Annotations: 5G05

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	RING/U-box like	8082719	3000160	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	TPR-like	8057064	3001345	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	TPR-like	8057064	3001345	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Anaphase-promoting complex subunit 16-like	8053719	3002218	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	galactose-binding domain-like	8037020	3000087	SCOP2B (2022-06-29)
M	SCOP2 Family	Anaphase-promoting complex subunit 13	8047611	4005717	SCOP2 (2022-06-29)
M	SCOP2 Superfamily	Anaphase-promoting complex subunit 13	8093173	3002688	SCOP2 (2022-06-29)
G	SCOP2B Superfamily	CDC26-like	8053843	3002235	SCOP2B (2022-06-29)
R [auth W]	SCOP2B Superfamily	CDC26-like	8053843	3002235	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	WD40 repeat-like	8106386	3001694	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	WD40 repeat-like	8106386	3001694	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	zf-rbx1	e5g05B1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: zf-rbx1	ECOD (1.6)
C	KOG1155	e5g05C2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG1155	ECOD (1.6)
C	ANAPC8	e5g05C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ANAPC8	ECOD (1.6)
P	KOG1155	e5g05P3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG1155	ECOD (1.6)
P	ANAPC8	e5g05P2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ANAPC8	ECOD (1.6)
H	TPR_11_7	e5g05H1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_7	ECOD (1.6)
F	TPR_11_7	e5g05F1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_7	ECOD (1.6)
L	ANAPC10	e5g05L1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: ANAPC10	ECOD (1.6)
N	Cullin_4th	e5g05N3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Cullin_4th	ECOD (1.6)
N	Cullin_2nd	e5g05N4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Cullin_2nd	ECOD (1.6)
N	KOG2165	e5g05N2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG2165	ECOD (1.6)
N	Cullin_3rd	e5g05N1	A: a+b duplicates or obligate multimers	X: a+b domain in cullin-like proteins (From Topology)	H: a+b domain in cullin-like proteins (From Topology)	T: a+b domain in cullin-like proteins	F: Cullin_3rd	ECOD (1.6)
O	Apc5_N	e5g05O2	A: alpha arrays	X: SHQ1 C-terminal domain-like	H: Anaphase-promoting complex subunit 5 N-terminal domain (From Topology)	T: Anaphase-promoting complex subunit 5 N-terminal domain	F: Apc5_N	ECOD (1.6)
O	ANAPC5	e5g05O1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ANAPC5	ECOD (1.6)
A	KOG1858_3rd	e5g05A5	A: beta sandwiches	X: 26S proteasome subunit Rpn2 C-terminal domain (From Topology)	H: 26S proteasome subunit Rpn2 C-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 C-terminal domain	F: KOG1858_3rd	ECOD (1.6)
A	ANAPC1	e5g05A3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC1	ECOD (1.6)
A	KOG1858_2nd	e5g05A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Proteasome/cyclosome (PC) repeat (From Topology)	T: Proteasome/cyclosome (PC) repeat	F: KOG1858_2nd	ECOD (1.6)
A	KOG1858_1st	e5g05A2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Anaphase-promoting complex subunit 1 first helical domain (From Topology)	T: Anaphase-promoting complex subunit 1 first helical domain	F: KOG1858_1st	ECOD (1.6)
A	KOG1858_4th	e5g05A4	A: alpha superhelices	X: Repetitive alpha hairpins	H: Anaphase-promoting complex subunit 1 second helical domain (From Topology)	T: Anaphase-promoting complex subunit 1 second helical domain	F: KOG1858_4th	ECOD (1.6)
S [auth X]	TPR_19,ANAPC8	e5g05X1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_19,ANAPC8	ECOD (1.6)
T [auth Y]	TPR_11_9	e5g05Y1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_9	ECOD (1.6)
I	ANAPC4_WD40	e5g05I2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40	ECOD (1.6)
I	ANAPC4	e5g05I1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Helical bundle domain in anaphase-promoting complex subunit 4 (From Topology)	T: Helical bundle domain in anaphase-promoting complex subunit 4	F: ANAPC4	ECOD (1.6)
J	TPR_11_7	e5g05J1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_7	ECOD (1.6)
K	TPR_11_7	e5g05K1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_7	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.40.10	Alpha Beta	2-Layer Sandwich	Herpes Virus-1	Zinc/RING finger domain, C3HC4 (zinc finger)	CATH (4.3.0)
C	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
P	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
L	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
J	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
K	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF12861	Anaphase-promoting complex subunit 11 RING-H2 finger (zf-ANAPC11)	Anaphase-promoting complex subunit 11 RING-H2 finger	Apc11 is one of the subunits of the anaphase-promoting complex or cyclosome [1]. The APC subunits are cullin family proteins with ubiquitin ligase activity [2]. Polyubiquitination marks proteins for degradation by the 26S proteasome and is carried ou ...	Apc11 is one of the subunits of the anaphase-promoting complex or cyclosome [1]. The APC subunits are cullin family proteins with ubiquitin ligase activity [2]. Polyubiquitination marks proteins for degradation by the 26S proteasome and is carried out by a cascade of enzymes that includes ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s). Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo. In Saccharomyces cerevisiae this RING-H2 finger protein defines the minimal ubiquitin ligase activity of the APC, and the integrity of the RING-H2 finger is essential for budding yeast cell viability [3].	Domain
