8ZTF | pdb_00008ztf

Structure of calcium preference ATP-gated channel P2X1 in the Pre-open state in the presence of 10mM Calcium ion

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	P2X purinoceptor 1	monoatomic cation transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity extracellularly ATP-gated monoatomic cation channel activity gated channel activity ATP-gated ion channel activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity extracellularly ATP-gated monoatomic cation channel activity gated channel activity ATP-gated ion channel activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic cation channel activity calcium channel activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity ligand-gated calcium channel activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity purinergic nucleotide receptor activity nucleotide receptor activity protein-containing complex binding amide binding organic acid binding suramin binding sulfur compound binding identical protein binding protein binding	regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport biological regulation positive regulation of biological process establishment of localization localization positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport multicellular organismal process system process regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport biological regulation positive regulation of biological process establishment of localization localization positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport multicellular organismal process system process circulatory system process regulation of blood pressure regulation of biological quality blood circulation regulation of calcium ion transport metal ion transport calcium ion transport regulation of metal ion transport monoatomic cation transport ceramide metabolic process membrane lipid metabolic process sphingolipid biosynthetic process lipid biosynthetic process amide biosynthetic process sphingolipid metabolic process primary metabolic process biosynthetic process ceramide biosynthetic process metabolic process cellular process amide metabolic process membrane lipid biosynthetic process lipid metabolic process apoptotic process cell death programmed cell death regulation of tube diameter regulation of tube size regulation of system process regulation of blood circulation regulation of vasoconstriction vascular process in circulatory system regulation of multicellular organismal process blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size monoamine transport regulated exocytosis cellular localization nitrogen compound transport response to stimulus serotonin secretion involved in inflammatory response signaling organic hydroxy compound transport vesicle-mediated transport cell communication secretion by cell serotonin secretion by platelet signal release response to stress establishment of localization in cell serotonin secretion serotonin production involved in inflammatory response production of molecular mediator involved in inflammatory response secretion defense response platelet degranulation export from cell cell-cell signaling serotonin transport exocytosis exocytic process inflammatory response muscle contraction muscle system process regulation of muscle system process smooth muscle contraction regulation of smooth muscle contraction regulation of muscle contraction nervous system process action potential transmission of nerve impulse neuronal action potential regulation of membrane potential regulation of body fluid levels wound healing cell activation hemostasis blood coagulation coagulation response to wounding platelet activation positive regulation of cation transmembrane transport positive regulation of calcium ion transport regulation of cellular process positive regulation of calcium ion import positive regulation of monoatomic ion transmembrane transport calcium ion import into cytosol regulation of calcium ion import import across plasma membrane inorganic ion transmembrane transport inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport calcium ion import across plasma membrane regulation of calcium ion import across plasma membrane import into cell monoatomic ion transmembrane transport regulation of monoatomic ion transmembrane transport regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport positive regulation of calcium ion import across plasma membrane positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport positive regulation of cellular process calcium ion transmembrane import into cytosol inorganic cation import across plasma membrane inorganic ion import across plasma membrane regulation of monoatomic cation transmembrane transport calcium ion import calcium ion transmembrane transport response to chemical response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to ATP response to purine-containing compound inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis regulation of cytosolic calcium ion concentration regulation of presynaptic cytosolic calcium ion concentration cellular homeostasis neuron cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis vascular associated smooth muscle contraction regulation of vascular associated smooth muscle contraction behavior multi-multicellular organism process reproductive process multicellular organismal reproductive process reproductive behavior insemination mating behavior multi-organism reproductive process copulation modulation of chemical synaptic transmission synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport in synapse regulation of regulated secretory pathway synaptic signaling regulation of secretion by cell trans-synaptic signaling regulation of signaling neurotransmitter secretion regulation of neurotransmitter transport regulation of synaptic vesicle exocytosis neurotransmitter transport regulation of vesicle-mediated transport regulation of secretion chemical synaptic transmission signal release from synapse regulation of trans-synaptic signaling regulation of neurotransmitter secretion anterograde trans-synaptic signaling regulation of exocytosis regulation of cell communication synaptic transmission, glutamatergic	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane cell surface external side of plasma membrane side of membrane membrane microdomain cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane cell surface external side of plasma membrane side of membrane membrane microdomain membrane raft protein-containing complex glutamatergic synapse presynaptic active zone membrane presynaptic membrane presynapse presynaptic active zone

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR053792	ATP P2X receptor, conserved site	Conserved Site
A, B, C	IPR001429	P2X purinoreceptor	Family
A, B, C	IPR027309	P2X purinoreceptor extracellular domain superfamily	Homologous Superfamily
A, B, C	IPR003044	P2X1 purinoceptor	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.