protein-containing complex organization pore complex assembly cellular component biogenesis nuclear pore complex assembly nucleus organization cellular component assembly protein-containing complex assembly	peroxisomal importomer complex protein-containing complex transporter complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system membrane-enclosed lumen peroxisomal importomer complex protein-containing complex transporter complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen polymeric cytoskeletal fiber intracellular membraneless organelle cytoplasmic microtubule cytoskeleton membraneless organelle cytoplasm supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton nuclear protein-containing complex nuclear pore cytoplasmic dynein complex catalytic complex dynein complex microtubule associated complex
FN, FO, FV, FW, GD FN, FO, FV, FW, GD, GE, GL, GM, GT, GU, HB, HC, HJ, HK, Q, R	Nup82	structural molecule activity structural constituent of nuclear pore	establishment of organelle localization cellular localization ribonucleoprotein complex biogenesis nucleocytoplasmic transport transport nuclear transport ribosomal subunit export from nucleus intracellular transport establishment of localization protein-containing complex localization cellular component biogenesis localization ribosome biogenesis ribosomal small subunit export from nucleus organelle localization establishment of organelle localization cellular localization ribonucleoprotein complex biogenesis nucleocytoplasmic transport transport nuclear transport ribosomal subunit export from nucleus intracellular transport establishment of localization protein-containing complex localization cellular component biogenesis localization ribosome biogenesis ribosomal small subunit export from nucleus organelle localization establishment of localization in cell cellular process cellular component organization or biogenesis nuclear export ribosome localization protein localization establishment of protein localization nitrogen compound transport protein export from nucleus protein transport cellular macromolecule localization macromolecule localization intracellular protein transport mRNA transport mRNA export from nucleus RNA localization nucleobase-containing compound transport RNA transport nucleic acid transport gene expression macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process metabolic process macromolecule metabolic process ribosomal large subunit export from nucleus protein localization to nucleus import into nucleus establishment of protein localization to organelle protein localization to organelle protein import into nucleus	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear pore linkers nuclear protein-containing complex nuclear pore cytoplasm cytosol nuclear pore cytoplasmic filaments

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, BR, BY, CF, CM A, BR, BY, CF, CM, CT, DA, DH, DO, DV, EC, EJ, EQ, EX, FE, H	IPR007252	Nuclear pore protein 84/107	Family