C, P	PF04049	Anaphase promoting complex subunit 8 / Cdc23 (ANAPC8)	Anaphase promoting complex subunit 8 / Cdc23	-	Repeat
F, H	PF12895	Anaphase-promoting complex, cyclosome, subunit 3 (ANAPC3)	Anaphase-promoting complex, cyclosome, subunit 3	-	Repeat
F, H	PF00515	Tetratricopeptide repeat (TPR_1)	Tetratricopeptide repeat	-	Repeat
L	PF03256	Anaphase-promoting complex, subunit 10 (APC10) (ANAPC10)	Anaphase-promoting complex, subunit 10 (APC10)	-	Family
O	PF12862	Anaphase-promoting complex subunit 5 (ANAPC5)	Anaphase-promoting complex subunit 5	-	Repeat
O	PF21371	Anaphase-promoting complex subunit 5, N-terminal domain (Apc5_N)	Anaphase-promoting complex subunit 5, N-terminal domain	This domain is found at the N-terminal end of Anaphase-promoting complex subunit 5 from humans (Apc5), a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitos ...	This domain is found at the N-terminal end of Anaphase-promoting complex subunit 5 from humans (Apc5), a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. This domain has an alpha-helical fold [1-4]. It is normally found in association with Pfam:PF12862.	Domain
A	PF20518	Anaphase-promoting complex subunit 1 middle domain (Apc1_MidN)	Anaphase-promoting complex subunit 1 middle domain	-	Repeat
A	PF18122	Anaphase-promoting complex sub unit 1 C-terminal domain (APC1_C)	Anaphase-promoting complex sub unit 1 C-terminal domain	This is the C-terminal domain of chain A, also known as sub-unit 1, found in anaphase-promoting complex (APC/C) present in Homo sapiens. APC/C is an ubiquitin ligase that controls chromosome segregation and mitotic exit [1].	Domain
A	PF21282	APC1 beta sandwich domain (APC1_3rd)	APC1 beta sandwich domain	This domain is found close to the C-terminus of the APC1 protein which is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the ce ...	This domain is found close to the C-terminus of the APC1 protein which is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.	Domain
M	PF05839	Apc13p protein (Apc13p)	Apc13p protein	-	Family
S [auth X], T [auth Y]	PF13181	Tetratricopeptide repeat (TPR_8)	Tetratricopeptide repeat	-	Repeat
S [auth X], T [auth Y]	PF13432	Tetratricopeptide repeat (TPR_16)	Tetratricopeptide repeat	-	Repeat
D	PF15243	Anaphase-promoting complex subunit 15 (ANAPC15)	Anaphase-promoting complex subunit 15	-	Family
G, R [auth W]	PF10471	Anaphase-promoting complex APC subunit CDC26 (ANAPC_CDC26)	Anaphase-promoting complex APC subunit CDC26	-	Family
I	PF12896	Anaphase-promoting complex, cyclosome, subunit 4 (ANAPC4)	Anaphase-promoting complex, cyclosome, subunit 4	Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein s ...	Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes [1,2]. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle. the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organism [3].	Domain
I	PF12894	Anaphase-promoting complex subunit 4 WD40 domain (ANAPC4_WD40)	Anaphase-promoting complex subunit 4 WD40 domain	-	Repeat
J, K	PF12895	Anaphase-promoting complex, cyclosome, subunit 3 (ANAPC3)	Anaphase-promoting complex, cyclosome, subunit 3	-	Repeat
J, K	PF13424	Tetratricopeptide repeat (TPR_12)	Tetratricopeptide repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	ANAPHASE-PROMOTING COMPLEX SUBUNIT 11	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity protein binding binding cullin family protein binding cation binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity protein binding binding cullin family protein binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular process cell cycle mitotic cell cycle catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process macromolecule metabolic process cellular process cell cycle mitotic cell cycle catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process macromolecule metabolic process protein metabolic process protein polyubiquitination protein branched polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process anaphase-promoting complex-dependent catabolic process positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation chromosome segregation regulation of cell cycle process positive regulation of nuclear division sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle cellular component organization or biogenesis positive regulation of cellular process cell cycle process mitotic nuclear division organelle fission chromosome organization positive regulation of cell cycle organelle organization nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition protein K11-linked ubiquitination protein K48-linked ubiquitination cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cytoplasm cytosol nucleoplasm
