LYS

LYSINE

Created:	1999-07-08
Last modified:	2024-09-27

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189 entries where LYS is found as a standalone ligand67 entries where LYS is covalently linked to polymer or other heterogen groups 229,746 entries where LYS is found in a polymer sequence

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Chemical Details
Formal Charge	1
Atom Count	25
Chiral Atom Count	1
Bond Count	24
Aromatic Bond Count	0

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Chemical Component Summary
Name	LYSINE
Systematic Name (OpenEye OEToolkits)	[(5S)-5-amino-6-hydroxy-6-oxo-hexyl]azanium
Formula	C₆ H₁₅ N₂ O₂
Molecular Weight	147.195
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CCCC[NH3+]
SMILES	CACTVS	3.341	N[CH](CCCC[NH3+])C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])CC(C(=O)O)N
Canonical SMILES	CACTVS	3.341	N[C@@H](CCCC[NH3+])C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])C[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKey	InChI	1.03	KDXKERNSBIXSRK-YFKPBYRVSA-O

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00123 ?
Name	Lysine
Groups	approved nutraceutical
Description	Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Synonyms	L-2,6-Diaminocaproic acid Lysine Lysine acetate (S)-α,ε-diaminocaproic acid LYS Lysine acid (S)-lysine Lysine hydrochloride Lysinum L-Lysine L-lys Lysine monohydrate 6-ammonio-L-norleucine Lysine dihydrate (S)-2,6-diaminohexanoic acid L-Lysin Lysina
Brand Names	Aminosyn 8.5% Injection With Electrolytes RenAmin Aminosyn RF Aminosyn 7% 20% Prosol HepatAmine Nutrineal Pd4 Primene 10% 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn-PF 7% Xyzmune Aminosyn II 7% Injection Novamine 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Aminosyn II 7% M In 10% Dextrose(dual Chamber) Smofkabiven Extra Nitrogen Electrolyte Free Olimel 7.6% Aminosyn HF Aminosyn II 7% With 50% Dextrose Clinisol NephrAmine Aminosyn II 8.5% Injection Aminosyn II 7% With 10% Dextrose 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Smofkabiven Electrolyte Free Aminosyn II 10% With Electrolytes TrophAmine Olimel 4.4% E Periolimel 2.5% E 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Primene 10%-liq IV Lysakare Smofkabiven Peripheral Imubolic Travasol Inj Without Electrolytes 5.5% Olimel 5.7% E ProSol Aminosyn 8.5% Olimel 5.7% Aminosyn 10% W Electrolytes Kabiven 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Aminosyn II In Dextrose Injection 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Essepna Olimel 3.3% E Plenamine Travasol Inj Without Electrolytes 8.5% 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn RF Injection Effervescent Potassium Chloride 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn Aminosyn II and Dextrose Travasol Aminosyn-PF 10% Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Synthamin 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 8.5% Freamine III Aminosyn II in Dextrose Aminosyn II 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn Sulfite Free Aminosyn II with Electrolytes in Dextrose with Calcium Hepatasol Aminosyn-PF Perikabiven 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Nephramine Liq IV Aminosyn 5% Olimel 4.4% 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Premasol - sulfite-free (Amino Acid) Aminosyn II with Electrolytes Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Aminosyn 3.5% M Olimel 7.6% E 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Vamin 18 Electrolyte-free FreAmine III Aminosyn II 8.5% With 50% Dextrose Travasol Amino Acid Inj 5.5% Smofkabiven Extra Nitrogen 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Renamin (amino Acids) Injection Vamin N Clinimix Primene Travasol Amino Acid Inj 8.5% 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Smofkabiven 4.25%travasol Amino Acid InJ.W.elecw.5%dex. 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix FreAmine HBC ProcalAmine Travasol E Clinimix E Aminosyn II 5% Inj
Indication	Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Categories	Amino Acids Amino Acids, Basic Amino Acids, Diamino Amino Acids, Essential Amino Acids, Peptides, and Proteins Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Detoxifying Agents for Antineoplastic Treatment Dietary Supplements I.V. Solution Additives Lysine Proteinogenic Amino Acids Supplements
ATC-Code	V03AF11 B05XB03
CAS number	56-87-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
High affinity cationic amino acid transporter 1	MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 4	MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGM...	unknown
Cationic amino acid transporter 3	MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 2	MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGA...	unknown
Lysine--tRNA ligase	MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQ...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682