FP, FQ, FX, FY, GF FP, FQ, FX, FY, GF, GG, GN, GO, GV, GW, HD, HE, HL, HM, S, T	IPR039462	Nucleoporin Nup159/Nup146, N-terminal	Domain
FP, FQ, FX, FY, GF FP, FQ, FX, FY, GF, GG, GN, GO, GV, GW, HD, HE, HL, HM, S, T	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
AB, AF, AJ, FR, FS AB, AF, AJ, FR, FS, FZ, GA, GH, GI, GP, GQ, GX, GY, HF, HG, HN, HO, HR, HS, HZ, IA, IH, II, IP, IQ, IX, IY, JF, JG, JN, JO, JV, JW, KD, KE, KL, KM, KT, KU, LB, LC, LJ, LK, LR, LS, U, V, X	IPR007758	Nucleoporin, NSP1-like, C-terminal	Domain
AB, AF, AJ, FR, FS AB, AF, AJ, FR, FS, FZ, GA, GH, GI, GP, GQ, GX, GY, HF, HG, HN, HO, HR, HS, HZ, IA, IH, II, IP, IQ, IX, IY, JF, JG, JN, JO, JV, JW, KD, KE, KL, KM, KT, KU, LB, LC, LJ, LK, LR, LS, U, V, X	IPR026010	Nucleoporin NSP1/NUP62	Family
AA, AE, AI, HP, HQ AA, AE, AI, HP, HQ, HX, HY, IF, IG, IN, IO, IV, IW, JD, JE, JL, JM, JT, JU, KB, KC, KJ, KK, KR, KS, KZ, LA, LH, LI, LP, LQ, W	IPR007231	Nucleoporin interacting component Nup93/Nic96	Family
AC, AG, AK, HT, HU AC, AG, AK, HT, HU, IB, IC, IJ, IK, IR, IS, IZ, JA, JH, JI, JP, JQ, JX, JY, KF, KG, KN, KO, KV, KW, LD, LE, LL, LM, LT, LU, Y	IPR024882	Nucleoporin p58/p45/NUP49	Family
AC, AG, AK, HT, HU AC, AG, AK, HT, HU, IB, IC, IJ, IK, IR, IS, IZ, JA, JH, JI, JP, JQ, JX, JY, KF, KG, KN, KO, KV, KW, LD, LE, LL, LM, LT, LU, Y	IPR025574	Nucleoporin FG repeat	Repeat
AD, AH, AL, HV, HW AD, AH, AL, HV, HW, ID, IE, IL, IM, IT, IU, JB, JC, JJ, JK, JR, JS, JZ, KA, KH, KI, KP, KQ, KX, KY, LF, LG, LN, LO, LV, LW, Z	IPR025574	Nucleoporin FG repeat	Repeat
AD, AH, AL, HV, HW AD, AH, AL, HV, HW, ID, IE, IL, IM, IT, IU, JB, JC, JJ, JK, JR, JS, JZ, KA, KH, KI, KP, KQ, KX, KY, LF, LG, LN, LO, LV, LW, Z	IPR024864	Nucleoporin Nup54/Nup57/Nup44	Family
AD, AH, AL, HV, HW AD, AH, AL, HV, HW, ID, IE, IL, IM, IT, IU, JB, JC, JJ, JK, JR, JS, JZ, KA, KH, KI, KP, KQ, KX, KY, LF, LG, LN, LO, LV, LW, Z	IPR025712	Nucleoporin Nup54, alpha-helical domain	Domain
AM, AQ, LX, MB, MF AM, AQ, LX, MB, MF, MJ, MN, MR, MV, MZ, ND, NH, NL, NP, NT, NX	IPR042537	Nucleoporin, Nup155-like, C-terminal, subdomain 2	Homologous Superfamily
AM, AQ, LX, MB, MF AM, AQ, LX, MB, MF, MJ, MN, MR, MV, MZ, ND, NH, NL, NP, NT, NX	IPR042533	Nucleoporin, Nup155-like, C-terminal, subdomain 1	Homologous Superfamily
AM, AQ, LX, MB, MF AM, AQ, LX, MB, MF, MJ, MN, MR, MV, MZ, ND, NH, NL, NP, NT, NX	IPR014908	Nucleoporin, Nup133/Nup155-like, N-terminal	Domain
AM, AQ, LX, MB, MF AM, AQ, LX, MB, MF, MJ, MN, MR, MV, MZ, ND, NH, NL, NP, NT, NX	IPR004870	Nucleoporin, Nup155-like	Family
AM, AQ, LX, MB, MF AM, AQ, LX, MB, MF, MJ, MN, MR, MV, MZ, ND, NH, NL, NP, NT, NX	IPR007187	Nucleoporin, Nup133/Nup155-like, C-terminal	Domain
AN, AR, LY, MC, MG AN, AR, LY, MC, MG, MK, MO, MS, MW, NA, NE, NI, NM, NQ, NU, NY	IPR042537	Nucleoporin, Nup155-like, C-terminal, subdomain 2	Homologous Superfamily
AN, AR, LY, MC, MG AN, AR, LY, MC, MG, MK, MO, MS, MW, NA, NE, NI, NM, NQ, NU, NY	IPR042533	Nucleoporin, Nup155-like, C-terminal, subdomain 1	Homologous Superfamily
