Download MendeleyComparative analysis of hPARP9 macro domains
Fourkiotis, K.N., Chikunova, A., Tsika, C.A., Kravvariti, P.K., Tsatsouli, A.S., Perrakis, A., Spyroulias, A.G.To be published.
9QYF | pdb_00009qyf
PARP9 Macro Domain 2 in complex with ADPr
- PDB DOI: https://doi.org/10.2210/pdb9QYF/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2025-04-17 Released: 2025-05-28
- Funding Organization(s): European Union (EU), European Regional Development Fund
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.30 ?
- R-Value Free: 0.173 (Depositor), 0.174 (DCC)
- R-Value Work: 0.133 (Depositor), 0.134 (DCC)
- R-Value Observed: 0.135 (Depositor)
Starting Model: experimental
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This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Protein mono-ADP-ribosyltransferase PARP9 | 197 | Homo sapiens | Mutation(s): 0 Gene Names: PARP9, BAL, BAL1 EC: 2.4.2 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q8IXQ6 (Homo sapiens) Explore Q8IXQ6 Go to UniProtKB: Q8IXQ6 | |||||
PHAROS: Q8IXQ6 GTEx: ENSG00000138496 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q8IXQ6 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| AR6 (Subject of Investigation/LOI) Query on AR6 | C [auth A] | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE C15 H23 N5 O14 P2 SRNWOUGRCWSEMX-ZQSHOCFMSA-N |  | ||
| APR (Subject of Investigation/LOI) Query on APR | B [auth A] | ADENOSINE-5-DIPHOSPHORIBOSE C15 H23 N5 O14 P2 SRNWOUGRCWSEMX-KEOHHSTQSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.30 ?
- R-Value Free: 0.173 (Depositor), 0.174 (DCC)
- R-Value Work: 0.133 (Depositor), 0.134 (DCC)
- R-Value Observed: 0.135 (Depositor)
Space Group: P 43 21 2
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 52.143 | ¦Á = 90 |
| b = 52.143 | ¦Â = 90 |
| c = 132.158 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| XDS | data reduction |
| Aimless | data scaling |
| MOLREP | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-05-28 Deposition Author(s): Fourkiotis, K.N., Chikunova, A., Tsika, C.A., Kravvariti, P.K., Tsatsouli, A.S., Perrakis, A., Spyroulias, A.G.
| Funding Organization | Location | Grant Number |
|---|---|---|
| European Union (EU) | European Union | 101087215-ESPERANCE |
| European Union (EU) | European Union | 871037-iNEXT-Discovery |
| European Regional Development Fund | European Union | 5002550-INSPIRED |
| European Union (EU) | European Union | 101159708-MILESTONE |
Revision History (Full details and data files)
- Version 1.0: 2025-05-28
Type: Initial release
