Annotations: 9BHG

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Protein arginine N-methyltransferase 1	histone H2A Q104 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups protein-glutamine N-methyltransferase activity transferase activity S-adenosylmethionine-dependent methyltransferase activity histone methyltransferase activity N-methyltransferase activity protein methyltransferase activity histone modifying activity methyltransferase activity catalytic activity histone H2A methyltransferase activity protein-lysine N-methyltransferase activity histone H2A Q104 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups protein-glutamine N-methyltransferase activity transferase activity S-adenosylmethionine-dependent methyltransferase activity histone methyltransferase activity N-methyltransferase activity protein methyltransferase activity histone modifying activity methyltransferase activity catalytic activity histone H2A methyltransferase activity protein-lysine N-methyltransferase activity histone H3 methyltransferase activity histone H3K37 methyltransferase activity lysine N-methyltransferase activity arginine N-methyltransferase activity protein-arginine N-methyltransferase activity histone H3R26 methyltransferase activity histone H3R17 methyltransferase activity histone H4 methyltransferase activity histone H4K12 methyltransferase activity protein-arginine omega-N monomethyltransferase activity sequence-specific DNA binding DNA binding binding nucleoside phosphate binding nucleotide binding nucleic acid binding heterocyclic compound binding methyl-CpG binding small molecule binding identical protein binding protein binding protein-containing complex binding GATOR1 complex binding cation binding ion binding S-adenosyl-L-methionine binding sulfur compound binding histone H3K56 methyltransferase activity histone H3R2 methyltransferase activity RNA binding histone H4R3 methyltransferase activity kinase binding enzyme binding mitogen-activated protein kinase p38 binding protein kinase binding mitogen-activated protein kinase binding histone H3R8 methyltransferase activity protein-arginine omega-N asymmetric methyltransferase activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process viral gene expression viral protein processing viral process regulation of cellular process positive regulation of protein metabolic process positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of hemoglobin biosynthetic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process viral gene expression viral protein processing viral process regulation of cellular process positive regulation of protein metabolic process positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of hemoglobin biosynthetic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process hemoglobin metabolic process regulation of biosynthetic process regulation of biological process hemoglobin biosynthetic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process macromolecule biosynthetic process biosynthetic process regulation of hemoglobin biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development cellular developmental process regulation of developmental process regulation of megakaryocyte differentiation megakaryocyte differentiation cell development regulation of cell differentiation regulation of cell development cell differentiation regulation of immune system process regulation of multicellular organismal process regulation of multicellular organismal development hemopoiesis regulation of myeloid cell differentiation myeloid cell differentiation immune system process regulation of hemopoiesis cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction cell communication cellular response to endogenous stimulus signal transduction BMP signaling pathway enzyme-linked receptor protein signaling pathway cellular response to BMP stimulus regulation of signaling regulation of BMP signaling pathway cell surface receptor signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus response to BMP regulation of response to stimulus regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway RNA splicing RNA metabolic process gene expression nucleobase-containing compound biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process RNA processing regulation of DNA recombination regulation of double-strand break repair regulation of cellular response to stress positive regulation of double-strand break repair via homologous recombination positive regulation of response to stimulus positive regulation of DNA repair regulation of response to stress recombinational repair regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination DNA repair positive regulation of DNA recombination double-strand break repair positive regulation of nucleobase-containing compound metabolic process DNA recombination DNA metabolic process positive regulation of double-strand break repair regulation of DNA repair regulation of double-strand break repair via homologous recombination positive regulation of DNA metabolic process regulation of DNA metabolic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process regulation of gene expression regulation of DNA-templated transcription homeostatic process positive regulation of developmental process positive regulation of cell differentiation myeloid cell homeostasis erythrocyte homeostasis erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation multicellular organismal-level homeostasis positive regulation of myeloid cell differentiation homeostasis of number of cells heart development cardiac muscle tissue development animal organ development tissue development striated muscle tissue development circulatory system development muscle tissue development system development plasma membrane bounded cell projection organization cell projection organization neuron projection development nervous system development cellular component organization generation of neurons neurogenesis neuron differentiation neuron development cellular component organization or biogenesis negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process intracellular signal transduction negative regulation of cell communication negative regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette negative regulation of cellular process negative regulation of response to stimulus regulation of JNK cascade regulation of MAPK cascade negative regulation of signal transduction MAPK cascade negative regulation of MAPK cascade negative regulation of megakaryocyte differentiation negative regulation of cell differentiation negative regulation of developmental process negative regulation of myeloid cell differentiation positive regulation of cell communication positive regulation of signal transduction positive regulation of TORC1 signaling positive regulation of TOR signaling regulation of TORC1 signaling TOR signaling regulation of TOR signaling positive regulation of intracellular signal transduction TORC1 signaling positive regulation of signaling cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of translation post-transcriptional regulation of gene expression translation positive regulation of gene expression regulation of translation cellular response to methionine cellular response to acid chemical cellular response to nitrogen compound cellular response to amino acid stimulus response to nutrient levels response to nutrient response to oxygen-containing compound response to nitrogen compound response to amino acid cellular response to oxygen-containing compound cellular response to nutrient levels response to acid chemical cellular response to chemical stimulus response to methionine response to chemical cellular response to nutrient protein methylation macromolecule methylation protein alkylation methylation macromolecule modification protein modification process p38MAPK cascade positive regulation of MAPK cascade positive regulation of p38MAPK cascade regulation of p38MAPK cascade cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization peptidyl-arginine methylation peptidyl-amino acid modification peptidyl-arginine modification chromatin organization chromatin remodeling	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol vacuolar membrane membrane-bounded organelle membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol vacuolar membrane membrane-bounded organelle membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle lysosomal membrane organelle membrane lysosome nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex catalytic complex methylosome methyltransferase complex transferase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR055135	Protein arginine N-methyltransferase domain	Domain
A, B, C, D	IPR025799	Protein arginine N-methyltransferase	Family
A, B, C, D	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A, B, C, D	IPR041698	Methyltransferase domain 25	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q99873	dermatomyositis Hodgkins lymphoma lung cancer myositis rheumatoid arthritis systemic sclerosis diabetes mellitus hypothyroidism malignant colon neoplasm ovarian cancer skin basal cell carcinoma vitiligo Hashimoto thyroiditis large cell medulloblastoma medulloblastoma dermatomyositis Hodgkins lymphoma lung cancer myositis rheumatoid arthritis systemic sclerosis diabetes mellitus hypothyroidism malignant colon neoplasm ovarian cancer skin basal cell carcinoma vitiligo Hashimoto thyroiditis large cell medulloblastoma medulloblastoma psoriasis systemic lupus erythematosus

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.