Annotations: 5A9Q

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
K [auth A]	SCOP2B Superfamily	Nucleoporin beta-propeller domain	8090969	3000456	SCOP2B (2022-06-29)
L [auth B]	SCOP2 Family	Nup170 CTD-like	8051189	4007235	SCOP2 (2022-06-29)
L [auth B]	SCOP2 Family	Adaptor nucleoporins Nup170/Nup155 NTD-like	8051248	4007265	SCOP2 (2022-06-29)
L [auth B]	SCOP2 Superfamily	Scaffolding nucleoporins	8090958	3002255	SCOP2 (2022-06-29)
L [auth B]	SCOP2 Superfamily	Nucleoporin beta-propeller domain	8090969	3000456	SCOP2 (2022-06-29)
B [auth 1]	SCOP2 Family	Coat nucleoporins Nup120/Nup160 NTD-like	8046889	4005351	SCOP2 (2022-06-29)
B [auth 1]	SCOP2 Family	Nup120 CTD-like	8090983	4007717	SCOP2 (2022-06-29)
B [auth 1]	SCOP2 Superfamily	Nucleoporin beta-propeller domain	8090976	3000456	SCOP2 (2022-06-29)
B [auth 1]	SCOP2 Superfamily	Scaffolding nucleoporins	8090984	3002255	SCOP2 (2022-06-29)
CA [auth S]	SCOP2B Superfamily	Scaffolding nucleoporins	8090984	3002255	SCOP2B (2022-06-29)
CA [auth S]	SCOP2B Superfamily	Nucleoporin beta-propeller domain	8090976	3000456	SCOP2B (2022-06-29)
KA [auth a]	SCOP2B Superfamily	Nucleoporin beta-propeller domain	8090976	3000456	SCOP2B (2022-06-29)
KA [auth a]	SCOP2B Superfamily	Scaffolding nucleoporins	8090984	3002255	SCOP2B (2022-06-29)
T [auth J]	SCOP2B Superfamily	Nucleoporin beta-propeller domain	8090976	3000456	SCOP2B (2022-06-29)
T [auth J]	SCOP2B Superfamily	Scaffolding nucleoporins	8090984	3002255	SCOP2B (2022-06-29)
D [auth 3]	SCOP2B Superfamily	Scaffolding nucleoporins	8090957	3002255	SCOP2B (2022-06-29)
EA [auth U]	SCOP2B Superfamily	Scaffolding nucleoporins	8090957	3002255	SCOP2B (2022-06-29)
M [auth C]	SCOP2B Superfamily	Scaffolding nucleoporins	8090957	3002255	SCOP2B (2022-06-29)
V [auth L]	SCOP2B Superfamily	Scaffolding nucleoporins	8090957	3002255	SCOP2B (2022-06-29)
F [auth 5]	SCOP2 Family	Nucleoporin NUP145/NUP98	8047217	4005510	SCOP2 (2022-06-29)
F [auth 5]	SCOP2 Superfamily	Coat and nuclear envelope proteins	8054128	3002276	SCOP2 (2022-06-29)
GA [auth W]	SCOP2B Superfamily	Coat and nuclear envelope proteins	8054128	3002276	SCOP2B (2022-06-29)
O [auth E]	SCOP2B Superfamily	Coat and nuclear envelope proteins	8054128	3002276	SCOP2B (2022-06-29)
X [auth N]	SCOP2B Superfamily	Coat and nuclear envelope proteins	8054128	3002276	SCOP2B (2022-06-29)
AA [auth Q]	SCOP2B Superfamily	Coat and nuclear envelope proteins	8054125	3002276	SCOP2B (2022-06-29)
I [auth 8]	SCOP2B Superfamily	Coat and nuclear envelope proteins	8054125	3002276	SCOP2B (2022-06-29)
JA [auth Z]	SCOP2 Family	Nucleoporin NUP85	8049734	4006614	SCOP2 (2022-06-29)
JA [auth Z]	SCOP2 Superfamily	Coat and nuclear envelope proteins	8054125	3002276	SCOP2 (2022-06-29)
R [auth H]	SCOP2B Superfamily	Coat and nuclear envelope proteins	8054125	3002276	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth 0]	ANAPC4_WD40_2	e5a9q01	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_2	ECOD (1.6)
BA [auth R]	ANAPC4_WD40_2	e5a9qR1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_2	ECOD (1.6)
J [auth 9]	ANAPC4_WD40_2	e5a9q91	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_2	ECOD (1.6)
S [auth I]	ANAPC4_WD40_2	e5a9qI1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_2	ECOD (1.6)
K [auth A]	Nucleoporin_N	e5a9qA2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Nucleoporin_N	ECOD (1.6)
K [auth A]	Nucleoporin_C_C	e5a9qA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_C	ECOD (1.6)
K [auth A]	Nucleoporin_C_N	e5a9qA3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_N	ECOD (1.6)
L [auth B]	Nucleoporin_N	e5a9qB2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Nucleoporin_N	ECOD (1.6)
L [auth B]	Nucleoporin_C_C	e5a9qB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_C	ECOD (1.6)
L [auth B]	Nucleoporin_C_N	e5a9qB3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_N	ECOD (1.6)
B [auth 1]	Nup160	e5a9q12	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Nup160	ECOD (1.6)
B [auth 1]	KOG4521_1st	e5a9q13	A: alpha arrays	X: Nucleoporin NUP120 helical domain (From Topology)	H: Nucleoporin NUP120 helical domain (From Topology)	T: Nucleoporin NUP120 helical domain	F: KOG4521_1st	ECOD (1.6)
B [auth 1]	KOG4521_2nd	e5a9q11	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: KOG4521_2nd	ECOD (1.6)
CA [auth S]	Nup160	e5a9qS2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Nup160	ECOD (1.6)
CA [auth S]	KOG4521_1st	e5a9qS3	A: alpha arrays	X: Nucleoporin NUP120 helical domain (From Topology)	H: Nucleoporin NUP120 helical domain (From Topology)	T: Nucleoporin NUP120 helical domain	F: KOG4521_1st	ECOD (1.6)
