5IJO | pdb_00005ijo

Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Nucleoporin beta-propeller domain	8090969	3000456	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Nucleoporin beta-propeller domain	8090969	3000456	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Nucleoporin beta-propeller domain	8090969	3000456	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Nucleoporin beta-propeller domain	8090969	3000456	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Nucleoporin beta-propeller domain	8090969	3000456	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	Nucleoporin beta-propeller domain	8090969	3000456	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Scaffolding nucleoporins	8090313	3002255	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Scaffolding nucleoporins	8090313	3002255	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Scaffolding nucleoporins	8090313	3002255	SCOP2B (2022-06-29)
U	SCOP2B Superfamily	Scaffolding nucleoporins	8090313	3002255	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Nup58-like	8053256	3002169	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Nup58-like	8053256	3002169	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	Nup58-like	8053256	3002169	SCOP2B (2022-06-29)
Y	SCOP2B Superfamily	Nup58-like	8053256	3002169	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Nup62-like	8053268	3002170	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Nup62-like	8053268	3002170	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	Nup62-like	8053268	3002170	SCOP2B (2022-06-29)
Z	SCOP2B Superfamily	Nup62-like	8053268	3002170	SCOP2B (2022-06-29)
V	SCOP2B Superfamily	Scaffolding nucleoporins	8053964	3002255	SCOP2B (2022-06-29)
J	SCOP2 Family	Nup188-like	8044976	4004233	SCOP2 (2022-06-29)
J	SCOP2 Superfamily	Scaffolding nucleoporins	8053964	3002255	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Nucleoporin_N	e5ijoB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Nucleoporin_N	ECOD (1.6)
B	Nucleoporin_C_N	e5ijoB2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_N	ECOD (1.6)
K	Nucleoporin_N	e5ijoK1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Nucleoporin_N	ECOD (1.6)
K	Nucleoporin_C_C	e5ijoK2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_C	ECOD (1.6)
K	Nucleoporin_C_N	e5ijoK3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_N	ECOD (1.6)
A	Nucleoporin_N	e5ijoA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Nucleoporin_N	ECOD (1.6)
A	Nucleoporin_C_N	e5ijoA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_N	ECOD (1.6)
E	Nucleoporin_N	e5ijoE1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Nucleoporin_N	ECOD (1.6)
E	Nucleoporin_C_C	e5ijoE2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_C	ECOD (1.6)
E	Nucleoporin_C_N	e5ijoE3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_N	ECOD (1.6)
Q	Nucleoporin_N	e5ijoQ1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Nucleoporin_N	ECOD (1.6)
Q	Nucleoporin_C_C	e5ijoQ2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_C	ECOD (1.6)
Q	Nucleoporin_C_N	e5ijoQ3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_N	ECOD (1.6)
W	Nucleoporin_N	e5ijoW1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Nucleoporin_N	ECOD (1.6)
W	Nucleoporin_C_C	e5ijoW2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_C	ECOD (1.6)
W	Nucleoporin_C_N	e5ijoW3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_N	ECOD (1.6)
I	Nic96	e5ijoI1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Nic96	ECOD (1.6)
C	Nic96	e5ijoC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Nic96	ECOD (1.6)
O	Nic96	e5ijoO1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Nic96	ECOD (1.6)
U	Nic96	e5ijoU1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Nic96	ECOD (1.6)
P	Nup192_1st	e5ijoP1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Nup192_1st	ECOD (1.6)
P	Nup192_2nd	e5ijoP2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Nup192_2nd	ECOD (1.6)
D	Nup192_1st	e5ijoD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Nup192_1st	ECOD (1.6)
D	Nup192_2nd	e5ijoD2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Nup192_2nd	ECOD (1.6)
V	Nup188	e5ijoV1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Nup188	ECOD (1.6)
J	Nup188	e5ijoJ1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Nup188	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, E, K, Q A, B, E, K, Q, W	PF03177	Non-repetitive/WGA-negative nucleoporin C-terminal (Nucleoporin_C)	Non-repetitive/WGA-negative nucleoporin C-terminal	-	Repeat
A, B, E, K, Q A, B, E, K, Q, W	PF08801	Nup133 N terminal like (Nucleoporin_N)	Nup133 N terminal like	-	Repeat
C, I, O, U	PF04097	Nup93/Nic96 (Nic96)	Nup93/Nic96	-	Repeat
D, P	PF11894	Nuclear pore complex scaffold, nucleoporins 186/192/205 (Nup192)	Nuclear pore complex scaffold, nucleoporins 186/192/205	-	Repeat
F, L, R, X	PF18437	Nup54 C-terminal interacting domain (Nup54_C)	Nup54 C-terminal interacting domain	The mammalian nuclear pore complex (NPC) conducts nucleocytoplasmic transport and contains multiple copies of nucleoporins (nups). This is the C-terminal interacting domain found on Nup54. Nup45 is a splice variant of Nup58 with an identical alpha-he ...	The mammalian nuclear pore complex (NPC) conducts nucleocytoplasmic transport and contains multiple copies of nucleoporins (nups). This is the C-terminal interacting domain found on Nup54. Nup45 is a splice variant of Nup58 with an identical alpha-helical region. Nup54 along with Nup62 and Nup58 are essential for nuclear transport. The C-terminal part of the alpha-helical region of Nup54 interacts with a C-terminal part of the alpha-helical region of Nup58. Interestingly, this region appears in two distinct conformations: a single helix and a helix-loop-helix, termed 'straight' and 'bent'. Whereas the straight conformer consists of a 34 residues long alpha helix (residues 460-493), the bent conformer is composed of two alpha helices, each 13 residues long, connected by a central loop (N helix, residues 460-472; C helix, residues 477-489) [1].	Domain
