VIV

(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL

Created:	2003-11-04
Last modified:	2011-06-04

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9 entries where VIV is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	81
Chiral Atom Count	3
Bond Count	82
Aromatic Bond Count	6

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Chemical Component Summary
Name	(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
Systematic Name (OpenEye OEToolkits)	(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
Formula	C₂₉ H₅₀ O₂
Molecular Weight	430.706
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Oc2c(c(c1OC(CCc1c2C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)C
SMILES	CACTVS	3.341	CC(C)CCC[CH](C)CCC[CH](C)CCC[C]1(C)CCc2c(C)c(O)c(C)c(C)c2O1
SMILES	OpenEye OEToolkits	1.5.0	Cc1c(c2c(c(c1O)C)CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C
Canonical SMILES	CACTVS	3.341	CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1
Canonical SMILES	OpenEye OEToolkits	1.5.0	Cc1c(c2c(c(c1O)C)CC[C@@](O2)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C
InChI	InChI	1.03	InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
InChIKey	InChI	1.03	GVJHHUAWPYXKBD-IEOSBIPESA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00163 ?
Name	Vitamin E
Groups	approved nutraceutical vet_approved
Description	In 1922, vitamin E was demonstrated to be an essential nutrient[A32448]. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active[A176104]. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage[A176104]. The antioxidant effects are currently being researched for use in the treatment of diseases causing bone loss, cardiovascular diseases, diabetes mellitus and associated comorbidities, eye diseases, inflammatory diseases (including skin conditions), lipid disorders, neurological diseases, and radiation damage[A176369]. Though this research is so far inconclusive, vitamin E remains a popular supplement and is generally considered safe by the FDA[FDA Label].
Synonyms	(R,R,R)-α-tocopherol Vitamin E alpha-tocopherol 5,7,8-trimethyltocol (+)-α-tocopherol d-α-tocopherol (2R,4'R,8'R)-α-tocopherol
Brand Names	Vitamin E Ont 30unit/gm Poly-VI-flor RE FAC-x Vitaphil 90 DHA Viprot Iron Complex Stretch Mark Cream Vitamin E Capsules 800iu Vitamin D3 Dietary Supplement Cream Multi Enfants Tab Formula Cw-caplet PreNexa premier E 100 Iu Capsules TriStart FREE Evening Primrose Oil Cap Real Vitamin Supplement Cap Vitamin E With Selenium and Zinc Gnc Natural Source Ultra E 400 - Cap Vitamin E Ointment 50unit/gm Vitamine E 400iu Cap One Tablet Daily Mens Formula Sveets Swiss One Multi Vit & Chel Min Tab Twin Opti Pwr Vitamin E Cap USP 1000unit Acti-D Alphacopherol Cap 800unit Geri-plus Cap Mlc Premium Prenatal Now E-400 Multivitamins and Minerals for Young Men Vitamin E 30unit Ont Natural E 400iu W Selenium 100mcg Kimchi Vitamin chewable multivitamin Bio-efa Borage Gla 240 Cap VitaPhil Aide One A Day Advance Adults 50+ Vitamin E Cap 400unit USP Nat Source Hoa 1 Tendera-OB Vitamin E Ont Vitamin E 400 I.U. Cap C.V. Formula TL-Care DHA Webber Vitamin E Cap 400unit Natural Source Vitaphil DHA Cellular Formula Multi 12 Injection Efamol Cap Vit E 400unit W Selenium 50mcg Vitamine E 800 Ui Naturelle -cap Vitamin E 400 + Selenium Cap E Vitamin 1000 I.U. (natural Source) Usana Megavitamin Tablets - Tab VITAFOL Gummies Healing Ointment With Vitamin E Triveen-PRx RNF Formula Cw E 200 Cap Natural 200unit Vitamin E Cap 100unit USP Natural Source Vitamin E Cap 200unit FolaGent DHA Tozal Thera Q Plus Selenium 200mcg Plus C & E Tab Card-floe II Tab Beta-CE Cap Z-force Vitamin and Mineral Supplement Vyqua Vitamin E 200 I.U. (natural Source) OB Complete 400 Pro-gla Caps Vitafol OB Caplet WesNate DHA Prenatal Mega Antioxidant 24 Multivitamins + Minerals Vie-CA-rad Capsules Diacomp - Cap Relnate DHA Vitamin and Mineral Supp Formula 1 For-2 Maltlevol Liq Multi Flow Tablets Bye Bye Burn Lot Multi 1000 Tianshi Calcium With Natural Source Vitamin E Softgel Capsules Vege Swiss One Multivitamin W Chel Mins Tab Multi Vitamines - Liq Animal Shapes RE Prenatal Multivitamin with Iron Women's Biomultiple Vitamin and Mineral Supplement Vitamine E 100ui Capsule Bio-efa Borage Gla 90 Cap Nutra Boost Totalvit Plus Liqui Vita Belly Butter Stretch Marks Cream Multivitamins W Minerals Extra Strength Vitamin E 1000iu Multi-force for Adults Tab Vp-pnv-dha Organex E 400 Stress Tab With Iron and Vitamin E Phytomin E Cap 800unit Floriva Plus Vitafol Caplet VITAMIN D3 1.25 MG 50000 IU Dietary Supplement Cavan Prenatal Hyper E Tab Ultimate Tab Vimeral Tab Multinate DHA Natural Source Vitamine E Capsules Mega Plex IV - Pck Virt-Pn DHA Nexa Select Rx Prenatal Vitamin with Plant-Based DHA Vitamines Et Mineraux Enfants 970 Sopalamine 3b Plus Vitamin E 400 Iu and Selenium 100mcg Rulavite DHA Vitamin E 400 Iu - Capsule Tricare Prenatal DHA One TL-Select DHA Vitamin E U.S.P. 200 I.U. - Cap NovaFerrum Multivitamin with Iron Pediatric Drops Vitamin E Ont 1000unit Aces Formula/formule A A S Vitamin E Pure 800 I.U. Vitamin E Cap 800 Unit Natural Organex E 800 Swiss One Multivitamin and Mineral Caplet Synergistic Selenium Aces Caplet Poly-Vi-Flor Gummies Formula F L W Formula F.E.S. Vitamins Tab NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA PNV-Omega Vitamine E Creme 250unit/ml Renate Multi-vitamines Enfants Comprime PreFol-DHA Virt-PN Plus Natural Source Vitamin E 400 Iu Vitamin E Cap 400unit Natural Source Prenatal Sincera - Tablets Sopalamine/3b Plus C Vege 1 Daily Tab Super Vita-vim With Beta-carotene - Tab Super Kids Chewable Multivitamin Multimineral (chewable Tablets) E 100 Cap Natural 100unit Strovite Forte Caplet Adeks - Dps Vitamin E Cap 200iu Nf Natural Source TL-Select TL-Fluorivite E 400 Iu Hypo Vites Tab Taron-prex Prenatal Vitafol One Prenate Essential TriStart ONE C-Nate DHA Cedevita Sugar-free Vitamin Supplement Webber Vitamin E Cap 400unit Original E-gems-M Inner Health Vitamin Supplement Capsules Stress Tab With Zinc, Copper and Vitamin E Vitafol Plus Senior Multi One Rogenic Original Bioscal Forte Multi-vitamin Supplement Capsules Spark Cap Floriva Longevit-E - Capsule Homosistrox Capsules Leritone Antistress E 200 Cap 200unit MultiVitamin with Fluoride Drops Nutrol E 200 Cap Nutrol E-400 Plus Zinc Et Selenium Cap Extra-Virt Plus DHA Se-Plete DHA Coenzyme Q10 + Vitamin E 200 I.U. Cap Multivitamin with Fluoride Maxum Multi-vite Classic Swiss One 10 Multivitamin and Mineral Tab Prost-10 Vitamin and Mineral Supplement Selenium Plus C & E Liqui-E 27 