9DKE | pdb_00009dke

CryoEM structures of yeast cytoplasmic dynein in the presence of ATP and Lis1.

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Dynein heavy chain, cytoplasmic	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding dynein light intermediate chain binding protein binding microtubule motor activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity minus-end-directed microtubule motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides dynein intermediate chain binding	establishment of organelle localization cellular localization organelle transport along microtubule transport nucleus localization intracellular transport establishment of localization localization organelle localization establishment of localization in cell nuclear migration along microtubule microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport establishment of organelle localization cellular localization organelle transport along microtubule transport nucleus localization intracellular transport establishment of localization localization organelle localization establishment of localization in cell nuclear migration along microtubule microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport cellular process microtubule-based movement microtubule-based process nuclear migration organelle fusion cellular component organization organelle organization nucleus organization karyogamy cellular component organization or biogenesis microtubule cytoskeleton organization spindle localization mitotic cell cycle establishment of mitotic spindle localization mitotic cell cycle process establishment of spindle localization cell cycle microtubule cytoskeleton organization involved in mitosis cytoskeleton organization cell cycle process mitotic nuclear division organelle fission chromosome organization sister chromatid segregation nuclear division mitotic sister chromatid segregation nuclear chromosome segregation chromosome segregation cytoplasmic microtubule organization supramolecular fiber organization establishment or maintenance of cell polarity establishment of spindle orientation establishment of cell polarity establishment of mitotic spindle orientation mitotic spindle organization spindle organization	cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm polymeric cytoskeletal fiber spindle aster astral microtubule intracellular membraneless organelle spindle microtubule cytoplasmic microtubule intracellular organelle cytoskeleton cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm polymeric cytoskeletal fiber spindle aster astral microtubule intracellular membraneless organelle spindle microtubule cytoplasmic microtubule intracellular organelle cytoskeleton organelle membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton microtubule organizing center spindle pole body protein-containing complex cytoplasmic dynein complex catalytic complex dynein complex microtubule associated complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR026983	Dynein heavy chain	Family
A	IPR013602	Dynein heavy chain, linker	Domain
A	IPR035706	Dynein heavy chain, ATP-binding dynein motor region	Domain
A	IPR054354	Dynein 2 heavy chain 1, cytoplasmic, ATPase lid domain	Domain
A	IPR003593	AAA+ ATPase domain	Domain
A	IPR041658	Dynein heavy chain AAA lid domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR042228	Dynein heavy chain, linker, subdomain 3	Homologous Superfamily
A	IPR035699	Dynein heavy chain, hydrolytic ATP-binding dynein motor region	Domain
A	IPR042219	Dynein heavy chain AAA lid domain superfamily	Homologous Superfamily
A	IPR024743	Dynein heavy chain, coiled coil stalk	Domain
A	IPR013594	Dynein heavy chain, tail	Domain
A	IPR048404	DYN1, AAA+ ATPase lid domain	Domain
A	IPR043157	Dynein heavy chain, AAA1 domain, small subdomain	Homologous Superfamily
A	IPR042222	Dynein heavy chain, domain 2, N-terminal	Homologous Superfamily
A	IPR004273	Dynein heavy chain region D6 P-loop domain	Domain
A	IPR024317	Dynein heavy chain, AAA module D4	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.