9EGO | pdb_00009ego

Cannabinoid receptor 1-Gi complex with novel ligand

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	protein binding binding G-protein beta-subunit binding	fibroblast proliferation cell population proliferation cellular process cellular response to nitrogen compound cellular response to stimulus response to dopamine regulation of cellular process response to stimulus signaling cellular response to dopamine response to monoamine cell communication response to catecholamine adenylate cyclase-activating dopamine receptor signaling pathway fibroblast proliferation cell population proliferation cellular process cellular response to nitrogen compound cellular response to stimulus response to dopamine regulation of cellular process response to stimulus signaling cellular response to dopamine response to monoamine cell communication response to catecholamine adenylate cyclase-activating dopamine receptor signaling pathway cellular response to catecholamine stimulus signal transduction regulation of biological process G protein-coupled dopamine receptor signaling pathway biological regulation response to oxygen-containing compound response to nitrogen compound adenylate cyclase-activating G protein-coupled receptor signaling pathway cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to monoamine stimulus response to chemical adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway response to ketone response to prostaglandin response to lipid response to endogenous stimulus response to alcohol cellular response to prostaglandin stimulus cellular response to endogenous stimulus cellular response to prostaglandin E stimulus cellular response to alcohol response to hormone cellular response to lipid response to prostaglandin E cellular response to ketone cellular response to hormone stimulus	cellular anatomical structure membrane protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cell periphery cytoplasmic side of plasma membrane GTPase complex cellular anatomical structure membrane protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cell periphery cytoplasmic side of plasma membrane GTPase complex extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle synapse cell junction
A	Guanine nucleotide-binding protein G(i) subunit alpha-1	D2 dopamine receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding dopamine receptor binding phosphorus-oxygen lyase activity enzyme regulator activity cyclase regulator activity molecular function regulator activity cyclase activity adenylate cyclase regulator activity lyase activity catalytic activity D2 dopamine receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding dopamine receptor binding phosphorus-oxygen lyase activity enzyme regulator activity cyclase regulator activity molecular function regulator activity cyclase activity adenylate cyclase regulator activity lyase activity catalytic activity adenylate cyclase activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding magnesium ion binding metal ion binding GDP binding G protein-coupled serotonin receptor binding protein-containing complex binding G-protein beta/gamma-subunit complex binding pyrophosphatase activity GTPase activity G protein activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation adenylate cyclase-inhibiting serotonin receptor signaling pathway G protein-coupled serotonin receptor signaling pathway cell communication adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation adenylate cyclase-inhibiting serotonin receptor signaling pathway G protein-coupled serotonin receptor signaling pathway cell communication adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction response to hormone response to chemical response to endogenous stimulus response to peptide hormone response to oxygen-containing compound response to nitrogen compound cell division leukocyte migration immune system process mononuclear cell migration lymphocyte migration cell migration T cell migration cell motility regulation of steroid biosynthetic process regulation of cholesterol biosynthetic process regulation of cholesterol metabolic process steroid metabolic process regulation of lipid metabolic process sterol metabolic process positive regulation of biological process cholesterol metabolic process lipid biosynthetic process alcohol metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of small molecule metabolic process positive regulation of biosynthetic process positive regulation of lipid metabolic process small molecule metabolic process steroid biosynthetic process positive regulation of cellular process regulation of biosynthetic process secondary alcohol biosynthetic process regulation of alcohol biosynthetic process small molecule biosynthetic process regulation of steroid metabolic process cholesterol biosynthetic process positive regulation of cholesterol biosynthetic process primary metabolic process secondary alcohol metabolic process positive regulation of steroid biosynthetic process biosynthetic process sterol biosynthetic process positive regulation of lipid biosynthetic process regulation of sterol biosynthetic process alcohol biosynthetic process positive regulation of cholesterol metabolic process positive regulation of steroid metabolic process metabolic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process regulation of metabolic process positive regulation of alcohol biosynthetic process positive regulation of sterol biosynthetic process lipid metabolic process regulation of cytoskeleton organization regulation of cellular component organization microtubule cytoskeleton organization regulation of mitotic spindle organization mitotic cell cycle cellular component organization cell cycle cellular component organization or biogenesis regulation of cell cycle microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process regulation of cell cycle process regulation of microtubule-based process regulation of spindle organization regulation of organelle organization mitotic spindle organization organelle organization mitotic cell cycle process microtubule-based process cytoskeleton organization regulation of microtubule cytoskeleton organization protein localization positive regulation of protein localization to cell periphery regulation of localization protein localization to cell periphery cellular localization regulation of protein localization positive regulation of protein localization to cell cortex regulation of protein