Units/ml Vitamine E Cap 100unit Vitamine E 200 U.I. Vitaplex P-plus Vitamin E Capsules 200unit Vitamine E 400 U.I. Beta A With Vitamins C and E Plus Selenium Evening Primrose Oil With Vitamin E Vitamine E Cap 100iu Adrien Gagnon Formule A-C-E + Selenium Mr. Tumee Multi-vitamin Beta-carotene 10,000 Iu With Vitamins C & E Vitamin E Cap USP 100iu Children's Chewable Multivitamin and Multimineral Poly-Vi-Sol Co-q10 M.R.B. 100mg and Vitamin E O-Cal FA multivitamin Florravite Niron Komplete Vitamin E Cap USP 200iu RE Nata Liquical Acne C-Patch M.V.I. Paediatric Virt-Pn Childrens Multiple Vit and Min Chew Tab Co-q10 M.R.B. 60mg Food Nutrition Inc. Men's Vitamin and Mineral Supplement Natural Source Spectrum With Beta Carotene Natural Source Vitamin E 1000 Iu Beta-carotene,vitamin C,e and Selenium Combo Multi II IV Vi Tab Prenaissance Vol-Plus WesCap-PN DHA Vitamin E Cap 1000unit USP Natural Source Am Caps Selenium + E Vitamin E Capsules USP 400 I.U. Formula Hh Vitamin E Capsules 400iu Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Multinate DHA Extra Calcium PNV Super Gardialine Cap 100iu Femitab Tab Formula-4 Sx Pro E Cap 200unit A.C.E.S. Capsules Childrens Chew Multi Vitamin Tab Nutria H.W. Children's Chewable Multi Vit & Mineral Multivitamins and Minerals for Young Women Cell-wise Natural Source Super Charged Energy Ferulic Acid CE Skin Serum Hi Potency Multi Tab Daily Supplement Packs Children's Chewable Vit and Min Tab RE Nata OB Multi-force for Women Tab Vitamin E Cap 50unit Mycelized Childrens Multi-vitamin Liq Multi-Vitamin PreGen DHA Vita-E Webber Vitamin E Cap 800unit Original Acti-D Alphacopherol Cap 400unit VemaVite-PRx 2 with Fish-Based DHA Kanga-V Multivitamins & Minerals Evening Primrose Oil + Vit E Cap Adeks Tablets Vitamin E Cap 200unit USP Natural Source Multi Vitamin, Iron and Fluoride NovaDHA Baby DHA 50 Plus Vitamin E Plus Cap 200units Liqui Infant Vitamins Virt-Nate DHA Mega Vitaminerals Virt-Select PRENATAL/POSTNATAL Vitamin E Cap 1000unit Vitamine E Cap USP 800unit Vitamin E Cap 200iu Zatean-Pn DHA Phytomin E Cap 200unit Extra 11 One A Day Multiple Vit W Minerals Multi Plex II - Tab Cedevita Plus Vitamin Supplement Leritone Magnesium & Vitamine E Vitamin E 200 Iu Capsules Vitamin E 400 I.U. (natural Source) Fem Time Tab L-Methyl PNV DHA Twin G.F. Powder OB Complete DHA Q-10 Extra -cap Re Ob 90 DHA Selenium '100' Plus C&e Selenion Mangadyn Super Ao Formula Black Currant Seed Oil Cap Bear Essentials Tricare Prenatal DHA One Rx Multivitamin Tricare Prenatal DHA One With Folate Nitro Vites - Tab Vitamine E 100cap Aces Tab Vitamune Multivitamin with 0.25 mg Fluoride CitraNatal Assure Maltlevol 12 Liq Vitamin E 400iu Chewable Multiple Vitamins Plus Extra C Kindervites PreNexa Liquid Vitamin E Multipack II Vitamin E Cap 100unit Mycellized Vit E Liq 150unit/ml Avengers Vitamin and Mineral Supplement Multivitamins and Minerals for Men Onccor Vitamin E Cap 400unit Dr. Waltons Baby Powder Multicaps Multitabs Vitamin E 1000 Iu - Water Soluble Ch-P Cap Organex E 100 CitraNatal Harmony 3.0 Vitamin E Cap USP Nat Ratio 200unit Emuol V Vitamin E 1000 I.U. (natural Source) Vasula Tab Avon Nutrivance Vitamin E Plus Nexa Plus Virt-PN DHA Coq10 With E400 Iu Mega Plex III - Pck Vitamin E 100 Iu Natural Source Vitamine E 