Aclacinomycin 10-hydroxylase RdmB

UniProtKB accession:  Q54527

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Involved in the biosynthesis of anthracyclines, an important group of aromatic polyketide antibiotics used in cancer chemotherapy (PubMed:11004563, PubMed:15548527, PubMed:7751313, PubMed:8081500). Acts as a 10-hydroxylase to catalyze a decarboxylative hydroxylation reaction on anthracyclines (PubMed:11004563, PubMed:15548527, PubMed:36874276, PubMed:39308748). During biosynthesis of rhodomycin, it catalyzes the removal of the carboxylic group at the C-10 position of 15-demethoxy-epsilon-rhodomycin coupled to hydroxylation at the same C-10 position to yield beta-rhodomycin (PubMed:15548527). In vitro, can also catalyze the removal of the carboxylic group at the C-10 position of 15-demethoxyaclacinomycin T coupled to hydroxylation at the same C-10 position to yield 10-decarboxymethylaclacinomycin T (PubMed:11004563). It can also use 10-carboxy-13-deoxycarminomycin, an analog of 15-demethoxy-epsilon-rhodomycin, to yield 10-hydroxy-13-deoxycarminomycin (PubMed:39308748).