localization to cell periphery localization regulation of cellular localization regulation of protein localization to cell cortex cellular macromolecule localization macromolecule localization positive regulation of protein localization protein localization to cell cortex response to ketone response to prostaglandin response to lipid response to alcohol response to prostaglandin E cellular response to forskolin cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol response to forskolin cellular response to lipid cellular response to ketone	midbody cellular anatomical structure membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle midbody cellular anatomical structure membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen cell periphery cell cortex cytoplasm protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cytoplasmic side of plasma membrane GTPase complex extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton centriolar satellite cytosol nucleoplasm vacuolar membrane lytic vacuole vacuole lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane lysosome Golgi apparatus endomembrane system cilium plasma membrane bounded cell projection ciliary basal body cell projection
B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	protein binding binding enzyme binding GTPase binding protein-containing complex binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity signaling receptor complex adaptor activity protein-macromolecule adaptor activity protein binding binding enzyme binding GTPase binding protein-containing complex binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity signaling receptor complex adaptor activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity	multicellular organismal process system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of taste developmental process sensory organ development eye development animal organ development retina development in camera-type eye visual system development multicellular organism development camera-type eye development multicellular organismal process system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of taste developmental process sensory organ development eye development animal organ development retina development in camera-type eye visual system development multicellular organism development camera-type eye development anatomical structure development sensory system development system development cell population proliferation cellular process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction cell communication response to ketone response to prostaglandin response to lipid response to endogenous stimulus response to alcohol cellular response to prostaglandin stimulus response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to prostaglandin E stimulus cellular response to chemical stimulus cellular response to alcohol response to hormone response to chemical cellular response to lipid response to prostaglandin E cellular response to ketone cellular response to hormone stimulus small GTPase-mediated signal transduction Ras protein signal transduction intracellular signal transduction intracellular signaling cassette phospholipase C-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular response to nitrogen compound response to dopamine cellular response to dopamine response to monoamine response to catecholamine adenylate cyclase-activating dopamine receptor signaling pathway cellular response to catecholamine stimulus G protein-coupled dopamine receptor signaling pathway response to nitrogen compound adenylate cyclase-activating G protein-coupled receptor signaling pathway cellular response to monoamine stimulus adenylate cyclase-modulating G protein-coupled receptor signaling pathway synaptic signaling cellular response to acetylcholine cell-cell signaling acetylcholine receptor signaling pathway postsynaptic signal transduction G protein-coupled acetylcholine receptor signaling pathway response to acetylcholine	cellular anatomical structure membrane protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cell periphery cytoplasmic side of plasma membrane GTPase complex cellular anatomical structure membrane protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cell periphery cytoplasmic side of plasma membrane GTPase complex extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle non-motile cilium 9+0 non-motile cilium cilium neuron projection photoreceptor disc membrane photoreceptor outer segment plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle membrane intracellular anatomical structure cytoplasm cytosol vacuolar membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle lysosomal membrane lysosome synapse cell junction
D [auth R]	Cannabinoid receptor 1	identical protein binding protein binding binding molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity cannabinoid receptor activity	developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation multicellular organismal process regulation of biological process regulation of penile erection regulation of reproductive process biological regulation mating behavior developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation multicellular organismal process regulation of biological process regulation of penile erection regulation of reproductive process biological regulation mating behavior behavior reproductive behavior regulation of multicellular organismal process penile erection copulation positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process system process learning or memory nervous system process cognition memory monoamine transport regulation of localization nitrogen compound transport negative regulation of amine transport regulation of catecholamine secretion transport signaling negative regulation of biological process negative regulation of transport organic hydroxy compound transport dopamine transport cell communication localization secretion by cell regulation of secretion by cell negative regulation of secretion catecholamine transport negative regulation of dopamine secretion signal release negative regulation of cellular process negative regulation of secretion by cell secretion regulation of transport export from cell cell-cell signaling negative regulation of catecholamine secretion dopamine secretion establishment of localization regulation of secretion catecholamine secretion amine transport regulation of amine transport regulation of dopamine secretion regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process cell projection organization cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development cell differentiation anatomical structure development positive regulation of cell projection organization cellular component organization or biogenesis system development plasma membrane bounded cell projection organization regulation of cell projection organization nervous system development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization metabolic process regulation of metabolic process protein localization establishment of protein localization cellular macromolecule localization regulation of biological quality regulation of peptide hormone secretion regulation of hormone levels establishment of protein localization to extracellular region protein secretion regulation of protein secretion cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion hormone secretion protein localization to extracellular region peptide secretion amide transport regulation of signaling regulation of peptide transport regulation of establishment of protein localization regulation of protein transport peptide transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport regulation of cell communication insulin secretion positive regulation of acute inflammatory response to antigenic stimulus regulation of defense response regulation of acute inflammatory response to antigenic stimulus response to stimulus regulation of response to external stimulus positive regulation of acute inflammatory response inflammatory response to antigenic stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response positive regulation of immune response response to stress regulation of response to stress regulation of immune system process acute inflammatory response positive regulation of immune system process defense response immune response regulation of inflammatory response to antigenic stimulus response to external stimulus regulation of inflammatory response positive regulation of inflammatory response to antigenic stimulus acute inflammatory response to antigenic stimulus regulation of response to stimulus immune system process positive regulation of defense response regulation of acute inflammatory response regulation of immune response inflammatory response neuron recognition neuron projection fasciculation axonal fasciculation cell recognition axon development inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis regulation of cytosolic calcium ion concentration regulation of presynaptic cytosolic calcium ion concentration cellular homeostasis neuron cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of behavior feeding behavior regulation of feeding behavior glucose homeostasis carbohydrate homeostasis cellular response to stimulus G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger G protein-coupled receptor signaling pathway signal transduction cannabinoid signaling pathway negative regulation of monoatomic ion transport monoatomic ion transport serotonin secretion negative regulation of serotonin secretion regulation of monoatomic ion transport serotonin transport regulation of serotonin secretion trans-synaptic signaling synaptic transmission, GABAergic modulation of chemical synaptic transmission chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of synaptic transmission, GABAergic multi-multicellular organism process maternal process involved in female pregnancy female pregnancy multi-organism reproductive process circulatory system process regulation of blood pressure positive regulation of blood pressure blood circulation adenylate cyclase-modulating G protein-coupled receptor signaling pathway response to alcohol response to chemical response to oxygen-containing compound response to ethanol adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of action potential negative regulation of action potential action potential regulation of membrane potential trans-synaptic signaling by endocannabinoid retrograde trans-synaptic signaling retrograde trans-synaptic signaling by endocannabinoid trans-synaptic signaling by lipid retrograde trans-synaptic signaling by lipid regulation of leukocyte activation cell activation regulation of cell activation myeloid leukocyte activation leukocyte activation negative regulation of cell activation negative regulation of mast cell activation negative regulation of immune system process mast cell activation regulation of mast cell activation negative regulation of multicellular organismal process negative regulation of leukocyte activation synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic response to nutrient levels response to nutrient response to nicotine biological process involved in interspecies interaction between organisms response to lipid response to other organism response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin response to nitrogen compound response to cocaine response to alkaloid acute-phase response regulation of heat generation positive regulation of heat generation heat generation positive regulation of fever generation fever generation multicellular organismal-level homeostasis temperature homeostasis positive regulation of multicellular organismal process regulation of fever generation negative regulation of blood pressure catabolic process negative regulation of fatty acid oxidation negative regulation of small molecule metabolic process negative regulation of fatty acid beta-oxidation oxoacid metabolic process ketone metabolic process regulation of lipid metabolic process organic acid metabolic process organic acid catabolic process regulation of primary metabolic process regulation of fatty acid oxidation monocarboxylic acid catabolic process fatty acid oxidation regulation of small molecule metabolic process carboxylic acid catabolic process fatty acid beta-oxidation small molecule metabolic process lipid oxidation negative regulation of lipid catabolic process negative regulation of catabolic process fatty acid metabolic process lipid catabolic process negative regulation of fatty acid metabolic process negative regulation of metabolic process regulation of fatty acid beta-oxidation carboxylic acid metabolic process primary metabolic process lipid modification regulation of catabolic process regulation of lipid catabolic process regulation of ketone metabolic process fatty acid catabolic process regulation of fatty acid metabolic process monocarboxylic acid metabolic process small molecule catabolic process negative regulation of lipid metabolic process lipid metabolic process	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cell periphery presynapse synapse cell junction membrane plasma membrane intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cell periphery presynapse synapse cell junction membrane plasma membrane presynaptic membrane plasma membrane region synaptic membrane cytoplasm glutamatergic synapse membrane-bounded organelle mitochondrial membrane mitochondrion organelle outer membrane intracellular membrane-bounded organelle organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane membrane microdomain membrane raft growth cone axon cell projection distal axon neuron projection plasma membrane bounded cell projection site of polarized growth GABA-ergic synapse
