Annotations: 9DFT

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Aggrecan core protein	binding carbohydrate binding structural molecule activity extracellular matrix structural constituent glycosaminoglycan binding carbohydrate derivative binding hyaluronic acid binding cation binding ion binding metal ion binding small molecule binding	developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development skeletal system development cell adhesion cellular process proteolysis metabolic process primary metabolic process protein metabolic process developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development skeletal system development cell adhesion cellular process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen lytic vacuole vacuolar lumen vacuole intracellular membrane-bounded organelle lysosomal lumen intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen lytic vacuole vacuolar lumen vacuole intracellular membrane-bounded organelle lysosomal lumen intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm lysosome cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix Golgi apparatus endomembrane system Golgi lumen perisynaptic extracellular matrix synapse-associated extracellular matrix perineuronal net specialized extracellular matrix extracellular region synapse cell junction extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B	IPR016187	C-type lectin fold	Homologous Superfamily
A, B	IPR001304	C-type lectin-like	Domain
A, B	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A, B	IPR013106	Immunoglobulin V-set domain	Domain
A, B	IPR003599	Immunoglobulin domain subtype	Domain
A, B	IPR000436	Sushi/SCR/CCP domain	Domain
A, B	IPR000742	EGF-like domain	Domain
A, B	IPR050691	Hyaluronan-binding Proteoglycan	Family
A, B	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A, B	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
A, B	IPR000538	Link domain	Domain
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR018378	C-type lectin, conserved site	Conserved Site
A, B	IPR007110	Immunoglobulin-like domain	Domain
A, B	IPR033987	Aggrecan/versican, C-type lectin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P16112	osteochondritis dissecans spondyloepimetaphyseal dysplasia, aggrecan type spondyloepiphyseal dysplasia, Kimberley type rheumatoid arthritis bagassosis intervertebral disc degenerative disorder pneumoconiosis intellectual disability large cell medulloblastoma oligodendroglioma osteochondrodysplasia ovarian cancer spondyloepiphyseal dysplasia synovitis facioscapulohumeral muscular dystrophy osteochondritis dissecans spondyloepimetaphyseal dysplasia, aggrecan type spondyloepiphyseal dysplasia, Kimberley type rheumatoid arthritis bagassosis intervertebral disc degenerative disorder pneumoconiosis intellectual disability large cell medulloblastoma oligodendroglioma osteochondrodysplasia ovarian cancer spondyloepiphyseal dysplasia synovitis facioscapulohumeral muscular dystrophy interstitial cystitis malignant glioma osteoarthritis osteogenesis imperfecta pilocytic astrocytoma short stature-advanced bone age-early-onset osteoarthritis syndrome spondyloepiphyseal dysplasia with congenital joint dislocations X-linked mixed deafness with perilymphatic gusher Familial Osteochondritis Dissecans osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.