AN, AR, LY, MC, MG AN, AR, LY, MC, MG, MK, MO, MS, MW, NA, NE, NI, NM, NQ, NU, NY	IPR014908	Nucleoporin, Nup133/Nup155-like, N-terminal	Domain
AN, AR, LY, MC, MG AN, AR, LY, MC, MG, MK, MO, MS, MW, NA, NE, NI, NM, NQ, NU, NY	IPR004870	Nucleoporin, Nup155-like	Family
AN, AR, LY, MC, MG AN, AR, LY, MC, MG, MK, MO, MS, MW, NA, NE, NI, NM, NQ, NU, NY	IPR007187	Nucleoporin, Nup133/Nup155-like, C-terminal	Domain
AO, AS, LZ, MD, MH AO, AS, LZ, MD, MH, ML, MP, MT, MX, NB, NF, NJ, NN, NR, NV, NZ	IPR044840	Nucleoporin Nup188	Family
AO, AS, LZ, MD, MH AO, AS, LZ, MD, MH, ML, MP, MT, MX, NB, NF, NJ, NN, NR, NV, NZ	IPR041634	Nuclear pore protein Nup188, C-terminal	Domain
AO, AS, LZ, MD, MH AO, AS, LZ, MD, MH, ML, MP, MT, MX, NB, NF, NJ, NN, NR, NV, NZ	IPR048883	Nucleoporin Nup188, N-terminal subdomain III	Domain
AO, AS, LZ, MD, MH AO, AS, LZ, MD, MH, ML, MP, MT, MX, NB, NF, NJ, NN, NR, NV, NZ	IPR018864	Nucleoporin Nup188, N-terminal	Domain
AP, AT, MA, ME, MI AP, AT, MA, ME, MI, MM, MQ, MU, MY, NC, NG, NK, NO, NS, NW, OA	IPR021827	Nucleoporin Nup186/Nup192/Nup205	Family
AU, AZ, OB, OG, OL AU, AZ, OB, OG, OL, OQ, OV, PA, PF, PK, PP, PU, PZ, QE, QJ, QO	IPR007846	RNA-recognition motif (RRM) Nup35-type domain	Domain
AU, AZ, OB, OG, OL AU, AZ, OB, OG, OL, OQ, OV, PA, PF, PK, PP, PU, PZ, QE, QJ, QO	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
AU, AZ, OB, OG, OL AU, AZ, OB, OG, OL, OQ, OV, PA, PF, PK, PP, PU, PZ, QE, QJ, QO	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
B, BS, BZ, CG, CN B, BS, BZ, CG, CN, CU, DB, DI, DP, DW, ED, EK, ER, EY, FF, I	IPR011502	Nucleoporin Nup85-like	Family
AV, BA, OC, OH, OM AV, BA, OC, OH, OM, OR, OW, PB, PG, PL, PQ, PV, QA, QF, QK, QP	IPR007846	RNA-recognition motif (RRM) Nup35-type domain	Domain
AV, BA, OC, OH, OM AV, BA, OC, OH, OM, OR, OW, PB, PG, PL, PQ, PV, QA, QF, QK, QP	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
AV, BA, OC, OH, OM AV, BA, OC, OH, OM, OR, OW, PB, PG, PL, PQ, PV, QA, QF, QK, QP	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
AW, BB, OD, OI, ON AW, BB, OD, OI, ON, OS, OX, PC, PH, PM, PR, PW, QB, QG, QL, QQ	IPR019049	Nucleoporin protein Ndc1-Nup	Family
AX, BC, OE, OJ, OO AX, BC, OE, OJ, OO, OT, OY, PD, PI, PN, PS, PX, QC, QH, QM, QR	IPR012578	Nuclear pore complex component	Family
AY, BD, OF, OK, OP AY, BD, OF, OK, OP, OU, OZ, PE, PJ, PO, PT, PY, QD, QI, QN, QS	IPR056544	Nucleoporin POM152, immunoglobulin-like domain	Domain
AY, BD, OF, OK, OP AY, BD, OF, OK, OP, OU, OZ, PE, PJ, PO, PT, PY, QD, QI, QN, QS	IPR056540	Nucleoporin POM152, N-terminal transmembrane domain	Domain
AY, BD, OF, OK, OP AY, BD, OF, OK, OP, OU, OZ, PE, PJ, PO, PT, PY, QD, QI, QN, QS	IPR056542	Nucleoporin POM152, first Ig-like domain	Domain
AY, BD, OF, OK, OP AY, BD, OF, OK, OP, OU, OZ, PE, PJ, PO, PT, PY, QD, QI, QN, QS	IPR056543	Nucleoporin POM152, ninth Ig-like domain	Domain
AY, BD, OF, OK, OP AY, BD, OF, OK, OP, OU, OZ, PE, PJ, PO, PT, PY, QD, QI, QN, QS	IPR037701	Nucleoporin Pom152	Family