CA [auth S]	KOG4521_2nd	e5a9qS1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: KOG4521_2nd	ECOD (1.6)
KA [auth a]	Nup160	e5a9qa2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Nup160	ECOD (1.6)
KA [auth a]	KOG4521_1st	e5a9qa3	A: alpha arrays	X: Nucleoporin NUP120 helical domain (From Topology)	H: Nucleoporin NUP120 helical domain (From Topology)	T: Nucleoporin NUP120 helical domain	F: KOG4521_1st	ECOD (1.6)
KA [auth a]	KOG4521_2nd	e5a9qa1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: KOG4521_2nd	ECOD (1.6)
T [auth J]	Nup160	e5a9qJ2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Nup160	ECOD (1.6)
T [auth J]	KOG4521_1st	e5a9qJ3	A: alpha arrays	X: Nucleoporin NUP120 helical domain (From Topology)	H: Nucleoporin NUP120 helical domain (From Topology)	T: Nucleoporin NUP120 helical domain	F: KOG4521_1st	ECOD (1.6)
T [auth J]	KOG4521_2nd	e5a9qJ1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: KOG4521_2nd	ECOD (1.6)
C [auth 2]	ANAPC4_WD40_10	e5a9q21	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
DA [auth T]	ANAPC4_WD40_10	e5a9qT1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
LA [auth b]	ANAPC4_WD40_10	e5a9qb1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
U [auth K]	ANAPC4_WD40_10	e5a9qK1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
D [auth 3]	Nucleoporin_C_C	e5a9q31	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_C	ECOD (1.6)
EA [auth U]	Nucleoporin_C_C	e5a9qU1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_C	ECOD (1.6)
M [auth C]	Nucleoporin_C_C	e5a9qC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_C	ECOD (1.6)
V [auth L]	Nucleoporin_C_C	e5a9qL1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: Nucleoporin_C_C	ECOD (1.6)
E [auth 4]	Nup84_Nup100	e5a9q42	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin Nup84/Nup107 (From Topology)	T: Nucleoporin Nup84/Nup107	F: Nup84_Nup100	ECOD (1.6)
FA [auth V]	Nup84_Nup100	e5a9qV2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin Nup84/Nup107 (From Topology)	T: Nucleoporin Nup84/Nup107	F: Nup84_Nup100	ECOD (1.6)
N [auth D]	Nup84_Nup100	e5a9qD2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin Nup84/Nup107 (From Topology)	T: Nucleoporin Nup84/Nup107	F: Nup84_Nup100	ECOD (1.6)
W [auth M]	Nup84_Nup100	e5a9qM2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin Nup84/Nup107 (From Topology)	T: Nucleoporin Nup84/Nup107	F: Nup84_Nup100	ECOD (1.6)
F [auth 5]	Nup96	e5a9q51	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: Nup96	ECOD (1.6)
GA [auth W]	Nup96	e5a9qW1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: Nup96	ECOD (1.6)
O [auth E]	Nup96	e5a9qE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: Nup96	ECOD (1.6)
X [auth N]	Nup96	e5a9qN1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: Nup96	ECOD (1.6)
G [auth 6]	ANAPC4_WD40_4	e5a9q61	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_4	ECOD (1.6)
HA [auth X]	ANAPC4_WD40_4	e5a9qX1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_4	ECOD (1.6)
P [auth F]	ANAPC4_WD40_4	e5a9qF1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_4	ECOD (1.6)
Y [auth O]	ANAPC4_WD40_4	e5a9qO1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_4	ECOD (1.6)
H [auth 7]	ANAPC4_WD40_6	e5a9q71	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_6	ECOD (1.6)
IA [auth Y]	ANAPC4_WD40_6	e5a9qY1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_6	ECOD (1.6)
Q [auth G]	ANAPC4_WD40_6	e5a9qG1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_6	ECOD (1.6)
Z [auth P]	ANAPC4_WD40_6	e5a9qP1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_6	ECOD (1.6)
AA [auth Q]	Nucleopor_Nup85	e5a9qQ1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: Nucleopor_Nup85	ECOD (1.6)
I [auth 8]	Nucleopor_Nup85	e5a9q81	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: Nucleopor_Nup85	ECOD (1.6)
JA [auth Z]	Nucleopor_Nup85	e5a9qZ1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: Nucleopor_Nup85	ECOD (1.6)
R [auth H]	Nucleopor_Nup85	e5a9qH1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: Nucleopor_Nup85	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth 0], BA [auth R], J [auth 9], S [auth I]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
K [auth A], L [auth B]	PF03177	Non-repetitive/WGA-negative nucleoporin C-terminal (Nucleoporin_C)	Non-repetitive/WGA-negative nucleoporin C-terminal	-	Repeat
K [auth A], L [auth B]	PF11715	Nucleoporin Nup120/160, beta-propeller domain (Beta-prop_Nup120_160)	Nucleoporin Nup120/160, beta-propeller domain	-	Repeat