C, P	CELL DIVISION CYCLE PROTEIN 23 HOMOLOG	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity	cellular process cell cycle mitotic cell cycle catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process macromolecule metabolic process cellular process cell cycle mitotic cell cycle catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process macromolecule metabolic process protein metabolic process protein polyubiquitination protein branched polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization regulation of mitotic cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation cell cycle process regulation of biological process regulation of cell cycle process biological regulation chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process anaphase-promoting complex-dependent catabolic process positive regulation of organelle organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation positive regulation of nuclear division regulation of chromosome separation regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle positive regulation of cellular process mitotic nuclear division organelle fission positive regulation of cell cycle nuclear division chromosome separation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division positive regulation of chromosome separation protein K11-linked ubiquitination protein K48-linked ubiquitination exit from mitosis regulation of exit from mitosis cell division establishment of organelle localization cellular localization mitotic metaphase chromosome alignment metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell establishment of localization establishment of chromosome localization regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex cellular anatomical structure nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex cellular anatomical structure nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
E	ANAPHASE-PROMOTING COMPLEX SUBUNIT 16	-	protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cell cycle regulation of cell cycle mitotic cell cycle catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process protein K11-linked ubiquitination protein K48-linked ubiquitination cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	intracellular anatomical structure intracellular membraneless organelle chromosome chromosomal region kinetochore intracellular organelle cellular anatomical structure organelle membraneless organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome membrane-bounded organelle intracellular anatomical structure intracellular membraneless organelle chromosome chromosomal region kinetochore intracellular organelle cellular anatomical structure organelle membraneless organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
F, H	CELL DIVISION CYCLE PROTEIN 27 HOMOLOG	protein phosphatase binding phosphatase binding protein binding binding enzyme binding	protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cell cycle regulation of cell cycle mitotic cell cycle regulation of chromosome segregation regulation of cellular component organization cell cycle phase transition cellular component organization cellular component organization or biogenesis chromosome segregation cell cycle process regulation of cell cycle process chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process protein K11-linked ubiquitination protein K48-linked ubiquitination cell division developmental process multicellular organismal process plasma membrane bounded cell projection organization cellular developmental process cell projection organization cell development neuron projection development nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation neuron development anatomical structure development system development regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	intracellular organelle centrosome microtubule organizing center cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex intracellular organelle centrosome microtubule organizing center cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cytoplasm cytosol spindle mitotic spindle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
L	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10	-	protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cell cycle regulation of cell cycle mitotic cell cycle catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process protein K11-linked ubiquitination protein K48-linked ubiquitination cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex cellular anatomical structure nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex cellular anatomical structure nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
N	ANAPHASE-PROMOTING COMPLEX SUBUNIT 2	ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding	protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal developmental process protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal developmental process cellular developmental process cell differentiation multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization regulation of developmental process positive regulation of biological process cellular component organization positive regulation of developmental process multicellular organism development anatomical structure development regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality positive regulation of cellular process system development regulation of biological process biological regulation nervous system development developmental maturation synapse maturation regulation of synapse organization regulation of synapse maturation cell junction organization positive regulation of synapse maturation