8AFA | pdb_00008afa

Cryo-EM structure of a substrate-bound glutamate transporter homologue GltTk encapsulated within a nanodisc

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Proton glutamate symport protein	8065925	3001772	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Proton glutamate symport protein	8065925	3001772	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Proton glutamate symport protein	8065925	3001772	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e8afaA1	A: alpha complex topology	X: Proton glutamate symport protein (From Topology)	H: Proton glutamate symport protein (From Topology)	T: Proton glutamate symport protein	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e8afaB1	A: alpha complex topology	X: Proton glutamate symport protein (From Topology)	H: Proton glutamate symport protein (From Topology)	T: Proton glutamate symport protein	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e8afaC1	A: alpha complex topology	X: Proton glutamate symport protein (From Topology)	H: Proton glutamate symport protein (From Topology)	T: Proton glutamate symport protein	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.3860.10	Mainly Alpha	Orthogonal Bundle	Proton glutamate symport protein	Sodium:dicarboxylate symporter	CATH (utative)
B	1.10.3860.10	Mainly Alpha	Orthogonal Bundle	Proton glutamate symport protein	Sodium:dicarboxylate symporter	CATH (utative)
C	1.10.3860.10	Mainly Alpha	Orthogonal Bundle	Proton glutamate symport protein	Sodium:dicarboxylate symporter	CATH (utative)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Proton/glutamate symporter, SDF family	active transmembrane transporter activity transporter activity symporter activity transmembrane transporter activity secondary active transmembrane transporter activity	organic acid transport localization organic anion transport carboxylic acid transport transport establishment of localization	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR001991	Sodium:dicarboxylate symporter	Family
A, B, C	IPR036458	Sodium:dicarboxylate symporter superfamily	Homologous Superfamily
A, B, C	IPR018107	Sodium:dicarboxylate symporter, conserved site	Conserved Site

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C	OPM	Transmembrane	Alpha-helical polytopic	Dicarboxylate/amino acid:Cation Symporter (DAACS)	Proton glutamate symport protein

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Amino Acid Secondary Transporters	Glutamate Transporter Homologue (Glt_Tk), P208R mutant, with bound L-aspartate

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.