Download MendeleyCrystal structure of the human PRPF4B in complex with Rebastinib
Godoi, P.H.C., Santiago, A.S., Ramos, P.Z., Silva, P.N.B., Righetto, G.L., Guimaraes, C.R.W., Massirer, K.B., Arruda, P., Elkins, J.M., Edwards, A.M.To be published.
6CNH | pdb_00006cnh
Human PRPF4B in complex with Rebastinib
- PDB DOI: https://doi.org/10.2210/pdb6CNH/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Spodoptera frugiperda
- Mutation(s): No
- Deposited: 2018-03-08 Released: 2018-03-28
- Funding Organization(s): Sao Paulo Research Foundation (FAPESP)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 ?
- R-Value Free: 0.206 (Depositor), 0.210 (DCC)
- R-Value Work: 0.182 (Depositor), 0.190 (DCC)
- R-Value Observed: 0.183 (Depositor)
Starting Model: experimental
View more details
This is version 1.3 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Serine/threonine-protein kinase PRP4 homolog | 351 | Homo sapiens | Mutation(s): 0 Gene Names: PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K EC: 2.7.11.1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q13523 (Homo sapiens) Explore Q13523 Go to UniProtKB: Q13523 | |||||
PHAROS: Q13523 GTEx: ENSG00000112739 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q13523 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 919 Query on 919 | B [auth A] | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide C30 H28 F N7 O3 WVXNSAVVKYZVOE-UHFFFAOYSA-N |  | ||
| SO4 Query on SO4 | C [auth A], D [auth A], E [auth A], F [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 ?
- R-Value Free: 0.206 (Depositor), 0.210 (DCC)
- R-Value Work: 0.182 (Depositor), 0.190 (DCC)
- R-Value Observed: 0.183 (Depositor)
Space Group: C 1 2 1
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 85.169 | α = 90 |
| b = 75.661 | β = 92.82 |
| c = 68.075 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| XDS | data reduction |
| Aimless | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2018-03-28 Deposition Author(s): Godoi, P.H.C., Santiago, A.S., Ramos, P.Z., Fala, A.M., Salmazo, A.P.T., Counago, R.M., Righetto, G.L., Silva, P.N.B., Gileadi, O., Guimaraes, C.R.W., Massirer, K.B., Arruda, P., Elkins, J.M., Edwards, A.M., Structural Genomics Consortium (SGC)
| Funding Organization | Location | Grant Number |
|---|---|---|
| Sao Paulo Research Foundation (FAPESP) | Brazil | 13/50724-5 |
Revision History (Full details and data files)
- Version 1.0: 2018-03-28
Type: Initial release - Version 1.1: 2019-04-17
Changes: Author supporting evidence, Data collection - Version 1.2: 2020-01-01
Changes: Author supporting evidence - Version 1.3: 2023-10-04
Changes: Data collection, Database references, Refinement description