regulation of mitotic cell cycle cell cycle regulation of cell cycle mitotic cell cycle catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process cell division axon extension positive regulation of nervous system development regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development cell projection morphogenesis neuron differentiation neuron projection morphogenesis positive regulation of cell projection organization positive regulation of developmental growth regulation of cell projection organization positive regulation of cell development developmental growth involved in morphogenesis generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis regulation of axon extension regulation of nervous system development neurogenesis regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of axon extension positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation positive regulation of growth anatomical structure morphogenesis neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size regulation of synaptic plasticity trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission signaling cell-cell signaling chemical synaptic transmission cell communication positive regulation of synaptic plasticity synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle regulation of chromosome segregation cell cycle phase transition chromosome segregation cell cycle process regulation of cell cycle process chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition protein K11-linked ubiquitination protein K48-linked ubiquitination regulation of biosynthetic process negative regulation of metabolic process negative regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of cellular process regulation of macromolecule biosynthetic process regulation of metabolic process negative regulation of macromolecule metabolic process regulation of cell morphogenesis regulation of dendrite morphogenesis positive regulation of cell morphogenesis regulation of dendrite development dendrite development positive regulation of dendrite morphogenesis dendrite morphogenesis	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex
O	ANAPHASE-PROMOTING COMPLEX SUBUNIT 5	protein phosphatase binding phosphatase binding protein binding binding enzyme binding	protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cell cycle regulation of cell cycle mitotic cell cycle catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation chromosome segregation regulation of cell cycle process positive regulation of nuclear division sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle cellular component organization or biogenesis positive regulation of cellular process cell cycle process mitotic nuclear division organelle fission chromosome organization positive regulation of cell cycle organelle organization nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition protein K11-linked ubiquitination protein K48-linked ubiquitination cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex cellular anatomical structure nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex cellular anatomical structure nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol cytoskeleton spindle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
Q [auth T]	UNIDENTIFIED PEPTIDE	-	-	-
A	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1	molecular adaptor activity	protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cell cycle regulation of cell cycle mitotic cell cycle regulation of chromosome segregation regulation of cellular component organization cell cycle phase transition cellular component organization cellular component organization or biogenesis chromosome segregation cell cycle process regulation of cell cycle process chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process protein K11-linked ubiquitination protein K48-linked ubiquitination cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex cellular anatomical structure nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex cellular anatomical structure nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
M	ANAPHASE-PROMOTING COMPLEX SUBUNIT 13	-	protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal catabolic process protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process protein K11-linked ubiquitination protein K48-linked ubiquitination cell division	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex cellular anatomical structure nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex cellular anatomical structure nuclear ubiquitin ligase complex organelle intracellular protein-containing complex
