Annotations: 8GTX

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Tudor/PWWP/MBT domain-like	8052901	3000404	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Tudor/PWWP/MBT domain-like	8052902	3000404	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Tudor/PWWP/MBT domain-like	8052900	3000404	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02513	Spin/Ssty Family (Spin-Ssty)	Spin/Ssty Family	Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo [1]. The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis and forms part of this Pfam family. Members of this f ...	Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo [1]. The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis and forms part of this Pfam family. Members of this family contain three copies of this 50 residue repeat. The repeat is predicted to contain four beta strands.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Spindlin-1	histone reader activity chromatin-protein adaptor activity protein-macromolecule adaptor activity molecular adaptor activity	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway positive regulation of cellular process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway biological regulation regulation of response to stimulus regulation of cell communication cellular process positive regulation of signaling RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process sexual reproduction reproductive process multicellular organismal reproductive process gamete generation rRNA transcription rRNA metabolic process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process protein localization localization protein localization to chromatin cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization meiotic cell cycle cell cycle negative regulation of biological process cellular component organization chromatin organization negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process retrotransposition heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process transposable element silencing by heterochromatin formation transposition regulatory ncRNA-mediated gene silencing negative regulation of gene expression constitutive heterochromatin formation regulatory ncRNA-mediated heterochromatin formation negative regulation of biosynthetic process transposable element silencing by piRNA-mediated DNA methylation negative regulation of macromolecule biosynthetic process DNA methylation-dependent constitutive heterochromatin formation transposable element silencing negative regulation of gene expression, epigenetic gene silencing by piRNA-directed DNA methylation piRNA-mediated heterochromatin formation	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen nuclear membrane membrane endomembrane system organelle envelope nuclear envelope organelle membrane cytoplasm cytosol cytoskeleton spindle microtubule cytoskeleton nucleoplasm chromatin chromosome
B	HBx	-	symbiont-mediated perturbation of host NF-kappaB cascade symbiont-mediated activation of host NF-kappaB cascade symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated activation of host signal transduction pathway symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host cell cycle progression symbiont-mediated arrest of host cell cycle during G2/M transition RNA metabolic process primary metabolic process symbiont-mediated perturbation of host NF-kappaB cascade symbiont-mediated activation of host NF-kappaB cascade symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated activation of host signal transduction pathway symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host cell cycle progression symbiont-mediated arrest of host cell cycle during G2/M transition RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process viral genome replication viral process viral life cycle	host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical structure host cell part host intracellular region host cell nucleus host intracellular organelle host cell cytoplasm host cell mitochondrion host cell cytoplasm part

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR042567	Spindlin/spermiogenesis-specific domain superfamily	Homologous Superfamily
A	IPR003671	Spindlin/spermiogenesis-specific protein	Family
B	IPR000236	Transactivation protein X	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9Y657	acute myeloid leukemia cystic fibrosis glioblastoma malignant ependymoma myopathy pancreatic ductal adenocarcinoma amyotrophic lateral sclerosis Duchenne muscular dystrophy juvenile dermatomyositis malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm Becker muscular dystrophy Emery-Dreifuss muscular dystrophy limb-girdle muscular dystrophy acute myeloid leukemia cystic fibrosis glioblastoma malignant ependymoma myopathy pancreatic ductal adenocarcinoma amyotrophic lateral sclerosis Duchenne muscular dystrophy juvenile dermatomyositis malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm Becker muscular dystrophy Emery-Dreifuss muscular dystrophy limb-girdle muscular dystrophy medulloblastoma ovarian cancer sinusitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.