HCZ

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Created:	2009-08-06
Last modified:	2011-06-04

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4 entries where HCZ is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	25
Chiral Atom Count	0
Bond Count	26
Aromatic Bond Count	6

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Chemical Component Summary
Name	6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Systematic Name (OpenEye OEToolkits)	6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
Formula	C₇ H₈ Cl N₃ O₄ S₂
Molecular Weight	297.739
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	11.02	O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)NCN2)N
SMILES	CACTVS	3.352	N[S](=O)(=O)c1cc2c(NCN[S]2(=O)=O)cc1Cl
SMILES	OpenEye OEToolkits	1.7.0	c1c2c(cc(c1Cl)S(=O)(=O)N)S(=O)(=O)NCN2
Canonical SMILES	CACTVS	3.352	N[S](=O)(=O)c1cc2c(NCN[S]2(=O)=O)cc1Cl
Canonical SMILES	OpenEye OEToolkits	1.7.0	c1c2c(cc(c1Cl)S(=O)(=O)N)S(=O)(=O)NCN2
InChI	InChI	1.03	InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
InChIKey	InChI	1.03	JZUFKLXOESDKRF-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00999 ?
Name	Hydrochlorothiazide
Groups	approved vet_approved
Description	Hydrochlorothiazide is the most commonly prescribed thiazide diuretic.[A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.[A185138] Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459] Hydrochlorothiazide was granted FDA approval on 12 February 1959.[L8444]
Synonyms	Hydrochlorothiazidum Hidroclorotiazida HCTZ Hydrochlorothiazide
Brand Names	Auro-quinapril Hctz Tolucombi Aldactazide 25 Teva-triamterene/hctz Teva-valsartan/hctz Amlodipine, Valsartan and Hydrochlorothiazide Jamp-irbesartan and Hydrochlorothiazide Act Candesartan/hct Ntp-lisinopril/hctz (type Z) Enalapril maleate and hydrochlorothiazide TELMISARTAN and HYDROCHLOROTHIAZIDE Mint-losartan/hctz Lisinopril with Hydrochlorothiazide Valsartan HCT Vaseretic Dyazide OLMESARTAN MEDOXOMIL and HYDROCHLOROTHIAZIDE Aldactazide PMS-hydrochlorothiazide Teva-spironolactone/hctz Auro-irbesartan HCT Lotensin HCT Nra-olmesartan Hctz Teva-lisinopril/hctz (type Z) Jamp-losartan Hctz PMS-candesartan-hctz Bisoprolol Fumarate Hydrochlorothiazide Apo-hydrochlorothiazide Amlodipine, Valsartan, Hydrochlorothiazide Inderide-80 Tab Ava-hydrochlorothiazide Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/10/25 mg Aa-amilzide Hydrochlorothiazide Tablets 50mg Novo-doparil 25 Tab Mylan-losartan Hctz Auro-olmesartan Hctz Ag-irbesartan Hctz PMS-valsartan-hctz Benazepril and Hydrochlorothiazide Apo-losartan/hctz Teva-enalapril/hctz Sandoz Losartan HCT DS Metoprolol Tartrate and Hydrochlorothiazide 100 mg-25 mg Auro-losartan HCT Triamterene hydrochlorothiazide Hydralazine HCl and Hydrochlorothiazide Act Irbesartan/hct Hydrochlorothiazide Tab 25mg Ag Telmisartan-hct Quinapril Hydrochloride/hydrochlorothiazide Methyldopa and Hydrochlorothiazide Lisnopril/hctz (type P) PMS-irbesartan-hctz Teva-candesartan/hctz Losartan/hct Bisoprolol Fumarate and Hydrochlorothiazide Ratio-losartan Hctz Metoprolol Tartrate and Hydrochlorothiazide Sandoz Candesartan Plus Telmisartan Hctz Imprida HCT PMS-ramipril-hctz LOSARTAN POTASSIUM and HYDROCHLOROTHIAZIDE Hydrochlorothiazide Tablets 25mg Enalapril Maleate/hctz Teva-ramipril/hctz Van-irbesartan-hctz PHL-hydrochlorothiazide Lisinopril/HCTZ Jamp Telmisartan-hct Teva-telmisartan Hctz Uniretic Quinapril and Hydrochlorothiazide 20/25 Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/25 mg Micardis Plus Irbesartan/hct Dyazide Tab Ser-AP-ES Tab Sandoz Olmesartan Hctz Teva-lisinopril/hctz (type P) Mint-irbesartan/hctz Apo Methazide 15 Candesartan Cilexetil and Hydrochlorothiazide Tablets Apo Triazide Jamp Quinapril / Hctz Olmesartan Medoxomil/hctz Hydrochlorothiazide Tab 50mg Teva-losartan/hctz Gd-quinapril Hctz Losartan Pot/hctz Losartan HCT DS Hydrochlorothiazide 50mg Tablets Valsartan and Hydrochlorothiazide Ramipril-hctz Accuretic Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide Metoprolol Tartrate and Hydrochlorothiazide 100 mg-50 mg Olmesartan Medoxmil and Hydrochlorothiazide Amiloride Hydrochloride and Hydrochlorothiazide Bio-hydrochlorothiazide