Annotations: 9EJY

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Heterogeneous nuclear ribonucleoprotein R	RNA binding binding nucleic acid binding mRNA binding	RNA splicing RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen endoplasmic reticulum cytoplasm endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR034411	Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2	Domain
A	IPR000504	RNA recognition motif domain	Domain
A	IPR006535	HnRNP R/Q splicing factor	Family
A	IPR041337	Heterogeneous nuclear ribonucleoprotein Q acidic domain	Domain
A	IPR034410	Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 1	Domain
A	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
A	IPR035979	RNA-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O43390	breast carcinoma breast cancer Pick disease amyotrophic lateral sclerosis cystic fibrosis large cell medulloblastoma lymphoplasmacytic lymphoma Mammary Neoplasms myopathy ovarian cancer plasma cell myeloma dermatomyositis lung adenocarcinoma malignant ependymoma oligodendroglioma breast carcinoma breast cancer Pick disease amyotrophic lateral sclerosis cystic fibrosis large cell medulloblastoma lymphoplasmacytic lymphoma Mammary Neoplasms myopathy ovarian cancer plasma cell myeloma dermatomyositis lung adenocarcinoma malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma psoriasis juvenile dermatomyositis lung cancer medulloblastoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.