800 I.U. Collag-EN Multivit with Fluoride Great Day/am Formula Tab OB Complete Gold Liquid Manganese 50mg Plus B1 & E Tab Huile D'onagre Vitamin E Vitamin E 25 Iu Thuna's Vitamin E Acetate Cap 800t Daily Energy Brand Vitamin & Mineral Drink Mix Multi Plex I - Tab Natural Source Vitamin E 800 Iu PreQue 10 Vitamin E Cap USP 400unit Evening Primrose Oil Cap 500mg W Vit E Doctor's Choice Brand for Men Vitamin E Cap 400iu Multi-Nate 30 Nutra-clear Vitafol Fe Plus Vista Advanced AREDS2 Formula Folivane-PRx DHA Vital Be-100 Vitamine E Cap 200unit Vitalife - Capsule Reaphirm Plant Source DHA Vita-vim - Tab MultiVitamin, Iron and Fluoride Drops Natural Source Vitamin E CitraNatal Medley Vitamin E Cap 800unit Cps Capsules Olympian Vit E Cap 400unit Multi Vitamin and Fluoride Natelle One Twin G.F. Powder Vanilla Flavor FolaMed DHA Vitafol-OB Plus DHA Prenatal Supplement Plus DHA CitraNatal Essence Vitamin E Cap 800unit USP Complete One-A-day - Tab Vitamin E Caps USP 200unit Enrich Core Pack - Children Vitamin and Mineral Supplement Vitamin E Capsules U.S.P. 400 I.U. Gamma Oil Extra Once A Day Keylosa Multi-Vit-Flor Protect Plus SO 60 Multiple Vitamins Tab Vitamin E 200iu Chewable E 100 Iu Vitamine E Cap 400unit NovaMV Multivitamin Swiss One Timed Release Tab Cavan-EC SOD DHA Tma Tab Silexin Vitamine E 100 I.U. VirtPrex Udamin Sp Dr. Chen's Men's Formula Omega-3 Rx Complete Luna Vitamin and Mineral Bar for Women Gnc Natural Source Ultra E 1000 - Cap PM Caps Vitamin E 200iu Thuna's Earthpals Children's Chewables Multi-vitamin & Mineral Tablets Vitamin E 400 Iu USP E-400 Cap 400unit Anti Fatigue Eye Drops Multiple Vit Plus Iron Tab Women's Change Formula Vitamin E Cap 1000iu Vitaminol Multi Spectrum - Tablet Maxine Vitamin and Mineral Supplement Multivitamin with 1.0 mg Fluoride Vita-vim With Beta-carotene - Tab Vision E - 134iu/cap Multivitamins and Minerals With Betacarotene Tablets Vitamin E Cream W Vitamins A and D Fem - Protect Revitalize Multi-vitamin and Mineral Complex Vitamin E Cap 800iunf Natural Vitamin E 400 Iu Cell-wise Multi Tabs Multivitamins and Minerals for Women Vitamine E Caps 800unit USP Maintain Multiple Vitamin & Minerals Swical-energy 3e Age Vitamin E 800 I.U. Folet One E-prime Vitamin E Supplement Men's Biomultiple Vitamin and Mineral Supplement Vl Micel E Liq 100unit/ml natelle COMPLETE Reliv So Sense Daily Vitamin Supplement Childrens Chewable Tab Vitamin E and Coq10 Dandruff Cleanser Multivitamin and Mineral Nata Komplete Nexa Select Prenate Elite Vitamine E 200 Cap Supplements De Vitamines Et Mineraux Multiple Vitamins and Minerals Capsules Poly-Vi-Flor Swiss One Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA Multi-kid Renate DHA Vitamin E Cap 200unit Natural Source Zatean-Pn Plus Vitamine E Capsules 25ui Multi #2 Vitamines Et Mineraux Comprimes antistressSAN Feminex 300 Tab Multiple Vitamins Plus Iron Tab Acti-copherols 200 Cap Vitamin E Vitamin E 400 Iu Capsules Vitamin E 400unit Cap Prenatal Vi-min Vita Balance 2000 Advanced AM PM Vitamine E25vi Capsule Vitamines Et Mineraux MVC-Fluoride Rocky Mountain Multiple Vit and Min Mega Tab Complete One A Day Tab
Indication	Vitamin E supplementation is indicated for treatment of vitamin E deficiency which can occur in cystic fibrosis, cholestasis and severe liver disease, abetalipoproteinemia or simply poor diet[A176104,L3063].
