8ZKR | pdb_00008zkr

Structure of Polycystin-1/Polycystin-2 complex with phosphatidic acid bound

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Polycystin-1	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity Wnt receptor activity molecular function inhibitor activity transcription regulator activity molecular function regulator activity transcription regulator inhibitor activity calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity Wnt receptor activity molecular function inhibitor activity transcription regulator activity molecular function regulator activity transcription regulator inhibitor activity calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity protein binding binding protein domain specific binding carbohydrate binding transmembrane transporter binding kinase binding enzyme binding protein kinase binding	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development mesonephric epithelium development epithelium development kidney epithelium development mesonephros development developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development mesonephric epithelium development epithelium development kidney epithelium development mesonephros development tube development renal system development kidney development mesonephric tubule development regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process heart development circulatory system development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue morphogenesis anatomical structure morphogenesis tube morphogenesis morphogenesis of a branching structure epithelial tube morphogenesis morphogenesis of a branching epithelium protein localization cellular localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein export from nucleus establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization nuclear export intracellular protein transport nephric duct development mesonephric duct development establishment of cell polarity establishment or maintenance of cell polarity calcium-independent cell-matrix adhesion cell-matrix adhesion cell-substrate adhesion placenta blood vessel development placenta development vasculature development blood vessel development cell aggregation cartilage condensation skeletal system morphogenesis animal organ morphogenesis embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development metanephros development collecting duct development metanephric collecting duct development monoatomic ion transmembrane transport inorganic ion transmembrane transport calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport calcium ion transmembrane transport cellular response to stimulus cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway response to stimulus signaling cell communication signal transduction cell surface receptor signaling pathway via JAK-STAT nitrogen cycle metabolic process metabolic process protein phosphorylation phosphorylation primary metabolic process peptidyl-serine modification peptidyl-serine phosphorylation macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules nephron tubule development metanephric epithelium development loop of Henle development metanephric loop of Henle development renal tubule development nephron development metanephric nephron epithelium development nephron epithelium development metanephric ascending thin limb development metanephric nephron tubule development ascending thin limb development metanephric tubule development nephron morphogenesis metanephric tubule morphogenesis nephron tubule morphogenesis nephron epithelium morphogenesis metanephric distal tubule development distal tubule morphogenesis metanephros morphogenesis metanephric nephron tubule morphogenesis metanephric nephron development metanephric nephron morphogenesis kidney morphogenesis metanephric distal tubule morphogenesis distal tubule development renal tubule morphogenesis catabolic process proteolysis involved in protein catabolic process macromolecule catabolic process regulation of primary metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis proteolysis regulation of protein metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process regulation of proteasomal protein catabolic process regulation of metabolic process regulation of protein catabolic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription response to stress response to fluid shear stress hepaticobiliary system development gland development liver development positive regulation of cytosolic calcium ion concentration regulation of biological quality protein-containing complex organization protein heterotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly cellular component organization or biogenesis protein heterooligomerization spinal cord development central nervous system development nervous system development respiratory tube development lung epithelium development lung development respiratory system development skin development establishment of organelle localization mitochondrion distribution mitocytosis establishment of mitochondrion localization export from cell mitochondrion localization organelle localization migracytosis detection of external stimulus detection of stimulus detection of mechanical stimulus response to mechanical stimulus response to external stimulus response to abiotic stimulus detection of abiotic stimulus digestive system development digestive tract development metanephric proximal tubule development proximal tubule development embryonic placenta development embryonic organ development regulation of cytoskeleton organization regulation of cellular component organization microtubule