Download MendeleyDynamic and structural insights into allosteric regulation on MKP5/DUSP10 a dual-specificity phosphatase
Manjula, R., Bennett, A.M., Lolis, E.To be published.
9BPN | pdb_00009bpn
Crystal structure of the allosteric MKP5 mutant Y435W
- PDB DOI: https://doi.org/10.2210/pdb9BPN/pdb
- Classification: HYDROLASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2024-05-07 Released: 2025-05-14
- Funding Organization(s): National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.40 ?
- R-Value Free: 0.288 (Depositor), 0.293 (DCC)
- R-Value Work: 0.226 (Depositor), 0.235 (DCC)
- R-Value Observed: 0.229 (Depositor)
Starting Model: experimental
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wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Dual specificity protein phosphatase 10 | 148 | Homo sapiens | Mutation(s): 1 Gene Names: DUSP10, MKP5 EC: 3.1.3.16 (PDB Primary Data), 3.1.3.48 (PDB Primary Data) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9Y6W6 (Homo sapiens) Explore Q9Y6W6 Go to UniProtKB: Q9Y6W6 | |||||
PHAROS: Q9Y6W6 GTEx: ENSG00000143507 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9Y6W6 | ||||
Sequence AnnotationsExpand | |||||
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Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.40 ?
- R-Value Free: 0.288 (Depositor), 0.293 (DCC)
- R-Value Work: 0.226 (Depositor), 0.235 (DCC)
- R-Value Observed: 0.229 (Depositor)
Space Group: C 1 2 1
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 97.862 | α = 90 |
| b = 44.744 | β = 109.04 |
| c = 87.326 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| Aimless | data scaling |
| XDS | data reduction |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-05-14 Deposition Author(s): Manjula, R., Bennett, A.M., Lolis, E.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) | United States | RO1 HL158876 |
Revision History (Full details and data files)
- Version 1.0: 2025-05-14
Type: Initial release