AY, BD, OF, OK, OP AY, BD, OF, OK, OP, OU, OZ, PE, PJ, PO, PT, PY, QD, QI, QN, QS	IPR056541	Nucleoporin POM152, Ig-like domain	Domain
BE, BF, QT, QU, QZ BE, BF, QT, QU, QZ, RA, RF, RG, RL, RM, RR, RS, RX, RY, SD, SE	IPR025574	Nucleoporin FG repeat	Repeat
BE, BF, QT, QU, QZ BE, BF, QT, QU, QZ, RA, RF, RG, RL, RM, RR, RS, RX, RY, SD, SE	IPR037665	Nucleoporin peptidase S59-like	Family
BE, BF, QT, QU, QZ BE, BF, QT, QU, QZ, RA, RF, RG, RL, RM, RR, RS, RX, RY, SD, SE	IPR036903	Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain superfamily	Homologous Superfamily
BE, BF, QT, QU, QZ BE, BF, QT, QU, QZ, RA, RF, RG, RL, RM, RR, RS, RX, RY, SD, SE	IPR007230	Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain	Domain
BG, BH, QV, QW, RB BG, BH, QV, QW, RB, RC, RH, RI, RN, RO, RT, RU, RZ, SA, SF, SG	IPR025574	Nucleoporin FG repeat	Repeat
BG, BH, QV, QW, RB BG, BH, QV, QW, RB, RC, RH, RI, RN, RO, RT, RU, RZ, SA, SF, SG	IPR037665	Nucleoporin peptidase S59-like	Family
BG, BH, QV, QW, RB BG, BH, QV, QW, RB, RC, RH, RI, RN, RO, RT, RU, RZ, SA, SF, SG	IPR036903	Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain superfamily	Homologous Superfamily
BG, BH, QV, QW, RB BG, BH, QV, QW, RB, RC, RH, RI, RN, RO, RT, RU, RZ, SA, SF, SG	IPR007230	Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain	Domain
BJ, QY, RE, RK, RQ BJ, QY, RE, RK, RQ, RW, SC, SI	IPR012476	mRNA export factor GLE1-like	Family
BJ, QY, RE, RK, RQ BJ, QY, RE, RK, RQ, RW, SC, SI	IPR038506	GLE1-like superfamily	Homologous Superfamily
BK, BL, SJ, SK, SO BK, BL, SJ, SK, SO, SP, ST, SU, SY, SZ, TD, TE, TI, TJ, TN, TO	IPR025574	Nucleoporin FG repeat	Repeat
BK, BL, SJ, SK, SO BK, BL, SJ, SK, SO, SP, ST, SU, SY, SZ, TD, TE, TI, TJ, TN, TO	IPR037665	Nucleoporin peptidase S59-like	Family
BK, BL, SJ, SK, SO BK, BL, SJ, SK, SO, SP, ST, SU, SY, SZ, TD, TE, TI, TJ, TN, TO	IPR036903	Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain superfamily	Homologous Superfamily
BK, BL, SJ, SK, SO BK, BL, SJ, SK, SO, SP, ST, SU, SY, SZ, TD, TE, TI, TJ, TN, TO	IPR007230	Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain	Domain
BK, BL, SJ, SK, SO BK, BL, SJ, SK, SO, SP, ST, SU, SY, SZ, TD, TE, TI, TJ, TN, TO	IPR021967	Nuclear pore complex protein NUP96, C-terminal domain	Domain
BT, C, CA, CH, CO BT, C, CA, CH, CO, CV, DC, DJ, DQ, DX, EE, EL, ES, EZ, FG, J	IPR021717	Nucleoporin Nup120/160	Family
BT, C, CA, CH, CO BT, C, CA, CH, CO, CV, DC, DJ, DQ, DX, EE, EL, ES, EZ, FG, J	IPR055090	Nucleoporin NUP120, helical domain, saccharomycetes	Domain
BN, BO, SL, SM, SQ BN, BO, SL, SM, SQ, SR, SV, SW, TA, TB, TF, TG, TK, TL, TP, TQ	IPR034432	Nucleoporin nup60	Family
BP, TS, TU, TW, TY BP, TS, TU, TW, TY, UA, UC, UE	IPR001611	Leucine-rich repeat	Repeat
BP, TS, TU, TW, TY BP, TS, TU, TW, TY, UA, UC, UE	IPR012929	Nucleoprotein TPR/MLP1	Domain
BU, CB, CI, CP, CW BU, CB, CI, CP, CW, D, DD, DK, DR, DY, EF, EM, ET, FA, FH, K	IPR037624	Nuclear pore complex protein Nup133-like	Family
