Molecular architecture and inhibition mechanism of human ATR-ATRIP
Wang, G., Wang, P., Zheng, Z., Zhang, Q., Xu, C., Xu, X., Jian, L., Zhao, Z., Cai, G., Wang, X.(2025) Sci Bull (Beijing) 
Experimental Data Snapshot
wwPDB Validation   3D Report Full Report
Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Serine/threonine-protein kinase ATR | 2,644 | Homo sapiens | Mutation(s): 0  Gene Names: ATR, FRP1 EC: 2.7.11.1 | ![]() | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q13535 (Homo sapiens) Explore Q13535  Go to UniProtKB:  Q13535 | |||||
PHAROS:  Q13535 GTEx:  ENSG00000175054  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q13535 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 2 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
ATR-interacting protein | C [auth D], D [auth C] | 791 | Homo sapiens | Mutation(s): 0  Gene Names: ATRIP, AGS1 | ![]() |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q8WXE1 (Homo sapiens) Explore Q8WXE1  Go to UniProtKB:  Q8WXE1 | |||||
PHAROS:  Q8WXE1 GTEx:  ENSG00000164053  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q8WXE1 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 1 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
AGS (Subject of Investigation/LOI) Query on AGS | E [auth A], F [auth B] | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER C10 H16 N5 O12 P3 S NLTUCYMLOPLUHL-KQYNXXCUSA-N |
Funding Organization | Location | Grant Number |
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National Natural Science Foundation of China (NSFC) | China | -- |