Molecular architecture and inhibition mechanism of human ATR-ATRIP
Wang, G., Wang, P., Zheng, Z., Zhang, Q., Xu, C., Xu, X., Jian, L., Zhao, Z., Cai, G., Wang, X.(2025) Sci Bull (Beijing) 
Experimental Data Snapshot
wwPDB Validation   3D Report Full Report
Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Serine/threonine-protein kinase ATR | 2,644 | Homo sapiens | Mutation(s): 0  Gene Names: ATR, FRP1 EC: 2.7.11.1 | ![]() | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q13535 (Homo sapiens) Explore Q13535  Go to UniProtKB:  Q13535 | |||||
PHAROS:  Q13535 GTEx:  ENSG00000175054  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q13535 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 1 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
A1EIK (Subject of Investigation/LOI) Query on A1EIK | C [auth A], D [auth B] | RP-3500 C21 H26 N6 O3 YIHHYCIYAIVQKX-MBIULKOWSA-N |
Task | Software Package | Version |
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MODEL REFINEMENT | PHENIX | 1.16_3549 |
Funding Organization | Location | Grant Number |
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National Natural Science Foundation of China (NSFC) | China | -- |