Annotations: 9AVE

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14852	Fis1 N-terminal tetratricopeptide repeat (Fis1_TPR_N)	Fis1 N-terminal tetratricopeptide repeat	-	Repeat
A	PF14853	Fis1 C-terminal tetratricopeptide repeat (Fis1_TPR_C)	Fis1 C-terminal tetratricopeptide repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Mitochondrial fission 1 protein	binding lipid binding molecular adaptor activity identical protein binding protein binding	protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion cellular process establishment of protein localization to mitochondrion protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion cellular process establishment of protein localization to mitochondrion cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway intracellular signal transduction cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction signal transduction intrinsic apoptotic signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of programmed cell death regulation of apoptotic process biological regulation positive regulation of intracellular signal transduction cell death positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling regulation of localization transport negative regulation of biological process regulation of lipid transport negative regulation of transport negative regulation of lipid localization monocarboxylic acid transport fatty acid transport organic anion transport negative regulation of lipid transport carboxylic acid transport negative regulation of fatty acid transport regulation of transport lipid localization lipid transport regulation of fatty acid transport organic acid transport regulation of lipid localization negative regulation of organic acid transport regulation of organic acid transport cellular component organization organelle organization cellular component organization or biogenesis mitochondrion organization peroxisome organization peroxisome fission organelle fission mitochondrial fission ribose phosphate metabolic process ATP metabolic process negative regulation of small molecule metabolic process negative regulation of purine nucleotide metabolic process carbohydrate derivative metabolic process negative regulation of phosphate metabolic process negative regulation of ATP metabolic process regulation of primary metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process negative regulation of nucleotide metabolic process ribonucleotide metabolic process regulation of small molecule metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process regulation of phosphate metabolic process regulation of nucleotide metabolic process phosphate-containing compound metabolic process negative regulation of cellular process small molecule metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process purine nucleoside triphosphate metabolic process negative regulation of metabolic process primary metabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process purine-containing compound metabolic process organophosphate metabolic process negative regulation of phosphorus metabolic process metabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process regulation of metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane peroxisome microbody cytosol mitochondrial membrane organelle outer membrane membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane peroxisome microbody cytosol mitochondrial membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane microbody membrane peroxisomal membrane protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR033745	Mitochondria fission protein Fis1, cytosolic domain	Domain
A	IPR016543	Mitochondria fission 1 protein	Family
A	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A	IPR028058	Fis1, N-terminal tetratricopeptide repeat	Repeat
A	IPR028061	Fis1, C-terminal tetratricopeptide repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9Y3D6	Ceroid lipofuscinosis, neuronal 1, infantile attention deficit hyperactivity disorder, inattentive type lymphoplasmacytic lymphoma polycystic ovary syndrome ovarian cancer large cell medulloblastoma plasma cell myeloma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.