Download MendeleyOral single domain antibody inhibition of IL-23 signaling
Ota, N., Davies, C., Wallweber, H.A., Kiefer, J.R., Koerber, J.T.To be published.
9MDZ | pdb_00009mdz
anti-IL23R VHH
- PDB DOI: https://doi.org/10.2210/pdb9MDZ/pdb
- Classification: IMMUNE SYSTEM
- Organism(s): Lama glama
- Expression System: Cricetulus griseus
- Mutation(s): No
- Deposited: 2024-12-05 Released: 2025-05-21
- Funding Organization(s): Not funded
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.27 ?
- R-Value Free: 0.159 (Depositor), 0.158 (DCC)
- R-Value Work: 0.145 (Depositor), 0.145 (DCC)
- R-Value Observed: 0.145 (Depositor)
Starting Model: experimental
View more details
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| anti-IL23R VHH | A [auth E] | 120 | Lama glama | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GOL Query on GOL | B [auth E], C [auth E] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.27 ?
- R-Value Free: 0.159 (Depositor), 0.158 (DCC)
- R-Value Work: 0.145 (Depositor), 0.145 (DCC)
- R-Value Observed: 0.145 (Depositor)
Space Group: I 4 2 2
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 125.615 | ¦Á = 90 |
| b = 125.615 | ¦Â = 90 |
| c = 41.563 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| Aimless | data scaling |
| XDS | data reduction |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-05-21 Deposition Author(s): Kiefer, J.R., Koerber, J.T., Ota, N., Davies, C., Wallweber, H.A.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Not funded | -- |
Revision History (Full details and data files)
- Version 1.0: 2025-05-21
Type: Initial release