K [auth A], L [auth B]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
K [auth A], L [auth B]	PF08801	Nup133 N terminal like (Nucleoporin_N)	Nup133 N terminal like	-	Repeat
B [auth 1], CA [auth S], KA [auth a], T [auth J]	PF11715	Nucleoporin Nup120/160, beta-propeller domain (Beta-prop_Nup120_160)	Nucleoporin Nup120/160, beta-propeller domain	-	Repeat
C [auth 2], DA [auth T], LA [auth b], U [auth K]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
D [auth 3], EA [auth U], M [auth C], V [auth L]	PF03177	Non-repetitive/WGA-negative nucleoporin C-terminal (Nucleoporin_C)	Non-repetitive/WGA-negative nucleoporin C-terminal	-	Repeat
E [auth 4], FA [auth V], N [auth D], W [auth M]	PF04121	Nuclear pore protein 84 / 107 (Nup84_Nup100)	Nuclear pore protein 84 / 107	-	Family
F [auth 5], GA [auth W], O [auth E], X [auth N]	PF12110	Nuclear protein 96 (Nup96)	Nuclear protein 96	Nup96 (often known by the name of its yeast homolog Nup145C) is part of the Nup84 heptameric complex in the nuclear pore complex. Nup96 complexes with Sec13 in the middle of the heptamer. The function of the heptamer is to coat the curvature of the n ...	Nup96 (often known by the name of its yeast homolog Nup145C) is part of the Nup84 heptameric complex in the nuclear pore complex. Nup96 complexes with Sec13 in the middle of the heptamer. The function of the heptamer is to coat the curvature of the nuclear pore complex between the inner and outer nuclear membranes. Nup96 is predicted to be an alpha helical solenoid. The interaction between Nup96 and Sec13 is the point of curvature in the heptameric complex. [1] [2]	Domain
G [auth 6], HA [auth X], P [auth F], Y [auth O]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
H [auth 7], IA [auth Y], Q [auth G], Z [auth P]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
AA [auth Q], I [auth 8], JA [auth Z], R [auth H]	PF07575	Nup85 Nucleoporin (Nucleopor_Nup85)	Nup85 Nucleoporin	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 0], BA [auth R], J [auth 9], S [auth I]	NUCLEOPORIN NUP43	-	RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cellular process cell division cell cycle RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cellular process cell division cell cycle chromosome segregation cell cycle process protein localization establishment of protein localization cellular localization protein transport cellular macromolecule localization nucleocytoplasmic transport nuclear transport establishment of localization in cell intracellular transport	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore intracellular membraneless organelle chromosome chromosomal region kinetochore membraneless organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen cytoplasm cytosol
K [auth A], L [auth B]	NUCLEAR PORE COMPLEX PROTEIN NUP155	structural molecule activity structural constituent of nuclear pore	membrane organization cellular component organization nucleus organization organelle organization nuclear envelope organization cellular process cellular component organization or biogenesis endomembrane system organization heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling membrane organization cellular component organization nucleus organization organelle organization nuclear envelope organization cellular process cellular component organization or biogenesis endomembrane system organization heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling regulation of heart contraction regulation of system process cell-cell signaling involved in cardiac conduction cardiac muscle contraction striated muscle contraction cell communication circulatory system process actin filament-based process regulation of multicellular organismal process regulation of biological quality atrial cardiac muscle cell to AV node cell communication cell communication involved in cardiac conduction blood circulation cardiac muscle cell contraction regulation of biological process atrial cardiac muscle cell action potential biological regulation cell-cell signaling action potential actin filament-based movement muscle contraction muscle system process regulation of blood circulation cardiac conduction actin-mediated cell contraction heart contraction cardiac muscle cell action potential regulation of membrane potential chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization metabolic process macromolecule metabolic process protein localization protein localization to nucleus localization within membrane protein localization to membrane protein localization to nuclear envelope protein