Annotations: 9QYD

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein mono-ADP-ribosyltransferase PARP9	protein binding binding histone binding nucleoside phosphate binding ion binding ADP-D-ribose binding anion binding heterocyclic compound binding carbohydrate derivative binding small molecule binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding STAT family protein binding protein binding binding histone binding nucleoside phosphate binding ion binding ADP-D-ribose binding anion binding heterocyclic compound binding carbohydrate derivative binding small molecule binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding STAT family protein binding enzyme regulator activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity catalytic activity pentosyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity transferase activity NAD+-protein mono-ADP-ribosyltransferase activity transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity ubiquitin-like protein ligase binding enzyme binding nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups NAD+ poly-ADP-ribosyltransferase activity	protein localization regulation of localization regulation of biological process cellular localization regulation of cellular process regulation of protein localization positive regulation of protein localization to nucleus biological regulation positive regulation of biological process regulation of protein localization to nucleus protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization regulation of localization regulation of biological process cellular localization regulation of cellular process regulation of protein localization positive regulation of protein localization to nucleus biological regulation positive regulation of biological process regulation of protein localization to nucleus protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization cellular process positive regulation of cellular process biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus cellular response to stimulus positive regulation of cell communication positive regulation of response to biotic stimulus positive regulation of signal transduction response to type II interferon response to cytokine regulation of signal transduction regulation of type II interferon-mediated signaling pathway cellular response to type II interferon cell communication interferon-mediated signaling pathway positive regulation of immune response positive regulation of response to type II interferon cellular response to cytokine stimulus regulation of immune system process signal transduction positive regulation of immune system process regulation of innate immune response type II interferon-mediated signaling pathway regulation of response to cytokine stimulus regulation of response to stimulus response to chemical positive regulation of defense response regulation of immune response regulation of response to type II interferon regulation of defense response regulation of response to biotic stimulus positive regulation of type II interferon-mediated signaling pathway regulation of response to external stimulus signaling positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway positive regulation of response to stimulus positive regulation of response to external stimulus regulation of response to stress regulation of signaling cell surface receptor signaling pathway positive regulation of innate immune response regulation of cytokine-mediated signaling pathway response to peptide regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling viral gene expression viral protein processing viral process cell migration cell motility regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process post-transcriptional regulation of gene expression regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of catalytic activity negative regulation of molecular function negative regulation of catalytic activity positive regulation of phosphorylation positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation tyrosine phosphorylation of STAT protein protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process macromolecule modification regulation of phosphorus metabolic process cell surface receptor signaling pathway via STAT regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process protein metabolic process regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of STAT protein regulation of phosphorylation peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of defense response to virus defense response to virus positive regulation of defense response to virus by host regulation of defense response to virus by host response to virus double-strand break repair DNA metabolic process cellular response to stress DNA damage response DNA repair negative regulation of metabolic process negative regulation of biological process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of RNA metabolic process DNA damage checkpoint signaling regulation of cell cycle phase transition negative regulation of cell cycle cell cycle phase transition intracellular signal transduction negative regulation of cell cycle phase transition cell cycle regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling signal transduction in response to DNA damage positive regulation of chromatin binding positive regulation of molecular function regulation of binding positive regulation of binding	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex membraneless organelle site of DNA damage intracellular membraneless organelle chromosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR012317	Poly(ADP-ribose) polymerase, catalytic domain	Domain
A	IPR052056	Mono-ADP-ribosyltransferase ARTD/PARP	Family
A	IPR002589	Macro domain	Domain
A	IPR043472	Macro domain-like	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8IXQ6	pilocytic astrocytoma Sjogren syndrome ulcerative colitis astrocytic tumor breast carcinoma glioblastoma invasive ductal breast carcinoma malignant ependymoma multiple sclerosis pancreatic ductal adenocarcinoma progressive supranuclear palsy subependymal giant cell astrocytoma atopic eczema Crohn disease hepatocellular carcinoma pilocytic astrocytoma Sjogren syndrome ulcerative colitis astrocytic tumor breast carcinoma glioblastoma invasive ductal breast carcinoma malignant ependymoma multiple sclerosis pancreatic ductal adenocarcinoma progressive supranuclear palsy subependymal giant cell astrocytoma atopic eczema Crohn disease hepatocellular carcinoma juvenile dermatomyositis malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis tuberculosis breast cancer cystic fibrosis interstitial cystitis large cell medulloblastoma malignant pancreatic neoplasm ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.