Download Mendeleycitrate synthases complexed with oxaloacetate and acetyl-CoA
Yang, L.Y., Fang, Y.J.To be published.
8ZW1 | pdb_00008zw1
citrate synthases complexed with oxaloacetate and acetyl-CoA
- PDB DOI: https://doi.org/10.2210/pdb8ZW1/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2024-06-12 Released: 2025-06-18
- Funding Organization(s): National Natural Science Foundation of China (NSFC)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.10 ?
- R-Value Free: 0.299 (Depositor), 0.304 (DCC)
- R-Value Work: 0.233 (Depositor), 0.236 (DCC)
- R-Value Observed: 0.236 (Depositor)
Starting Model: experimental
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This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Citrate synthase, mitochondrial | 434 | Homo sapiens | Mutation(s): 0 Gene Names: CS EC: 2.3.3.1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for O75390 (Homo sapiens) Explore O75390 Go to UniProtKB: O75390 | |||||
PHAROS: O75390 GTEx: ENSG00000062485 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | O75390 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 4 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| ACO Query on ACO | F [auth B] | ACETYL COENZYME *A C23 H38 N7 O17 P3 S ZSLZBFCDCINBPY-ZSJPKINUSA-N |  | ||
| COA Query on COA | C [auth A] | COENZYME A C21 H36 N7 O16 P3 S RGJOEKWQDUBAIZ-IBOSZNHHSA-N |  | ||
| CIT Query on CIT | D [auth A] | CITRIC ACID C6 H8 O7 KRKNYBCHXYNGOX-UHFFFAOYSA-N |  | ||
| OAA Query on OAA | E [auth B] | OXALOACETATE ION C4 H3 O5 KHPXUQMNIQBQEV-UHFFFAOYSA-M |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.10 ?
- R-Value Free: 0.299 (Depositor), 0.304 (DCC)
- R-Value Work: 0.233 (Depositor), 0.236 (DCC)
- R-Value Observed: 0.236 (Depositor)
Space Group: P 1
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 57.523 | α = 102.52 |
| b = 59.789 | β = 98.23 |
| c = 72.582 | γ = 118.76 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| XDS | data reduction |
| XDS | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-06-18 Deposition Author(s): Yang, L.Y., Fang, Y.J.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Natural Science Foundation of China (NSFC) | China | -- |
Revision History (Full details and data files)
- Version 1.0: 2025-06-18
Type: Initial release