F, L, R, X	PF13874	Nucleoporin complex subunit 54 (Nup54)	Nucleoporin complex subunit 54	This is the human Nup54 subunit of the nucleoporin complex, equivalent to Nup57 of yeast. Nup54, Nup58 and Nup62 all have similar affinities for importin-beta. It seems likely that they are the only FG-repeat nucleoporins of the central channel, and ...	This is the human Nup54 subunit of the nucleoporin complex, equivalent to Nup57 of yeast. Nup54, Nup58 and Nup62 all have similar affinities for importin-beta. It seems likely that they are the only FG-repeat nucleoporins of the central channel, and as such they would form a zone of equal affinity spanning the central channel. The diffusion of importin-beta import complexes through the central channel may be a stochastic process as the affinities are similar, whereas movement from cytoplasmic fibrils to the central channel and from the central channel to the nuclear basket would be facilitated by the subtle differences in affinity between them [1,2].	Domain
J, V	PF10487	Nucleoporin Nup188, N-terminal (Nup188_N)	Nucleoporin Nup188, N-terminal	-	Repeat
J, V	PF21093	Nucleoporin Nup188, N-terminal subdomain III (Nup188_N-subdom_III)	Nucleoporin Nup188, N-terminal subdomain III	-	Repeat
J, V	PF21094	Nup188 SH3-like domain (Nup188_SH3-like)	Nup188 SH3-like domain	Nup188 is one of the many peptides that make up the nucleoporin complex (NPC), and is found across eukaryotes [1,2]. The Nup188 subcomplex (Nic96p-Nup188p-Nup192p-Pom152p) is one of at least six that make up the NPC, and as such is symmetrically loca ...	Nup188 is one of the many peptides that make up the nucleoporin complex (NPC), and is found across eukaryotes [1,2]. The Nup188 subcomplex (Nic96p-Nup188p-Nup192p-Pom152p) is one of at least six that make up the NPC, and as such is symmetrically localised on both faces of the NPC at the nuclear end, being integrally bound to the C terminus of Pom34p [3]. This protein folds into an extended stack of helices where the N-terminal forms a closed ring (subdivided into subdomains I-III in [2]) and the C-terminal forms a more regular, superhelical structure [2]. This entry represents a beta-stranded SH3-like domain inserted in subdomain III from Nup188 N-terminal region, which is a circular permutation from canonical SH3 domain [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, E, K, Q A, B, E, K, Q, W	Nuclear pore complex protein Nup155	structural molecule activity structural constituent of nuclear pore	membrane organization cellular component organization nucleus organization organelle organization nuclear envelope organization cellular process cellular component organization or biogenesis endomembrane system organization heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling membrane organization cellular component organization nucleus organization organelle organization nuclear envelope organization cellular process cellular component organization or biogenesis endomembrane system organization heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling regulation of heart contraction regulation of system process cell-cell signaling involved in cardiac conduction cardiac muscle contraction striated muscle contraction cell communication circulatory system process actin filament-based process regulation of multicellular organismal process regulation of biological quality atrial cardiac muscle cell to AV node cell communication cell communication involved in cardiac conduction blood circulation cardiac muscle cell contraction regulation of biological process atrial cardiac muscle cell action potential biological regulation cell-cell signaling action potential actin filament-based movement muscle contraction muscle system process regulation of blood circulation cardiac conduction actin-mediated cell contraction heart contraction cardiac muscle cell action potential regulation of membrane potential chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization metabolic process macromolecule metabolic process protein localization protein localization to nucleus localization within membrane protein localization to membrane protein localization to nuclear envelope protein localization to organelle cellular macromolecule localization protein localization to nuclear inner membrane establishment of protein localization import into nucleus establishment of protein localization to organelle protein transport protein import into nucleus intracellular protein transport regulation of cellular process negative regulation of biological process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of cellular process RNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process miRNA processing regulation of macromolecule biosynthetic process regulation of metabolic process	cellular anatomical structure membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane organelle membrane nuclear pore inner ring cellular anatomical structure membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane organelle membrane nuclear pore inner ring protein-containing complex nuclear protein-containing complex nuclear pore cytoplasm cytosol