Categories	Antioxidants Basic Ointments and Protectants Benzopyrans Biological Factors Compounds used in a research, industrial, or household setting Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Diet, Food, and Nutrition Dietary Supplements Food Growth Substances Heterocyclic Compounds, Fused-Ring Micronutrients Physiological Phenomena Protective Agents Pyrans Supplements Vitamin E Vitamin E, analogs & derivatives Vitamins Vitamins (Fat Soluble)
CAS number	59-02-9

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
SEC14-like protein 4	MSSRVGDLSPQQQEALARFRENLQDLLPILPNADDYFLLRWLRARNFDLQ...	unknown
SEC14-like protein 3	MSGRVGDLSPKQAETLAKFRENVQDVLPALPNPDDYFLLRWLRARNFDLQ...	unknown
SEC14-like protein 2	MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQ...	unknown
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown
Protein kinase C beta type	MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFC...	unknown
Polyunsaturated fatty acid 5-lipoxygenase	MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGA...	unknown
Protein kinase C alpha type	MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFC...	unknown
Diacylglycerol kinase alpha	MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGY...	unknown
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRC...	unknown
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRC...	unknown
Glutathione S-transferase P	MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLY...	unknown	inhibitor
Glutathione S-transferase omega-1	MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHE...	unknown	inhibitor
Glutathione S-transferase Mu 3	MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQW...	unknown	inducer
Glutamate--cysteine ligase catalytic subunit	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDE...	unknown	inducer
NAD(P)H dehydrogenase [quinone] 1	MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPI...	unknown	inducer
Heme oxygenase 1	MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLV...	unknown	inducer
Superoxide dismutase [Cu-Zn]	MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHE...	unknown	inducer
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inducer
Glutathione S-transferase A2	MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYL...	unknown	inducer
SEC14-like protein 2	MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQ...	unknown	binder
SEC14-like protein 3	MSGRVGDLSPKQAETLAKFRENVQDVLPALPNPDDYFLLRWLRARNFDLQ...	unknown	binder
Phospholipid transfer protein	MALFGALFLALLAGAHAEFPGCKIRVTSKALELVKQEGLRFLEQELETIT...	unknown	binder
Alpha-tocopherol transfer protein	MAEARSQPSAGPQLNALPDHSPLLQPGLAALRRRAREAGVPLAPLPLTDS...	unknown	binder
Scavenger receptor class B member 1	MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSS...	unknown	substrate
Phospholipid-transporting ATPase ABCA1	MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYE...	unknown	substrate
NPC1-like intracellular cholesterol transporter 1	MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLM...	unknown	substrate
ATP-binding cassette sub-family G member 1	MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLN...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682