Download MendeleyThe structure of SSTR3 and SSTR5 provide insights into the specificity among somatostatin receptos.
Heo, Y., Kim, Y., Cho, M., Kim, C., Ryu, B., Kang, H.J., Lee, W., Yun, J.H.To be published.
8ZBJ | pdb_00008zbj
Cryo-EM structure of Somatostatin receptor 5 (SSTR5) with Gi1 complex
- PDB DOI: https://doi.org/10.2210/pdb8ZBJ/pdb
- EM Map EMD-39903: EMDB EMDataResource
- Classification: MEMBRANE PROTEIN
- Organism(s): Homo sapiens
- Expression System: synthetic construct, Spodoptera frugiperda
- Mutation(s): No
- Deposited: 2024-04-26 Released: 2025-04-30
- Funding Organization(s): Institute for Basic Science
Experimental Data Snapshot
- Method: ELECTRON MICROSCOPY
- Resolution: 2.94 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
Starting Model: experimental
View more details
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by: Sequence | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Somatostatin-14 | A [auth S] | 14 | Homo sapiens | Mutation(s): 0 Gene Names: SST |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P61278 (Homo sapiens) Explore P61278 Go to UniProtKB: P61278 | |||||
PHAROS: P61278 GTEx: ENSG00000157005 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P61278 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | B [auth C] | 345 | Homo sapiens | Mutation(s): 0 Gene Names: GNB1 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P62873 (Homo sapiens) Explore P62873 Go to UniProtKB: P62873 | |||||
PHAROS: P62873 GTEx: ENSG00000078369 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P62873 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | C [auth E] | 71 | Homo sapiens | Mutation(s): 0 Gene Names: GNG2 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P59768 (Homo sapiens) Explore P59768 Go to UniProtKB: P59768 | |||||
PHAROS: P59768 GTEx: ENSG00000186469 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P59768 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 4 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| scFv16 | D [auth F] | 296 | Homo sapiens | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 5 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Soluble cytochrome b562,Somatostatin receptor type 5 | E [auth R] | 470 | Homo sapiens | Mutation(s): 0 Gene Names: cybC, SSTR5 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P0ABE7 (Escherichia coli) Explore P0ABE7 Go to UniProtKB: P0ABE7 | |||||
Find proteins for P35346 (Homo sapiens) Explore P35346 Go to UniProtKB: P35346 | |||||
PHAROS: P35346 GTEx: ENSG00000162009 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Groups | P35346P0ABE7 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 6 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Guanine nucleotide-binding protein G(i) subunit alpha-1 | F [auth A] | 354 | Homo sapiens | Mutation(s): 0 Gene Names: GNAI1 EC: 3.6.5 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P63096 (Homo sapiens) Explore P63096 Go to UniProtKB: P63096 | |||||
PHAROS: P63096 GTEx: ENSG00000127955 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P63096 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Biologically Interesting Molecules (External Reference) 1 Unique
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| ID | Chains | Name | Type/Class | 2D Diagram | 3D Interactions |
| PRD_001216 Query on PRD_001216 | A [auth S] | Somatostatin-14 | Cyclic peptide / Inhibitor |  | |
Experimental Data & Validation
Experimental Data
- Method: ELECTRON MICROSCOPY
- Resolution: 2.94 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
| Task | Software Package | Version |
|---|---|---|
| MODEL REFINEMENT | PHENIX | 1.19.2 |
Entry History & Funding Information
Deposition Data
| Funding Organization | Location | Grant Number |
|---|---|---|
| Institute for Basic Science | Korea, Republic Of | IBS-R021-D1-2024-a00 |
Revision History (Full details and data files)
- Version 1.0: 2025-04-30
Type: Initial release
