Variediene synthase

UniProtKB accession:  A0A0P0ZD79

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UniProtKB description:  Bifunctional terpene synthase that converts dimethylallyl diphosphate (DMAPP) and isopentenyl diphosphate (IPP) into variediene as a single product (PubMed:26546087). The C-terminal prenyltransferase (PT) domain of EvVS catalyzes formation of geranylgeranyl pyrophosphate (GGPP), whereas the N-terminal terpene cyclase (TC) domain catalyzes the cyclization of GGPP to variediene (PubMed:26546087). The PT domain can also synthesize geranylfarnesyl pyrophosphate (GFPP) from the C5 isoprene units in vitro, while the TC domain is able to cyclize GFPP to the sesterterpene (2E)-alpha-cericerene (PubMed:26546087).