BU, CB, CI, CP, CW BU, CB, CI, CP, CW, D, DD, DK, DR, DY, EF, EM, ET, FA, FH, K	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
BU, CB, CI, CP, CW BU, CB, CI, CP, CW, D, DD, DK, DR, DY, EF, EM, ET, FA, FH, K	IPR014908	Nucleoporin, Nup133/Nup155-like, N-terminal	Domain
BV, CC, CJ, CQ, CX BV, CC, CJ, CQ, CX, DE, DL, DS, DZ, E, EG, EN, EU, FB, FI, L	IPR025574	Nucleoporin FG repeat	Repeat
BV, CC, CJ, CQ, CX BV, CC, CJ, CQ, CX, DE, DL, DS, DZ, E, EG, EN, EU, FB, FI, L	IPR037665	Nucleoporin peptidase S59-like	Family
BV, CC, CJ, CQ, CX BV, CC, CJ, CQ, CX, DE, DL, DS, DZ, E, EG, EN, EU, FB, FI, L	IPR036903	Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain superfamily	Homologous Superfamily
BV, CC, CJ, CQ, CX BV, CC, CJ, CQ, CX, DE, DL, DS, DZ, E, EG, EN, EU, FB, FI, L	IPR007230	Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain	Domain
BV, CC, CJ, CQ, CX BV, CC, CJ, CQ, CX, DE, DL, DS, DZ, E, EG, EN, EU, FB, FI, L	IPR021967	Nuclear pore complex protein NUP96, C-terminal domain	Domain
BW, CD, CK, CR, CY BW, CD, CK, CR, CY, DF, DM, DT, EA, EH, EO, EV, F, FC, FJ, M	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
BW, CD, CK, CR, CY BW, CD, CK, CR, CY, DF, DM, DT, EA, EH, EO, EV, F, FC, FJ, M	IPR037363	Sec13/Seh1 family	Family
BW, CD, CK, CR, CY BW, CD, CK, CR, CY, DF, DM, DT, EA, EH, EO, EV, F, FC, FJ, M	IPR001680	WD40 repeat	Repeat
BW, CD, CK, CR, CY BW, CD, CK, CR, CY, DF, DM, DT, EA, EH, EO, EV, F, FC, FJ, M	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
BX, CE, CL, CS, CZ BX, CE, CL, CS, CZ, DG, DN, DU, EB, EI, EP, EW, FD, FK, G, N	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
BX, CE, CL, CS, CZ BX, CE, CL, CS, CZ, DG, DN, DU, EB, EI, EP, EW, FD, FK, G, N	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
BX, CE, CL, CS, CZ BX, CE, CL, CS, CZ, DG, DN, DU, EB, EI, EP, EW, FD, FK, G, N	IPR037363	Sec13/Seh1 family	Family
BX, CE, CL, CS, CZ BX, CE, CL, CS, CZ, DG, DN, DU, EB, EI, EP, EW, FD, FK, G, N	IPR001680	WD40 repeat	Repeat
FL, FM, FT, FU, GB FL, FM, FT, FU, GB, GC, GJ, GK, GR, GS, GZ, HA, HH, HI, O, P	IPR037177	Dynein light chain superfamily	Homologous Superfamily
FL, FM, FT, FU, GB FL, FM, FT, FU, GB, GC, GJ, GK, GR, GS, GZ, HA, HH, HI, O, P	IPR001372	Dynein light chain, type 1/2	Family
FL, FM, FT, FU, GB FL, FM, FT, FU, GB, GC, GJ, GK, GR, GS, GZ, HA, HH, HI, O, P	IPR019763	Dynein light chain, type 1/2, conserved site	Conserved Site
FN, FO, FV, FW, GD FN, FO, FV, FW, GD, GE, GL, GM, GT, GU, HB, HC, HJ, HK, Q, R	IPR037700	Nucleoporin NUP88/NUP82	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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.id_divider{ color: #ccc; padding: 0 10px 0 10px; } .extended_id_info{ color: #ccc; font-size: 18px; position: relative; top: -10px; left: 4px; } 8ZZC | pdb_00008zzc

Integrative structure and functional anatomy of eight spokes of a nuclear pore complex

External Resource: Annotation

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage

8ZZC | pdb_00008zzc