S [auth X], T [auth Y]	ANAPHASE-PROMOTING COMPLEX SUBUNIT 7	enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity protein phosphatase binding phosphatase binding protein binding binding enzyme binding	developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cell cycle regulation of cell cycle mitotic cell cycle catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation chromosome segregation regulation of cell cycle process positive regulation of nuclear division sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle cellular component organization or biogenesis positive regulation of cellular process cell cycle process mitotic nuclear division organelle fission chromosome organization positive regulation of cell cycle organelle organization nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition protein K11-linked ubiquitination protein K48-linked ubiquitination cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	intercellular bridge cellular anatomical structure intracellular organelle intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome heterochromatin membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex intercellular bridge cellular anatomical structure intracellular organelle intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome heterochromatin membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cytoplasm cytosol cytoskeleton spindle microtubule cytoskeleton mitotic spindle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
D	ANAPHASE-PROMOTING COMPLEX SUBUNIT 15	-	protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cell cycle regulation of cell cycle mitotic cell cycle catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process protein K11-linked ubiquitination protein K48-linked ubiquitination regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle cell division cellular response to stimulus regulation of cell cycle phase transition response to stimulus negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of signal transduction regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication regulation of cell cycle checkpoint negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction mitotic sister chromatid separation chromosome segregation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling negative regulation of cellular component organization regulation of cell cycle process regulation of spindle checkpoint sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation mitotic cell cycle process regulation of response to stimulus regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of cellular component organization regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle regulation of mitotic spindle checkpoint signaling regulation of mitotic cell cycle spindle assembly checkpoint spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization regulation of intracellular signal transduction negative regulation of cellular process mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition cellular component organization or biogenesis negative regulation of chromosome separation cell cycle process mitotic nuclear division regulation of signaling negative regulation of mitotic cell cycle phase transition organelle fission chromosome organization negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling organelle organization nuclear division negative regulation of chromosome segregation negative regulation of nuclear division negative regulation of organelle organization chromosome separation regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle regulation of cell communication metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex
G, R [auth W]	ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26	-	protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cell cycle regulation of cell cycle mitotic cell cycle catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process protein K11-linked ubiquitination protein K48-linked ubiquitination regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle cell division	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex
I	ANAPHASE-PROMOTING COMPLEX SUBUNIT 4	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity protein phosphatase binding phosphatase binding protein binding binding enzyme binding	protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of chromosome segregation protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation cell cycle process regulation of biological process regulation of cell cycle process biological regulation chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process protein K11-linked ubiquitination protein K48-linked ubiquitination cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex cellular anatomical structure nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex cellular anatomical structure nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen nucleoplasm
J, K	CELL DIVISION CYCLE PROTEIN 16 HOMOLOG	-	protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle protein polyubiquitination protein branched polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cell cycle regulation of cell cycle mitotic cell cycle catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation chromosome segregation regulation of cell cycle process positive regulation of nuclear division sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle cellular component organization or biogenesis positive regulation of cellular process cell cycle process mitotic nuclear division organelle fission chromosome organization positive regulation of cell cycle organelle organization nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition protein K11-linked ubiquitination protein K48-linked ubiquitination cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	intracellular organelle centrosome microtubule organizing center cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex intracellular organelle centrosome microtubule organizing center cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cytoplasm cytosol mitotic spindle spindle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR051031	RING-box E3 Ubiquitin Ligase	Family