E [auth S]	scFv16	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C	IPR015898	G-protein gamma-like domain	Domain
C	IPR001770	G-protein, gamma subunit	Family
C	IPR036284	G-protein gamma-like domain superfamily	Homologous Superfamily
A	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit	Family
A	IPR011025	G protein alpha subunit, helical insertion	Homologous Superfamily
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR001408	G-protein alpha subunit, group I	Family
B	IPR019775	WD40 repeat, conserved site	Conserved Site
B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B	IPR016346	Guanine nucleotide-binding protein, beta subunit	Family
B	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
B	IPR001632	G-protein, beta subunit	Domain
B	IPR001680	WD40 repeat	Repeat
B	IPR020472	G-protein beta WD-40 repeat	Repeat
D [auth R]	IPR000810	Cannabinoid receptor type 1	Family
D [auth R]	IPR002230	Cannabinoid receptor family	Family
D [auth R]	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
D [auth R]	IPR017452	GPCR, rhodopsin-like, 7TM	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C	Pharos: P59768	pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma sarcoidosis ulcerative colitis adrenal cortex carcinoma breast carcinoma Duchenne muscular dystrophy glioblastoma large cell medulloblastoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer Sjogren syndrome X-linked mixed deafness with perilymphatic gusher pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma sarcoidosis ulcerative colitis adrenal cortex carcinoma breast carcinoma Duchenne muscular dystrophy glioblastoma large cell medulloblastoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer Sjogren syndrome X-linked mixed deafness with perilymphatic gusher astrocytic tumor Crohn disease ductal breast carcinoma in situ interstitial cystitis lung carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma Pick disease primitive neuroectodermal tumor thoracic aortic aneurysm atypical teratoid rhabdoid tumor cystic fibrosis Emery-Dreifuss muscular dystrophy invasive ductal breast carcinoma malignant ependymoma osteosarcoma
A	Pharos: P63096	substance withdrawal syndrome dissociative amnesia malignant glioma nicotine dependence pancreatic ductal adenocarcinoma acute myeloid leukemia Withdrawal Symptoms breast cancer glioblastoma intellectual disability large cell medulloblastoma malignant pancreatic neoplasm oligodendroglioma Pick disease astrocytic tumor substance withdrawal syndrome dissociative amnesia malignant glioma nicotine dependence pancreatic ductal adenocarcinoma acute myeloid leukemia Withdrawal Symptoms breast cancer glioblastoma intellectual disability large cell medulloblastoma malignant pancreatic neoplasm oligodendroglioma Pick disease astrocytic tumor breast carcinoma interstitial cystitis malignant colon neoplasm medulloblastoma ovarian cancer subependymal giant cell astrocytoma amnestic disorder atypical teratoid rhabdoid tumor breast fibroadenoma ductal breast carcinoma in situ invasive ductal breast carcinoma
B	Pharos: P62873	intellectual disability, autosomal dominant 42 melancholia intellectual disability endogenous depression medulloblastoma myopathy ovarian cancer Precursor Cell Lymphoblastic Leukemia Lymphoma anxiety disorder Sjogren syndrome chronic kidney disease juvenile dermatomyositis lung adenocarcinoma neurotic disorder pancreatic ductal adenocarcinoma intellectual disability, autosomal dominant 42 melancholia intellectual disability endogenous depression medulloblastoma myopathy ovarian cancer Precursor Cell Lymphoblastic Leukemia Lymphoma anxiety disorder Sjogren syndrome chronic kidney disease juvenile dermatomyositis lung adenocarcinoma neurotic disorder pancreatic ductal adenocarcinoma subependymal giant cell astrocytoma breast cancer Duchenne muscular dystrophy leukemia, acute lymphocytic, susceptibility to, 1 malignant pancreatic neoplasm myelodysplastic syndrome osteosarcoma plasma cell myeloma rheumatoid arthritis swine influenza childhood acute lymphoblastic leukemia depressive disorder
D [auth R]	Pharos: P21554	obesity disorder cannabis dependence pancreatitis rhabdomyosarcoma status epilepticus Huntington disease Pain temporal lobe epilepsy cocaine abuse visual epilepsy endometriosis substance withdrawal syndrome cirrhosis of liver cocaine dependence multiple sclerosis obesity disorder cannabis dependence pancreatitis rhabdomyosarcoma status epilepticus Huntington disease Pain temporal lobe epilepsy cocaine abuse visual epilepsy endometriosis substance withdrawal syndrome cirrhosis of liver cocaine dependence multiple sclerosis schizophrenia cutaneous melanoma lung adenocarcinoma malignant colon neoplasm bipolar disorder malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous neoplasm medulloblastoma common cold anxiety disorder depressive disorder drug dependence oligodendroglioma large cell medulloblastoma attention deficit hyperactivity disorder, inattentive type ovarian cancer lung cancer binge eating disorder malignant ependymoma breast cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia monogenic obesity psoriasis Alzheimer disease interstitial cystitis ductal breast carcinoma in situ substance dependence atypical teratoid rhabdoid tumor substance-related disorder major depressive disorder pancreatic intraductal papillary-mucinous carcinoma pancreatic neoplasm glioblastoma tuberculosis migraine disorder pituitary cancer adenoma movement disorder allergic rhinitis hypotensive disorder non-small cell lung carcinoma invasive ductal breast carcinoma astrocytic tumor substance abuse juvenile Huntington disease osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.