C, I, O, U	Nuclear pore complex protein Nup93	structural molecule activity structural constituent of nuclear pore	cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization metabolic process macromolecule metabolic process membrane organization cellular component organization nucleus organization organelle organization nuclear envelope organization cellular component organization or biogenesis endomembrane system organization nuclear pore organization protein-containing complex organization pore complex assembly cellular component biogenesis nuclear pore complex assembly cellular component assembly protein-containing complex assembly protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport	cellular anatomical structure membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane organelle membrane centrosome cellular anatomical structure membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane organelle membrane centrosome microtubule organizing center cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen protein-containing complex nuclear protein-containing complex nuclear pore
D, P	Nuclear pore complex protein Nup205	structural molecule activity structural constituent of nuclear pore	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport protein localization establishment of protein localization cellular localization protein transport cellular macromolecule localization nucleocytoplasmic transport nuclear transport establishment of localization in cell intracellular transport pore complex assembly cellular component biogenesis nuclear pore complex assembly cellular component assembly protein-containing complex assembly	cellular anatomical structure membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane organelle membrane nuclear pore inner ring cellular anatomical structure membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane organelle membrane nuclear pore inner ring protein-containing complex nuclear protein-containing complex nuclear pore cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen
F, L, R, X	Nucleoporin p54	protein-containing complex binding binding structural molecule activity structural constituent of nuclear pore identical protein binding protein binding	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process nucleocytoplasmic transport cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process nucleocytoplasmic transport regulation of protein localization transport nuclear transport regulation of protein localization to nucleus localization import into nucleus regulation of protein import into nucleus cellular macromolecule localization establishment of localization in cell protein import into nucleus regulation of intracellular transport regulation of biological process regulation of transport biological regulation regulation of establishment of protein localization intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of localization establishment of protein localization to organelle protein transport regulation of cellular localization macromolecule localization protein localization to organelle regulation of intracellular protein transport intracellular protein transport NLS-bearing protein import into nucleus RNA transport nucleic acid transport mRNA transport establishment of RNA localization RNA localization nucleobase-containing compound transport protein targeting localization within membrane protein localization to membrane protein localization to nuclear envelope protein localization to nuclear inner membrane	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel
G, M, S, Y	Nucleoporin p58/p45	protein-containing complex binding binding structural molecule activity structural constituent of nuclear pore identical protein binding protein binding nuclear localization sequence binding signal sequence binding peptide binding	localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular process establishment of localization protein localization regulation of localization establishment of protein localization nitrogen compound transport regulation of cellular process localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular process establishment of localization protein localization regulation of localization establishment of protein localization nitrogen compound transport regulation of cellular process regulation of protein localization regulation of protein localization to nucleus import into nucleus regulation of protein import into nucleus cellular macromolecule localization protein import into nucleus regulation of intracellular transport regulation of biological process regulation of transport biological regulation regulation of establishment of protein localization regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of protein localization to organelle protein transport regulation of cellular localization macromolecule localization protein localization to organelle regulation of intracellular protein transport intracellular protein transport RNA transport nucleic acid transport mRNA transport establishment of RNA localization RNA localization nucleobase-containing compound transport	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane
H, N, T, Z	Nuclear pore glycoprotein p62	Hsp90 protein binding protein binding binding heat shock protein binding SH2 domain binding protein domain specific binding chromatin binding PTB domain binding Hsp70 protein binding protein-folding chaperone binding ubiquitin binding ubiquitin-like protein binding phospholipid binding lipid binding Hsp90 protein binding protein binding binding heat shock protein binding SH2 domain binding protein domain specific binding chromatin binding PTB domain binding Hsp70 protein binding protein-folding chaperone binding ubiquitin binding ubiquitin-like protein binding phospholipid binding lipid binding structural molecule activity structural constituent of nuclear pore signaling receptor complex adaptor activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction cellular process positive regulation of signaling RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death cellular localization nucleocytoplasmic transport nuclear transport establishment of localization in cell intracellular transport establishment of organelle localization mitotic metaphase chromosome alignment mitotic cell cycle metaphase chromosome alignment cellular component organization chromosome localization organelle localization mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation cell cycle process mitotic nuclear division organelle fission chromosome organization sister chromatid segregation organelle organization nuclear division mitotic cell cycle process nuclear chromosome segregation establishment of chromosome localization negative regulation of signaling negative regulation of ERBB signaling pathway cell surface receptor protein tyrosine kinase signaling pathway negative regulation of cell communication regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway regulation of ERBB signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of epidermal growth factor receptor signaling pathway ERBB signaling pathway positive regulation of cell division cytoskeleton-dependent cytokinesis regulation of mitotic cytokinetic process positive regulation of mitotic cytokinesis mitotic cytokinetic process mitotic cytokinesis regulation of cell division regulation of mitotic cytokinesis positive regulation of cytokinesis positive regulation of mitotic cytokinetic process positive regulation of cell cycle process regulation of cell cycle regulation of cytokinesis regulation of cell cycle process cytokinesis regulation of cytokinetic process positive regulation of cell cycle cytokinetic process cell division small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction negative regulation of intracellular signal transduction regulation of Ras protein signal transduction Ras protein signal transduction negative regulation of small GTPase mediated signal transduction negative regulation of Ras protein signal transduction protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport positive regulation of ERBB signaling pathway positive regulation of epidermal growth factor receptor signaling pathway cellular response to stress response to stress cellular senescence positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division regulation of mitotic cell cycle positive regulation of nuclear division regulation of organelle organization regulation of nuclear division RNA export from nucleus nuclear export regulation of cytoskeleton organization microtubule cytoskeleton organization regulation of mitotic spindle organization microtubule cytoskeleton organization involved in mitosis spindle organization regulation of microtubule-based process regulation of spindle organization mitotic spindle organization microtubule-based process cytoskeleton organization regulation of microtubule cytoskeleton organization centriole assembly microtubule organizing center organization organelle assembly membraneless organelle assembly cellular component biogenesis cellular component assembly negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation centrosome cycle positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process centrosome duplication regulation of centriole replication centriole replication positive regulation of cellular component biogenesis regulation of centrosome cycle positive regulation of cytoskeleton organization regulation of cellular component biogenesis regulation of organelle assembly regulation of centrosome duplication positive regulation of centriole replication positive regulation of organelle assembly protein localization to microtubule cytoskeleton regulation of localization regulation of protein localization regulation of protein localization to centrosome protein localization to microtubule organizing center regulation of cellular localization protein localization to cytoskeleton positive regulation of protein localization positive regulation of protein localization to centrosome protein localization to centrosome centrosome separation mitotic centrosome separation	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane-bounded organelle organelle envelope nuclear envelope nucleus intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane-bounded organelle organelle envelope nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel centrosome microtubule organizing center cytoplasm mitotic spindle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen Flemming body midbody ribonucleoprotein complex