cytoskeleton organization regulation of mitotic spindle organization mitotic cell cycle cell cycle regulation of cell cycle microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process regulation of cell cycle process regulation of microtubule-based process regulation of spindle organization regulation of organelle organization mitotic spindle organization organelle organization mitotic cell cycle process microtubule-based process cytoskeleton organization regulation of microtubule cytoskeleton organization lymph vessel morphogenesis lymph vessel development Wnt signaling pathway neural tube development regulation of cell cycle phase transition cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition genitalia development reproductive system development reproductive process sex differentiation developmental process involved in reproduction reproductive structure development	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery basal part of cell plasma membrane cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery basal part of cell plasma membrane basal plasma membrane plasma membrane region basolateral plasma membrane intracellular anatomical structure cytoplasm protein-containing complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex intracellular organelle Golgi apparatus intracellular membrane-bounded organelle endomembrane system Golgi membrane bounding membrane of organelle organelle membrane polycystin complex cell projection cilium plasma membrane bounded cell projection intracellular vesicle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle Golgi-associated vesicle membrane Golgi-associated vesicle cell surface motile cilium ciliary membrane cell projection membrane migrasome lateral plasma membrane nucleus endoplasmic reticulum
B, C, D	Polycystin-2	cytoskeletal protein binding protein binding binding alpha-actinin binding actinin binding muscle alpha-actinin binding monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity cytoskeletal protein binding protein binding binding alpha-actinin binding actinin binding muscle alpha-actinin binding monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity cation binding ion binding calcium ion binding metal ion binding small molecule binding signaling receptor binding voltage-gated sodium channel activity sodium channel activity sodium ion transmembrane transporter activity identical protein binding protein homodimerization activity protein dimerization activity calcium-induced calcium release activity calcium channel activity intracellularly ligand-gated monoatomic ion channel activity intracellularly gated calcium channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity calcium ion transmembrane transporter activity ligand-gated calcium channel activity ligand-gated monoatomic cation channel activity outward rectifier potassium channel activity molecular function inhibitor activity transcription regulator activity molecular function regulator activity transcription regulator inhibitor activity phosphoprotein binding HLH domain binding protein domain specific binding ATPase binding enzyme binding voltage-gated calcium channel activity transmembrane transporter binding	multicellular organismal process kidney epithelium development metanephric epithelium development nephron tubule development metanephric distal tubule development renal system development multicellular organism development metanephros development anatomical structure development renal tubule development nephron development metanephric nephron epithelium development nephron epithelium development system development multicellular organismal process kidney epithelium development metanephric epithelium development nephron tubule development metanephric distal tubule development renal system development multicellular organism development metanephros development anatomical structure development renal tubule development nephron development metanephric nephron epithelium development nephron epithelium development system development developmental process epithelium development tube development metanephric nephron tubule development animal organ development tissue development distal tubule development metanephric tubule development kidney development regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process positive regulation of cellular process mesonephric epithelium development mesonephros development mesonephric tubule development heart development circulatory system development transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport monoatomic cation transport microtubule organizing center organization microtubule cytoskeleton organization cellular component organization centrosome duplication organelle organization centrosome cycle microtubule-based process cell cycle cellular component organization or biogenesis cytoskeleton organization cell cycle process regulation of calcium ion transmembrane transporter activity positive regulation of cell communication cellular response to stimulus regulation of localization regulation of calcium ion transport positive regulation of cation transmembrane transport positive regulation of calcium ion transport positive regulation of signal transduction intracellular calcium ion homeostasis response to stimulus negative regulation of biological process regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity regulation of signal transduction calcium ion transport cell communication positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport signal transduction monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport regulation of cation channel activity