localization to organelle cellular macromolecule localization protein localization to nuclear inner membrane establishment of protein localization import into nucleus establishment of protein localization to organelle protein transport protein import into nucleus intracellular protein transport regulation of cellular process negative regulation of biological process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of cellular process RNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process miRNA processing regulation of macromolecule biosynthetic process regulation of metabolic process	cellular anatomical structure membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane organelle membrane nuclear pore inner ring cellular anatomical structure membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane organelle membrane nuclear pore inner ring protein-containing complex nuclear protein-containing complex nuclear pore cytoplasm cytosol
B [auth 1], CA [auth S], KA [auth a], T [auth J]	NUCLEAR PORE COMPLEX PROTEIN NUP160	structural molecule activity structural constituent of nuclear pore	cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process protein localization establishment of protein localization protein transport cellular macromolecule localization developmental process multicellular organism development multicellular organismal process anatomical structure development animal organ development nephron development kidney development renal system development system development	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore cytoplasm cytosol
C [auth 2], DA [auth T], LA [auth b], U [auth K]	NUCLEOPORIN NUP37	-	RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cellular process cell division cell cycle RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cellular process cell division cell cycle chromosome segregation cell cycle process protein localization establishment of protein localization cellular localization protein transport cellular macromolecule localization nucleocytoplasmic transport nuclear transport establishment of localization in cell intracellular transport	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore intracellular membraneless organelle chromosome chromosomal region kinetochore membraneless organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
D [auth 3], EA [auth U], M [auth C], V [auth L]	NUCLEAR PORE COMPLEX PROTEIN NUP133	structural molecule activity structural constituent of nuclear pore	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis developmental process paraxial mesoderm development animal organ development anatomical structure development mesenchyme development tissue development mesoderm development cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis developmental process paraxial mesoderm development animal organ development anatomical structure development mesenchyme development tissue development mesoderm development cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization metabolic process macromolecule metabolic process neurogenesis multicellular organism development multicellular organismal process cellular developmental process cell differentiation nervous system development system development chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery epithelium development neural tube development tube development chordate embryonic development embryo development embryo development ending in birth or egg hatching nephron development kidney development renal system development protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport somite development	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane intracellular membraneless organelle chromosome chromosomal region kinetochore membraneless organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome nuclear membrane organelle membrane cytoplasm cytosol