B	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
B	IPR024991	Anaphase-promoting complex subunit 11, RING-H2 finger	Domain
B	IPR001841	Zinc finger, RING-type	Domain
C, P	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
C, P	IPR007192	Cdc23	Domain
C, P	IPR019734	Tetratricopeptide repeat	Repeat
E	IPR029641	Anaphase-promoting complex subunit 16	Family
F, H	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
F, H	IPR019734	Tetratricopeptide repeat	Repeat
L	IPR016901	Anaphase-promoting complex subunit APC10/Doc1	Family
L	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
L	IPR004939	APC10/DOC domain	Domain
N	IPR014786	Anaphase-promoting complex subunit 2, C-terminal	Domain
N	IPR016158	Cullin homology domain	Domain
N	IPR001373	Cullin, N-terminal	Domain
N	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
N	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
N	IPR036317	Cullin homology domain superfamily	Homologous Superfamily
N	IPR044554	Anaphase-promoting complex subunit 2	Family
O	IPR026000	Anaphase-promoting complex subunit 5 domain	Domain
O	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
O	IPR037679	Anaphase-promoting complex subunit 5	Family
O	IPR019734	Tetratricopeptide repeat	Repeat
O	IPR048968	Anaphase-promoting complex subunit 5, N-terminal domain	Domain
A	IPR041221	Anaphase-promoting complex subunit 1, C-terminal	Domain
A	IPR046794	Anaphase-promoting complex subunit 1, middle domain	Domain
A	IPR024990	Anaphase-promoting complex subunit 1	Family
A	IPR048971	Anaphase-promoting complex subunit 1, beta-sandwich domain	Domain
A	IPR049255	Anaphase-promoting complex subunit 1, N-terminal domain	Domain
A	IPR011989	Armadillo-like helical	Homologous Superfamily
M	IPR008401	Apc13	Family
S [auth X], T [auth Y]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
S [auth X], T [auth Y]	IPR019734	Tetratricopeptide repeat	Repeat
D	IPR026182	Anaphase-promoting complex subunit 15	Family
G, R [auth W]	IPR018860	Anaphase-promoting complex, subunit CDC26	Family
I	IPR017169	Anaphase-promoting complex subunit 4, metazoa	Family
I	IPR024977	Anaphase-promoting complex subunit 4-like, WD40 domain	Domain
I	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
I	IPR024789	Anaphase-promoting complex subunit 4	Family
I	IPR024790	Anaphase-promoting complex subunit 4, long domain	Domain
I	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
I	IPR056358	Anaphase-promoting complex subunit 4, C-terminal half WD40 domain	Domain
J, K	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
J, K	IPR019734	Tetratricopeptide repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: Q9NYG5	attention deficit hyperactivity disorder, inattentive type
C, P	Pharos: Q9UJX2	adrenal cortex carcinoma dermatomyositis ovarian cancer Sjogren syndrome astrocytic tumor invasive ductal breast carcinoma pancreatic intraductal papillary-mucinous carcinoma atrial fibrillation medulloblastoma pancreatic intraductal papillary-mucinous neoplasm
E	Pharos: Q96DE5	malignant ependymoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma Sjogren syndrome osteosarcoma pancreatic intraductal papillary-mucinous carcinoma
F, H	Pharos: P30260	prostate cancer atypical teratoid rhabdoid tumor large cell medulloblastoma medulloblastoma ulcerative colitis Crohn disease lung cancer osteosarcoma Prostatic Neoplasms glioblastoma ovarian cancer psoriasis
L	Pharos: Q9UM13	atrial fibrillation large cell medulloblastoma psoriasis colorectal adenoma non-alcoholic fatty liver disease colorectal cancer ovarian cancer
N	Pharos: Q9UJX6	glioblastoma malignant ependymoma oligodendroglioma
O	Pharos: Q9UJX4	non-small cell lung carcinoma ovarian cancer psoriasis adrenal cortex carcinoma bipolar disorder endogenous depression interstitial lung disease lung adenocarcinoma malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma Sjogren syndrome astrocytic tumor congestive heart failure non-small cell lung carcinoma ovarian cancer psoriasis adrenal cortex carcinoma bipolar disorder endogenous depression interstitial lung disease lung adenocarcinoma malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma Sjogren syndrome astrocytic tumor congestive heart failure Gaucher disease juvenile dermatomyositis lung cancer Malignant neoplasm of breast myopathy osteosarcoma Pick disease atypical teratoid rhabdoid tumor diabetes mellitus glioblastoma large cell medulloblastoma lung carcinoma MALT lymphoma
A	Pharos: Q9H1A4	Alcoholic Intoxication, Chronic heart disease atopic eczema hypotrichosis glioblastoma
S [auth X], T [auth Y]	Pharos: Q9UJX3	anorexia nervosa osteosarcoma autism spectrum disorder pancreatic intraductal papillary-mucinous neoplasm bipolar disorder Pick disease
D	Pharos: P60006	astrocytic tumor osteosarcoma psoriasis
G, R [auth W]	Pharos: Q8NHZ8	diabetes mellitus
I	Pharos: Q9UJX5	colorectal cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia osteosarcoma ovarian cancer
J, K	Pharos: Q13042	lymphoplasmacytic lymphoma nodular sclerosis classical Hodgkin lymphoma pancreatic ductal adenocarcinoma malignant colon neoplasm osteosarcoma Pick disease medulloblastoma ovarian cancer