9MOE | pdb_00009moe

Preclinical and clinical evaluation of a novel TRPA1 antagonist LY3526318

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C [auth D], D [auth E]	PF00023	Ankyrin repeat (Ank)	Ankyrin repeat	-	Repeat
A, B, C [auth D], D [auth E]	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C [auth D], D [auth E]	Transient receptor potential cation channel subfamily A member 1	calcium channel activity monoatomic cation transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity intracellularly gated calcium channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity ligand-gated calcium channel activity inorganic cation transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity intracellularly gated calcium channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity ligand-gated calcium channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity ligand-gated monoatomic cation channel activity transmembrane transporter activity temperature-gated ion channel activity temperature-gated cation channel activity identical protein binding protein binding binding	cellular response to food cellular response to stimulus response to nutrient levels cellular response to chemical stimulus response to stimulus response to food response to chemical cellular process response to xenobiotic stimulus multicellular organismal process response to stress multicellular organismal response to stress response to pain detection of external stimulus cellular response to food cellular response to stimulus response to nutrient levels cellular response to chemical stimulus response to stimulus response to food response to chemical cellular process response to xenobiotic stimulus multicellular organismal process response to stress multicellular organismal response to stress response to pain detection of external stimulus detection of stimulus involved in sensory perception of pain system process detection of mechanical stimulus involved in sensory perception of pain nervous system process response to mechanical stimulus response to external stimulus sensory perception of pain detection of mechanical stimulus involved in sensory perception sensory perception of mechanical stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of mechanical stimulus response to abiotic stimulus detection of stimulus involved in sensory perception response to cold response to temperature stimulus localization transport monoatomic ion transport establishment of localization thermoception sensory perception of temperature stimulus protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis sensory perception of chemical stimulus detection of chemical stimulus detection of chemical stimulus involved in sensory perception of pain detection of chemical stimulus involved in sensory perception inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis monoatomic ion transmembrane transport inorganic ion transmembrane transport calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport monoatomic cation transport calcium ion transmembrane transport cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound cellular response to hydrogen peroxide response to reactive oxygen species response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species cellular response to stress regulation of biological process regulation of cellular process cell surface receptor signaling pathway signaling biological regulation signal transduction cell communication	cell periphery cellular anatomical structure plasma membrane membrane stereocilium bundle cluster of actin-based cell projections

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C [auth D], D [auth E]	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A, B, C [auth D], D [auth E]	IPR002110	Ankyrin repeat	Repeat
A, B, C [auth D], D [auth E]	IPR005821	Ion transport domain	Domain
A, B, C [auth D], D [auth E]	IPR052076	Transient receptor potential cation channel	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C [auth D], D [auth E]	Pharos: O75762	familial episodic pain syndrome with predominantly upper body involvement overactive bladder Bronchial Hyperreactivity asthma pain agnosia pancreatic intraductal papillary-mucinous carcinoma cutaneous melanoma malignant colon neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis malignant mesothelioma ovarian cancer psoriasis gastric carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.