E [auth 4], FA [auth V], N [auth D], W [auth M]	NUCLEAR PORE COMPLEX PROTEIN NUP107	structural molecule activity structural constituent of nuclear pore	cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process cellular component organization organelle organization chromosome organization cellular component organization or biogenesis transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery developmental process multicellular organism development multicellular organismal process anatomical structure development animal organ development nephron development kidney development renal system development system development nuclear pore organization protein-containing complex organization pore complex assembly cellular component biogenesis nuclear pore complex assembly nucleus organization cellular component assembly protein-containing complex assembly protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport gonad development reproductive system development reproductive process female gonad development sex differentiation female sex differentiation development of primary female sexual characteristics developmental process involved in reproduction development of primary sexual characteristics reproductive structure development	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane intracellular membraneless organelle chromosome chromosomal region kinetochore membraneless organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome nuclear membrane organelle membrane cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen
F [auth 5], GA [auth W], O [auth E], X [auth N]	NUCLEAR PORE COMPLEX PROTEIN NUP96	molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity transcription coactivator activity transcription regulator activity transcription coregulator activity peptidase activity serine hydrolase activity catalytic activity, acting on a protein serine-type peptidase activity hydrolase activity catalytic activity RNA binding binding molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity transcription coactivator activity transcription regulator activity transcription coregulator activity peptidase activity serine hydrolase activity catalytic activity, acting on a protein serine-type peptidase activity hydrolase activity catalytic activity RNA binding binding nucleic acid binding nuclear localization sequence binding signal sequence binding peptide binding chromatin binding promoter-specific chromatin binding mRNA binding structural molecule activity structural constituent of nuclear pore	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization RNA transport nitrogen compound transport cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cellular localization nucleocytoplasmic transport nuclear transport establishment of localization in cell intracellular transport protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport RNA export from nucleus nuclear export chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery pore complex assembly cellular component biogenesis nuclear pore complex assembly cellular component assembly protein-containing complex assembly proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process regulation of cellular process regulation of mRNA splicing, via spliceosome mRNA processing positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process RNA processing regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of mRNA processing regulation of macromolecule biosynthetic process regulation of metabolic process positive regulation of mRNA splicing, via spliceosome positive regulation of biological process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of biosynthetic process regulation of mRNA processing RNA splicing biological regulation regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process regulation of RNA splicing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process RNA splicing, via transesterification reactions positive regulation of gene expression mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulation of mRNA metabolic process positive regulation of RNA splicing	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen nucleoplasm nuclear pore nuclear basket inclusion body nuclear inclusion body ribonucleoprotein complex nuclear body nuclear pore cytoplasmic filaments
G [auth 6], HA [auth X], P [auth F], Y [auth O]	PROTEIN SEC13 HOMOLOG	structural molecule activity identical protein binding protein binding binding	protein localization protein exit from endoplasmic reticulum cellular localization establishment of protein localization nitrogen compound transport transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process protein localization protein exit from endoplasmic reticulum cellular localization establishment of protein localization nitrogen compound transport transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport membrane organization vesicle budding from membrane endoplasmic reticulum to Golgi vesicle-mediated transport vesicle-mediated transport cellular component organization vesicle organization organelle organization cellular component organization or biogenesis COPII-coated vesicle budding Golgi vesicle transport RNA transport