positive regulation of cation channel activity maintenance of location regulation of molecular function release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis regulation of response to stimulus cellular localization inorganic ion homeostasis homeostatic process signaling regulation of transmembrane transporter activity calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion regulation of transporter activity maintenance of location in cell regulation of calcium ion transmembrane transport positive regulation of response to stimulus positive regulation of molecular function positive regulation of calcium ion transmembrane transporter activity intracellular monoatomic cation homeostasis positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport monoatomic ion homeostasis negative regulation of cellular process intracellular chemical homeostasis positive regulation of release of sequestered calcium ion into cytosol regulation of metal ion transport regulation of sequestering of calcium ion regulation of monoatomic ion transmembrane transporter activity regulation of signaling calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity cellular homeostasis positive regulation of transport positive regulation of transporter activity positive regulation of ion transmembrane transporter activity regulation of cell communication regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport positive regulation of signaling cellular response to metal ion cellular response to chemical stimulus response to metal ion response to chemical cellular response to calcium ion response to calcium ion cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway cell surface receptor signaling pathway via JAK-STAT cellular response to stress response to stress response to fluid shear stress cellular response to fluid shear stress response to osmotic stress cellular response to chemical stress cellular response to osmotic stress cellular response to environmental stimulus response to abiotic stimulus cellular response to abiotic stimulus spinal cord development central nervous system development nervous system development gland development pattern specification process liver development regionalization determination of liver left/right asymmetry hepaticobiliary system development determination of bilateral symmetry determination of left/right symmetry left/right pattern formation specification of symmetry detection of external stimulus detection of stimulus detection of mechanical stimulus response to mechanical stimulus response to external stimulus detection of abiotic stimulus placenta development chordate embryonic development embryo development in utero embryonic development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development renal cortex development mesenchyme development metanephric cortex development cellular response to acid chemical response to oxygen-containing compound response to water cellular response to oxygen-containing compound response to acid chemical cellular response to hydrostatic pressure cellular response to water stimulus response to hydrostatic pressure establishment of localization in cell sodium ion transmembrane transport sodium ion transport cell population proliferation regulation of cell population proliferation Wnt signaling pathway metanephric mesenchyme development kidney mesenchyme development nephron morphogenesis metanephric nephron morphogenesis S-shaped body morphogenesis metanephric S-shaped body morphogenesis kidney morphogenesis anatomical structure morphogenesis metanephros morphogenesis animal organ morphogenesis metanephric nephron development response to endogenous stimulus detection of nodal flow cellular response to endogenous stimulus renal artery morphogenesis blood vessel morphogenesis artery development vasculature development kidney vasculature development tube morphogenesis renal system vasculature development artery morphogenesis kidney vasculature morphogenesis blood vessel development renal system vasculature morphogenesis regulation of calcium ion import calcium ion import cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein tetramerization protein-containing complex assembly smooth muscle tissue development metanephric smooth muscle tissue development muscle tissue development kidney smooth muscle tissue development regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process macromolecule metabolic process nephric duct development mesonephric duct development aorta development placenta blood vessel development loop of Henle development metanephric loop of Henle development metanephric ascending thin limb development ascending thin limb development branching morphogenesis of an epithelial tube nephron tubule morphogenesis nephron epithelium morphogenesis ureteric bud morphogenesis branching involved in ureteric bud morphogenesis epithelial tube morphogenesis ureteric bud development morphogenesis of an epithelium tissue morphogenesis morphogenesis of a branching structure mesonephric tubule morphogenesis renal tubule morphogenesis morphogenesis of a branching epithelium positive regulation of DNA-templated transcription RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription heart morphogenesis embryonic heart tube development embryonic heart tube morphogenesis heart looping embryonic organ morphogenesis embryonic morphogenesis determination of heart left/right asymmetry positive regulation of cytosolic calcium ion concentration regulation of biological quality protein heterotetramerization protein heterooligomerization protein homotetramerization protein homooligomerization