9MFG | pdb_00009mfg

Complex of IL23 receptor and VHH

External Resource: Annotation

SAbDab Antibody Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
E, F, G, H	Heavy Chain	IGHV3	-	interleukin-23 receptor	SAbDab (2025-05-23)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Interleukin-23 receptor	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity cytokine receptor activity immune receptor activity protein binding binding cytokine binding amide binding peptide hormone binding hormone binding prolactin receptor activity	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular process cellular response to cytokine stimulus cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular process cellular response to cytokine stimulus signal transduction interleukin-23-mediated signaling pathway adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of T-helper 17 type immune response immune response regulation of adaptive immune response positive regulation of biological process positive regulation of T-helper 17 type immune response adaptive immune response positive regulation of response to stimulus regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of response to stimulus positive regulation of immune response immune system process regulation of immune response regulation of immune system process positive regulation of adaptive immune response positive regulation of immune system process T-helper 17 type immune response cell surface receptor signaling pathway via STAT positive regulation of T-helper 1 type immune response T-helper 1 type immune response regulation of T-helper 1 type immune response multicellular organismal process positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation lymphocyte activation positive regulation of natural killer cell proliferation leukocyte proliferation leukocyte activation positive regulation of lymphocyte activation positive regulation of cell activation lymphocyte proliferation positive regulation of leukocyte activation positive regulation of mononuclear cell proliferation regulation of multicellular organismal process regulation of natural killer cell activation positive regulation of cellular process regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation cell activation positive regulation of lymphocyte proliferation positive regulation of natural killer cell activation natural killer cell activation natural killer cell proliferation mononuclear cell proliferation regulation of cell population proliferation positive regulation of leukocyte proliferation regulation of mononuclear cell proliferation positive regulation of multicellular organismal process regulation of lymphocyte activation regulation of natural killer cell proliferation regulation of interleukin-12 production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production positive regulation of macromolecule metabolic process interleukin-12 production regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of interleukin-12 production regulation of gene expression biosynthetic process positive regulation of gene expression metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process negative regulation of interleukin-10 production negative regulation of biological process interleukin-10 production negative regulation of cellular process regulation of interleukin-10 production negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cytokine production negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process biological process involved in interspecies interaction between organisms response to other organism defense response response to type II interferon defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus cell surface receptor signaling pathway via JAK-STAT T cell activation positive regulation of T cell activation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of leukocyte cell-cell adhesion regulation of activated T cell proliferation positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion activated T cell proliferation positive regulation of cell-cell adhesion cell adhesion cell-cell adhesion regulation of cell-cell adhesion T cell proliferation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation regulation of alpha-beta T cell activation positive regulation of T cell differentiation regulation of cell development alpha-beta T cell differentiation involved in immune response multicellular organism development cell differentiation regulation of T-helper cell differentiation alpha-beta T cell activation positive regulation of CD4-positive, alpha-beta T cell differentiation T-helper cell differentiation alpha-beta T cell lineage commitment positive regulation of cell development immune effector process T-helper 17 cell differentiation cell fate commitment CD4-positive or CD8-positive, alpha-beta T cell lineage commitment positive regulation of alpha-beta T cell differentiation regulation of developmental process cell development CD4-positive, alpha-beta T cell differentiation positive regulation of T-helper 17 cell differentiation positive regulation of T-helper cell differentiation regulation of T cell differentiation alpha-beta T cell differentiation T cell activation involved in immune response positive regulation of cell differentiation leukocyte activation involved in immune response positive regulation of immune effector process regulation of T-helper 17 cell differentiation hemopoiesis regulation of CD4-positive, alpha-beta T cell activation regulation of immune effector process regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation involved in immune response positive regulation of developmental process positive regulation of T-helper 17 cell lineage commitment anatomical structure development T cell differentiation CD4-positive, alpha-beta T cell lineage commitment developmental process T-helper cell lineage commitment T-helper 17 cell lineage commitment positive regulation of alpha-beta T cell activation leukocyte differentiation cellular developmental process regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation positive regulation of CD4-positive, alpha-beta T cell activation alpha-beta T cell activation involved in immune response positive regulation of hemopoiesis CD4-positive, alpha-beta T cell activation lymphocyte activation involved in immune response positive regulation of cell fate commitment regulation of lymphocyte differentiation regulation of multicellular organismal development regulation of T-helper 17 cell lineage commitment regulation of cell fate commitment T cell differentiation involved in immune response T cell lineage commitment positive T cell selection regulation of hemopoiesis positive regulation of leukocyte differentiation T cell selection positive regulation of lymphocyte differentiation granulocyte macrophage colony-stimulating factor production positive regulation of protein metabolic process positive regulation of granulocyte macrophage colony-stimulating factor production regulation of primary metabolic process protein metabolic process regulation of granulocyte macrophage colony-stimulating factor production regulation of protein metabolic process primary metabolic process regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus regulation of defense response to virus defense response to virus regulation of response to stress positive regulation of defense response to virus by host regulation of defense response to virus by host response to virus interleukin-17 production regulation of interleukin-17 production positive regulation of interleukin-17 production defense response to Gram-negative bacterium defense response to bacterium response to bacterium positive regulation of NK T cell activation regulation of NK T cell activation NK T cell activation inflammatory response lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity positive regulation of lymphocyte mediated immunity positive regulation of leukocyte mediated cytotoxicity leukocyte mediated immunity regulation of T cell mediated immunity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity regulation of leukocyte mediated immunity regulation of T cell mediated cytotoxicity regulation of lymphocyte mediated immunity positive regulation of T cell mediated immunity regulation of cell killing positive regulation of cell killing cell killing immunological memory formation process positive regulation of memory T cell differentiation memory T cell differentiation regulation of memory T cell differentiation immunological memory process response to lipid response to oxygen-containing compound response to lipopolysaccharide response to molecule of bacterial origin regulation of type II interferon production type II interferon production positive regulation of type II interferon production myeloid leukocyte differentiation positive regulation of osteoclast differentiation regulation of osteoclast differentiation osteoclast differentiation regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation positive regulation of myeloid cell differentiation	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex receptor complex plasma membrane protein complex interleukin-23 receptor complex plasma membrane signaling receptor complex membrane protein complex
E, F, G, H	VHH	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003961	Fibronectin type III	Domain
A, B, C, D	IPR052672	Type I Cytokine Receptor Family, Type 2 Subfamily	Family
A, B, C, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C, D	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q5VWK5	ankylosing spondylitis ulcerative colitis psoriasis Crohn disease inflammatory bowel disease leprosy inflammatory bowel disease 17 psoriatic arthritis Behcet disease Vogt-Koyanagi-Harada disease Pustulosis of Palms and Soles rheumatoid arthritis bowel dysfunction Crohn's colitis ileocolitis ankylosing spondylitis ulcerative colitis psoriasis Crohn disease inflammatory bowel disease leprosy inflammatory bowel disease 17 psoriatic arthritis Behcet disease Vogt-Koyanagi-Harada disease Pustulosis of Palms and Soles rheumatoid arthritis bowel dysfunction Crohn's colitis ileocolitis myositis pustulosis palmaris et plantaris systemic lupus erythematosus anterior uveitis common variable immunodeficiency intestinal disease ovarian cancer systemic sclerosis inflammatory bowel disease 1 primary biliary cholangitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.