nucleic acid transport mRNA transport establishment of RNA localization RNA localization nucleobase-containing compound transport cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling nucleocytoplasmic transport nuclear transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein localization to organelle protein import into nucleus positive regulation of TORC1 signaling regulation of TORC1 signaling TORC1 signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process negative regulation of cell communication negative regulation of TORC1 signaling negative regulation of TOR signaling negative regulation of cellular process negative regulation of response to stimulus negative regulation of signal transduction vesicle cargo loading COPII-coated vesicle cargo loading	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol vesicle coat intracellular vesicle transport vesicle membrane membrane protein complex membrane coat bounding membrane of organelle vesicle membrane cytoplasmic vesicle ER to Golgi transport vesicle membrane coated vesicle transport vesicle membrane coated membrane COPII vesicle coat cytoplasmic vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle organelle membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen GATOR2 complex Seh1-associated complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome
H [auth 7], IA [auth Y], Q [auth G], Z [auth P]	NUCLEOPORIN SEH1	structural molecule activity	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport establishment of organelle localization cellular localization mitotic metaphase chromosome alignment mitotic cell cycle metaphase chromosome alignment chromosome localization organelle localization establishment of localization in cell mitotic sister chromatid segregation cell cycle chromosome segregation cell cycle process mitotic nuclear division attachment of spindle microtubules to kinetochore organelle fission attachment of mitotic spindle microtubules to kinetochore chromosome organization sister chromatid segregation nuclear division mitotic cell cycle process nuclear chromosome segregation establishment of chromosome localization cell division cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus protein localization establishment of protein localization protein transport cellular macromolecule localization nucleocytoplasmic transport nuclear transport intracellular transport protein-containing complex localization positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction regulation of TORC1 signaling positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication TORC1 signaling positive regulation of signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process negative regulation of cell communication negative regulation of TORC1 signaling negative regulation of TOR signaling negative regulation of cellular process negative regulation of response to stimulus negative regulation of signal transduction cellular response to amino acid starvation cellular response to starvation cellular response to stress response to stress response to amino acid starvation response to starvation biological process involved in interspecies interaction between organisms response to other organism defense response defense response to Gram-positive bacterium response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore cytoplasm cytosol GATOR2 complex Seh1-associated complex vacuolar membrane membrane lytic vacuole vacuole lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane lysosome intracellular membraneless organelle chromosome chromosomal region kinetochore membraneless organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome
AA [auth Q], I [auth 8], JA [auth Z], R [auth H]	NUCLEAR PORE COMPLEX PROTEIN NUP85	structural molecule activity structural constituent of nuclear pore	lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular process cellular component organization or biogenesis cell projection assembly cell chemotaxis cellular response to stimulus chemotaxis lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular process cellular component organization or biogenesis cell projection assembly cell chemotaxis cellular response to stimulus chemotaxis response to stimulus macrophage chemotaxis response to external stimulus macrophage migration leukocyte migration cellular response to chemical stimulus taxis immune system process response to chemical mononuclear cell migration myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization metabolic process macromolecule