cellular response to nitrogen compound response to organophosphorus response to nitrogen compound response to purine-containing compound response to cAMP cellular response to cAMP cortical collecting duct development metanephric cortical collecting duct development cellular response to oxidative stress response to reactive oxygen species cellular response to reactive oxygen species response to oxidative stress negative regulation of cell population proliferation regulation of cell cycle phase transition negative regulation of cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cell cycle phase transition regulation of cell cycle negative regulation of G1/S transition of mitotic cell cycle negative regulation of mitotic cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition negative regulation of cell cycle process regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition plasma membrane bounded cell projection organization cell projection organization cilium organization metanephric part of ureteric bud development neural tube development	cell-cell junction cellular anatomical structure anchoring junction cell junction intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle organelle subcompartment cytoplasmic side of membrane membrane intracellular membrane-bounded organelle endomembrane system side of membrane cell-cell junction cellular anatomical structure anchoring junction cell junction intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle organelle subcompartment cytoplasmic side of membrane membrane intracellular membrane-bounded organelle endomembrane system side of membrane endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasmic side of endoplasmic reticulum membrane organelle membrane endoplasmic reticulum membrane intracellular membraneless organelle cilium plasma membrane bounded cell projection ciliary basal body cell projection microtubule organizing center cytoskeleton membraneless organelle microtubule cytoskeleton cell periphery basal part of cell plasma membrane basal plasma membrane plasma membrane region motile cilium non-motile cilium ciliary membrane bounding membrane of organelle cell projection membrane migrasome intracellular vesicle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle lumenal side of endoplasmic reticulum membrane lumenal side of membrane cell leading edge lamellipodium extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle basolateral plasma membrane Golgi apparatus protein-containing complex polycystin complex cell cortex cell cortex region cytoplasmic region basal cortex mitotic spindle spindle transmembrane transporter complex membrane protein complex cation channel complex transporter complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR042060	Polycystin-1 like, PLAT/LH2 domain	Domain
A	IPR016187	C-type lectin fold	Homologous Superfamily
A	IPR035986	PKD domain superfamily	Homologous Superfamily
A	IPR001611	Leucine-rich repeat	Repeat
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR000483	Cysteine-rich flanking region, C-terminal	Domain
A	IPR000372	Leucine-rich repeat N-terminal domain	Domain
A	IPR022409	PKD/Chitinase domain	Domain
A	IPR000601	PKD domain	Domain
A	IPR046791	Polycystin domain	Domain
A	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A	IPR000434	Polycystic kidney disease type 1 protein	Family
A	IPR001024	PLAT/LH2 domain	Domain
A	IPR001304	C-type lectin-like	Domain
A	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A	IPR000203	GPS motif	Conserved Site
A	IPR006228	Polycystin cation channel	Domain
A	IPR002859	PKD/REJ-like domain	Domain
A	IPR036392	PLAT/LH2 domain superfamily	Homologous Superfamily
A	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A	IPR002889	Carbohydrate-binding WSC	Domain
A	IPR013122	Polycystin cation channel, PKD1/PKD2	Domain
A	IPR014010	REJ domain	Domain
B, C, D	IPR002048	EF-hand domain	Domain
B, C, D	IPR003915	Polycystic kidney disease type 2 protein	Family
B, C, D	IPR051223	Polycystin	Family
B, C, D	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily
B, C, D	IPR013122	Polycystin cation channel, PKD1/PKD2	Domain
B, C, D	IPR046791	Polycystin domain	Domain
B, C, D	IPR011992	EF-hand domain pair	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P98161	autosomal dominant polycystic kidney disease polycystic kidney disease 1 Polycystic Kidney, Autosomal Dominant thoracic aortic aneurysm atrial fibrillation cerebrovascular disorder dilated cardiomyopathy metabolic syndrome X polycystic kidney disease 2 Pick disease polycystic kidney disease autosomal dominant polycystic kidney disease type 1 with tuberous sclerosis kidney disease pituitary cancer
B, C, D	Pharos: Q13563	polycystic kidney disease 2 retinal disease autosomal dominant polycystic kidney disease Liver Cirrhosis, Experimental vascular disease ovarian cancer Pick disease cerebrovascular disorder Ehlers-Danlos syndrome neurodegenerative disease pancreatic intraductal papillary-mucinous carcinoma polycystic kidney disease thoracic aortic aneurysm breast cancer Emery-Dreifuss muscular dystrophy polycystic kidney disease 2 retinal disease autosomal dominant polycystic kidney disease Liver Cirrhosis, Experimental vascular disease ovarian cancer Pick disease cerebrovascular disorder Ehlers-Danlos syndrome neurodegenerative disease pancreatic intraductal papillary-mucinous carcinoma polycystic kidney disease thoracic aortic aneurysm breast cancer Emery-Dreifuss muscular dystrophy invasive ductal breast carcinoma malignant mesothelioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia progressive supranuclear palsy breast carcinoma gout kidney disease nephrolithiasis