Annotations: 9I8A

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	Nuclear RNA export factor 1	RNA binding binding nucleic acid binding mRNA binding	cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process protein localization establishment of protein localization protein transport cellular macromolecule localization poly(A)+ mRNA export from nucleus	intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule membrane-bounded organelle nucleus membrane-enclosed lumen intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen cytosol protein-containing complex nuclear protein-containing complex endomembrane system organelle envelope nuclear envelope nuclear pore nuclear RNA export factor complex inclusion body nuclear inclusion body
B [auth A]	NTF2-related export protein 1	small GTPase binding protein binding binding enzyme binding GTPase binding	cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process protein localization establishment of protein localization protein export from nucleus protein transport cellular macromolecule localization intracellular protein transport	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex nuclear protein-containing complex endomembrane system organelle envelope nuclear envelope nuclear pore nuclear pore central transport channel cytoplasm cytosol nuclear RNA export factor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR030217	Nuclear RNA export factor	Family
A [auth B]	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
A [auth B]	IPR015245	Nuclear RNA export factor Tap, RNA-binding domain	Domain
A [auth B]	IPR005637	TAP C-terminal (TAP-C) domain	Domain
A [auth B]	IPR001611	Leucine-rich repeat	Repeat
A [auth B]	IPR018222	Nuclear transport factor 2, eukaryote	Domain
A [auth B]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
A [auth B]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A [auth B]	IPR009060	UBA-like superfamily	Homologous Superfamily
A [auth B]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
A [auth B]	IPR002075	Nuclear transport factor 2 domain	Domain
B [auth A]	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
B [auth A]	IPR045875	Nuclear transport factor 2	Family
B [auth A]	IPR018222	Nuclear transport factor 2, eukaryote	Domain
B [auth A]	IPR002075	Nuclear transport factor 2 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B]	Pharos: Q9UBU9	acute myeloid leukemia
B [auth A]	Pharos: Q9UKK6	breast cancer invasive ductal breast carcinoma malignant pancreatic neoplasm primitive neuroectodermal tumor glioblastoma large cell medulloblastoma medulloblastoma Sjogren syndrome hepatocellular carcinoma malignant mesothelioma pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.