metabolic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process developmental process multicellular organism development multicellular organismal process anatomical structure development animal organ development nephron development kidney development renal system development system development protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane intracellular membraneless organelle chromosome chromosomal region kinetochore membraneless organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome nuclear membrane organelle membrane cytoskeleton actin cytoskeleton cytoplasm cytosol spindle microtubule cytoskeleton membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cilium plasma membrane bounded cell projection ciliary basal body cell projection microtubule organizing center

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth 0], BA [auth R], J [auth 9], S [auth I]	IPR019775	WD40 repeat, conserved site	Conserved Site
A [auth 0], BA [auth R], J [auth 9], S [auth I]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A [auth 0], BA [auth R], J [auth 9], S [auth I]	IPR001680	WD40 repeat	Repeat
A [auth 0], BA [auth R], J [auth 9], S [auth I]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
K [auth A], L [auth B]	IPR042537	Nucleoporin, Nup155-like, C-terminal, subdomain 2	Homologous Superfamily
K [auth A], L [auth B]	IPR042533	Nucleoporin, Nup155-like, C-terminal, subdomain 1	Homologous Superfamily
K [auth A], L [auth B]	IPR042538	Nucleoporin, Nup155-like, C-terminal, subdomain 3	Homologous Superfamily
K [auth A], L [auth B]	IPR014908	Nucleoporin, Nup133/Nup155-like, N-terminal	Domain
K [auth A], L [auth B]	IPR004870	Nucleoporin, Nup155-like	Family
K [auth A], L [auth B]	IPR007187	Nucleoporin, Nup133/Nup155-like, C-terminal	Domain
B [auth 1], CA [auth S], KA [auth a], T [auth J]	IPR021717	Nucleoporin Nup120/160	Family
B [auth 1], CA [auth S], KA [auth a], T [auth J]	IPR056547	NUP160, helical domain	Domain
B [auth 1], CA [auth S], KA [auth a], T [auth J]	IPR056535	NUP160, middle TPR domain	Domain
B [auth 1], CA [auth S], KA [auth a], T [auth J]	IPR056536	NUP160, C-terminal TPR domain	Domain
C [auth 2], DA [auth T], LA [auth b], U [auth K]	IPR019775	WD40 repeat, conserved site	Conserved Site
C [auth 2], DA [auth T], LA [auth b], U [auth K]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
C [auth 2], DA [auth T], LA [auth b], U [auth K]	IPR037626	Nucleoporin Nup37	Family
C [auth 2], DA [auth T], LA [auth b], U [auth K]	IPR001680	WD40 repeat	Repeat
C [auth 2], DA [auth T], LA [auth b], U [auth K]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
D [auth 3], EA [auth U], M [auth C], V [auth L]	IPR037624	Nuclear pore complex protein Nup133-like	Family
D [auth 3], EA [auth U], M [auth C], V [auth L]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
D [auth 3], EA [auth U], M [auth C], V [auth L]	IPR007187	Nucleoporin, Nup133/Nup155-like, C-terminal	Domain
E [auth 4], FA [auth V], N [auth D], W [auth M]	IPR007252	Nuclear pore protein 84/107	Family
F [auth 5], GA [auth W], O [auth E], X [auth N]	IPR037665	Nucleoporin peptidase S59-like	Family
F [auth 5], GA [auth W], O [auth E], X [auth N]	IPR036903	Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain superfamily	Homologous Superfamily
F [auth 5], GA [auth W], O [auth E], X [auth N]	IPR007230	Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain	Domain
F [auth 5], GA [auth W], O [auth E], X [auth N]	IPR021967	Nuclear pore complex protein NUP96, C-terminal domain	Domain
G [auth 6], HA [auth X], P [auth F], Y [auth O]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
G [auth 6], HA [auth X], P [auth F], Y [auth O]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
G [auth 6], HA [auth X], P [auth F], Y [auth O]	IPR037363	Sec13/Seh1 family	Family
G [auth 6], HA [auth X], P [auth F], Y [auth O]	IPR001680	WD40 repeat	Repeat
H [auth 7], IA [auth Y], Q [auth G], Z [auth P]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
H [auth 7], IA [auth Y], Q [auth G], Z [auth P]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
H [auth 7], IA [auth Y], Q [auth G], Z [auth P]	IPR037363	Sec13/Seh1 family	Family
H [auth 7], IA [auth Y], Q [auth G], Z [auth P]	IPR001680	WD40 repeat	Repeat
H [auth 7], IA [auth Y], Q [auth G], Z [auth P]	IPR020472	G-protein beta WD-40 repeat	Repeat
AA [auth Q], I [auth 8], JA [auth Z], R [auth H]	IPR011502	Nucleoporin Nup85-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth 0], BA [auth R], J [auth 9], S [auth I]	Pharos: Q8NFH3	dermatomyositis medulloblastoma pancreatic ductal adenocarcinoma lung cancer osteosarcoma psoriasis malignant mesothelioma ovarian cancer testicular germ cell tumor