J, V	Nucleoporin NUP188 homolog	structural molecule activity structural constituent of nuclear pore	RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cellular localization nucleocytoplasmic transport nuclear transport RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cellular localization nucleocytoplasmic transport nuclear transport establishment of localization in cell intracellular transport cellular process protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport RNA export from nucleus nuclear export	cellular anatomical structure membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear pore inner ring protein-containing complex nuclear protein-containing complex cellular anatomical structure membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear pore inner ring protein-containing complex nuclear protein-containing complex nuclear pore cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, E, K, Q A, B, E, K, Q, W	IPR042537	Nucleoporin, Nup155-like, C-terminal, subdomain 2	Homologous Superfamily
A, B, E, K, Q A, B, E, K, Q, W	IPR042533	Nucleoporin, Nup155-like, C-terminal, subdomain 1	Homologous Superfamily
A, B, E, K, Q A, B, E, K, Q, W	IPR042538	Nucleoporin, Nup155-like, C-terminal, subdomain 3	Homologous Superfamily
A, B, E, K, Q A, B, E, K, Q, W	IPR014908	Nucleoporin, Nup133/Nup155-like, N-terminal	Domain
A, B, E, K, Q A, B, E, K, Q, W	IPR004870	Nucleoporin, Nup155-like	Family
A, B, E, K, Q A, B, E, K, Q, W	IPR007187	Nucleoporin, Nup133/Nup155-like, C-terminal	Domain
C, I, O, U	IPR007231	Nucleoporin interacting component Nup93/Nic96	Family
D, P	IPR021827	Nucleoporin Nup186/Nup192/Nup205	Family
F, L, R, X	IPR040985	Nup54, C-terminal interacting domain	Domain
F, L, R, X	IPR024864	Nucleoporin Nup54/Nup57/Nup44	Family
F, L, R, X	IPR025712	Nucleoporin Nup54, alpha-helical domain	Domain
G, M, S, Y	IPR024882	Nucleoporin p58/p45/NUP49	Family
H, N, T, Z	IPR007758	Nucleoporin, NSP1-like, C-terminal	Domain
H, N, T, Z	IPR026010	Nucleoporin NSP1/NUP62	Family
J, V	IPR016024	Armadillo-type fold	Homologous Superfamily
J, V	IPR044840	Nucleoporin Nup188	Family
J, V	IPR048883	Nucleoporin Nup188, N-terminal subdomain III	Domain
J, V	IPR018864	Nucleoporin Nup188, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, E, K, Q A, B, E, K, Q, W	Pharos: O75694	familial atrial fibrillation atrial fibrillation, familial, 15 adrenal cortex carcinoma large cell medulloblastoma malignant mesothelioma atrial fibrillation breast cancer lung cancer medulloblastoma atrial fibrillation, familial, 1 malignant colon neoplasm non-small cell lung carcinoma
C, I, O, U	Pharos: Q8N1F7	nephrotic syndrome, type 12 astrocytic tumor glioblastoma malignant ependymoma Nephrotic syndrome, idiopathic, steroid-resistant ovarian cancer primitive neuroectodermal tumor atypical teratoid rhabdoid tumor large cell medulloblastoma malignant glioma Pick disease Sjogren syndrome familial idiopathic steroid-resistant nephrotic syndrome lung cancer medulloblastoma nephrotic syndrome, type 12 astrocytic tumor glioblastoma malignant ependymoma Nephrotic syndrome, idiopathic, steroid-resistant ovarian cancer primitive neuroectodermal tumor atypical teratoid rhabdoid tumor large cell medulloblastoma malignant glioma Pick disease Sjogren syndrome familial idiopathic steroid-resistant nephrotic syndrome lung cancer medulloblastoma oligodendroglioma pilocytic astrocytoma
D, P	Pharos: Q92621	bone Paget disease nephrotic syndrome, type 13 astrocytic tumor familial idiopathic steroid-resistant nephrotic syndrome large cell medulloblastoma medulloblastoma non-small cell lung carcinoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor glioblastoma lung cancer Nephrotic syndrome, idiopathic, steroid-resistant pancreatic intraductal papillary-mucinous carcinoma invasive ductal breast carcinoma malignant glioma bone Paget disease nephrotic syndrome, type 13 astrocytic tumor familial idiopathic steroid-resistant nephrotic syndrome large cell medulloblastoma medulloblastoma non-small cell lung carcinoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor glioblastoma lung cancer Nephrotic syndrome, idiopathic, steroid-resistant pancreatic intraductal papillary-mucinous carcinoma invasive ductal breast carcinoma malignant glioma pancreatic intraductal papillary-mucinous neoplasm
F, L, R, X	Pharos: Q7Z3B4	lung cancer ovarian cancer malignant glioma plasma cell myeloma medulloblastoma
G, M, S, Y	Pharos: Q9BVL2	rheumatoid arthritis astrocytic tumor hepatocellular carcinoma malignant ependymoma nasopharyngeal carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma spina bifida atypical teratoid rhabdoid tumor large cell medulloblastoma malignant glioma non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia rheumatoid arthritis astrocytic tumor hepatocellular carcinoma malignant ependymoma nasopharyngeal carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma spina bifida atypical teratoid rhabdoid tumor large cell medulloblastoma malignant glioma non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor tuberculosis glioblastoma malignant colon neoplasm medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma Pick disease
H, N, T, Z	Pharos: P37198	familial infantile bilateral striatal necrosis astrocytic tumor infantile bilateral striatal necrosis lung cancer non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor intellectual disability malignant glioma osteosarcoma Striatonigral degeneration infantile large cell medulloblastoma medulloblastoma ovarian cancer
J, V	Pharos: Q5SRE5	cataract medulloblastoma osteosarcoma diabetes mellitus microcephaly intellectual disability microphthalmia