K [auth A], L [auth B]	Pharos: O75694	familial atrial fibrillation atrial fibrillation, familial, 15 adrenal cortex carcinoma large cell medulloblastoma malignant mesothelioma atrial fibrillation breast cancer lung cancer medulloblastoma atrial fibrillation, familial, 1 malignant colon neoplasm non-small cell lung carcinoma
B [auth 1], CA [auth S], KA [auth a], T [auth J]	Pharos: Q12769	adenoma endogenous depression large cell medulloblastoma malignant glioma osteosarcoma pilocytic astrocytoma astrocytic tumor glioblastoma lung cancer medulloblastoma ovarian cancer primitive neuroectodermal tumor atypical teratoid rhabdoid tumor hypertensive disorder malignant ependymoma adenoma endogenous depression large cell medulloblastoma malignant glioma osteosarcoma pilocytic astrocytoma astrocytic tumor glioblastoma lung cancer medulloblastoma ovarian cancer primitive neuroectodermal tumor atypical teratoid rhabdoid tumor hypertensive disorder malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm psoriasis
C [auth 2], DA [auth T], LA [auth b], U [auth K]	Pharos: Q8NFH4	acute myeloid leukemia glioblastoma lymphoplasmacytic lymphoma medulloblastoma oligodendroglioma pilocytic astrocytoma attention deficit hyperactivity disorder, inattentive type large cell medulloblastoma malignant ependymoma microcephaly ovarian cancer primitive neuroectodermal tumor atypical teratoid rhabdoid tumor lung cancer malignant glioma acute myeloid leukemia glioblastoma lymphoplasmacytic lymphoma medulloblastoma oligodendroglioma pilocytic astrocytoma attention deficit hyperactivity disorder, inattentive type large cell medulloblastoma malignant ependymoma microcephaly ovarian cancer primitive neuroectodermal tumor atypical teratoid rhabdoid tumor lung cancer malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm restless legs syndrome
D [auth 3], EA [auth U], M [auth C], V [auth L]	Pharos: Q8WUM0	dermatomyositis lung cancer osteosarcoma epilepsy Malignant neoplasm of breast ovarian cancer large cell medulloblastoma medulloblastoma
E [auth 4], FA [auth V], N [auth D], W [auth M]	Pharos: P57740	nephrotic syndrome, type 11 46 XX gonadal dysgenesis ovarian dysgenesis 6 Pure Gonadal Dysgenesis, 46, XX epilepsy intellectual disability lymphoplasmacytic lymphoma malignant glioma microcephaly oligodendroglioma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor Galloway-Mowat syndrome large cell medulloblastoma malignant colon neoplasm nephrotic syndrome, type 11 46 XX gonadal dysgenesis ovarian dysgenesis 6 Pure Gonadal Dysgenesis, 46, XX epilepsy intellectual disability lymphoplasmacytic lymphoma malignant glioma microcephaly oligodendroglioma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor Galloway-Mowat syndrome large cell medulloblastoma malignant colon neoplasm malignant mesothelioma nasopharyngeal carcinoma ovarian cancer progressive supranuclear palsy dermatomyositis glioblastoma lung cancer malignant ependymoma medulloblastoma
F [auth 5], GA [auth W], O [auth E], X [auth N]	Pharos: P52948	acute myeloid leukemia anemia lymphopenia neutropenia plasma cell myeloma glioblastoma large cell medulloblastoma medulloblastoma osteosarcoma sinusitis Acute Myeloid Leukemia (AML-M2) atypical teratoid rhabdoid tumor Hirschsprung disease, susceptibility to, 1 leukemia malignant mesothelioma acute myeloid leukemia anemia lymphopenia neutropenia plasma cell myeloma glioblastoma large cell medulloblastoma medulloblastoma osteosarcoma sinusitis Acute Myeloid Leukemia (AML-M2) atypical teratoid rhabdoid tumor Hirschsprung disease, susceptibility to, 1 leukemia malignant mesothelioma myopathy ovarian cancer tuberculosis cystic fibrosis invasive ductal breast carcinoma lung cancer
G [auth 6], HA [auth X], P [auth F], Y [auth O]	Pharos: P55735	autism spectrum disorder ovarian cancer craniolenticulosutural dysplasia glioblastoma
H [auth 7], IA [auth Y], Q [auth G], Z [auth P]	Pharos: Q96EE3	amyotrophic lateral sclerosis breast cancer lung cancer myopathy subependymal giant cell astrocytoma astrocytic tumor dermatomyositis lymphoplasmacytic lymphoma ovarian cancer atypical teratoid rhabdoid tumor large cell medulloblastoma malignant ependymoma rheumatoid arthritis
AA [auth Q], I [auth 8], JA [auth Z], R [auth H]	Pharos: Q9BW27	dermatomyositis medulloblastoma ovarian cancer systemic sclerosis gastric carcinoma non-alcoholic fatty liver disease Pick disease lung cancer osteosarcoma systemic lupus erythematosus