Olmesartan Medoxomil-hydrochlorothiazide Teva-olmesartan/hctz Hyzaar Apo-irbesartan/hctz Irbesartan and Hydrochlorothiazide Olmetec Plus Apo-candesartan/hctz Urozide Quinapril Hydrochloride and Hydrochlorothiazide Valsartan and hydrochlorothiazide Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/12.5 mg Mar-candesartan / Hctz Hydrochlorothiazide 25mg Tablets Rasilez HCT Capozide Hydrochlorothiazide 100 Tab Teva-irbesartan/hctz Apo-valsartan/hctz Ava-valsartan HCT Nra-candesartan Hctz PMS-dopazide 15 Tab Monopril-hct Sandoz Valsartan HCT Apo-quinapril / Hctz Tablets Hydrochlorothiazide 100mg Tablets Fosinopril Sodium and Hydrochlorothiazide Mint-hydrochlorothiazide Novo-valsartan/hctz Benazepril hydrochloride and hydrochlorothiazide Captopril and Hydrochlorothiazide Penta-triamterene Hctz Tablets Micardisplus Irbesartan / Hydrochlorothiazide Teva Ach-olmesartan Hctz Jamp-olmesartan Hctz Ifirmacombi Auro-candesartan HCT Sandoz Irbesartan HCT Exforge HCT Telmisartan/hctz Nu-amilzide 5/50 Mg Tab Benazepril Hydrochloride and Hydrochlorothiazide Losartan HCT Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide Ach-telmisartan Hctz Metoprolol Tartrate and Hydrochlorothiazide 50 mg-25 mg Atacand Plus Jamp Candesartan-hct Apo-quinapril/hctz Candesartan Cilexetil-Hydrochlorothiazide Zestoretic Ntp-irbesartan/hctz Nu-hydro Avalide Lisinopril and hydrochlorothiazide Moexipril hydrochloride/hydrochlorothiazide Auro-valsartan HCT Irbesartan Hydrochlorothiazide Bms Ava-irbesartan/hctz Hydropres 50 Tab Neo Codema 50mg Timolide Tab PMS-olmesartan-hctz Ag-losartan Hctz Tekturna HCT Losartan potassium and Hydrochlorothiazide Mylan-candesartan Hctz Kinzalkomb Apo Methazide 25 Ziac Benicar HCT Hyzaar DS Irbesartan Hydrochlorothiazide Zentiva Microzide Mylan-irbesartan Hctz Ntp-lisinopril/hctz (type P) Amturnide Benicar Hct Candesartan Cilexetil and Hydrochlorothiazide Enalapril/hctz Teva-irbesartan Hctz Tribenzor Telmisartan and Hydrochlorothiazide Ami-hydro Tab Aldactazide 50 Apo-olmesartan/hctz Amlodipine, Valsartan, and Hydrochlorothiazide Losartan potassium and hydrochlorothiazide Septa-candesartan Hctz Valsartan-hctz Ran-irbesartan Hctz Ag-candesartan HCT Nra-telmisartan/hctz Apo-telmisartan/hctz Ava-lisinopril HCT Maxzide Teva-hydrochlorothiazide Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/10/12.5 mg Olmesartan Medoxomil and Hydrochlorothiazide Sandoz Losartan HCT Inhibace Plus Lisinopril and Hydrochlorothiazide Apo-lisinopril/hctz Teva-quinapril/hctz Coaprovel Septa-losartan Hctz Act Telmisartan/hct Sandoz Telmisartan HCT Diovan HCT Riva-amilzide 5/50 mg Inderide-40 Tab Aldoril 15 Tab Atacand HCT Propranolol Hydrochloride and Hydrochlorothiazide Apo-ramipril/hctz Copalia HCT Valsartan HCTZ Hydrodiuril Tab 25mg Actelsar HCT Prz-olmesartan/hctz Ag-olmesartan Hctz Lisinopril/hctz (type Z) Viskazide Diuchlor H Tab 50mg Losartan Potassium HCTZ Irbesartan/hydrochlorothiazide Teva Mylan-telmisartan Hctz Mylan-lisinopril Hctz Neo Codema 25mg Quinapril Hydrochloride/Hydrochlorothiazide Accel-candesartan/hctz Auro-telmisartan Hctz Pendo-telmisartan-hctz Riva-zide 50/25mg Tablets Aldoril Mylan-amilazide Hydrochlorothiazide 50 Hydrodiuril Tab 100mg Pendo-irbesartan-hctz Lopressor HCT Telmisartan and Hydrochlorthiazide Candesartan HCT Olmesartan/hctz Losartan-hctz Van-telmisartan-hctz Dafiro HCT Irbesartan HCT Ser-Ap-Es Dom-hydrochlorothiazide Maxzide-25 Pro-triazide Q-valsartan Hctz Quinaretic Altace HCT Aldoril 25 Tab Teveten HCT Teva-cilazapril/hctz Quinapril HCL and Hydrochlorothiazide Sandoz Lisinopril HCT Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg Taro-ramipril Hctz Alti-amiloride Hctz Van-losartan-hctz Telmisartan-hctz Micardis HCT Ntp-hydrochlorothiazide Moduret Diovan-hct Losartan Potassium and Hydrochlorothiazide Candesartan-hctz Nu-lisinopril/hctz Triamterene and Hydrochlorothiazide Olmesartan Medoxomil / Hydrochlorothiazide Penta-amiloride Hctz Tablets Mint-losartan/hctz DS Esidrix Novo-doparil 15 Tab Truemed Group LLC Quinapril and Hydrochlorothiazide 10/12.5 Irbesartan-hctz Ntp-telmisartan Hctz Gln-olmesartan Hctz Teva-olmesartan / Hctz Irbesartan/hctz Taro-telmisartan Hctz Quinapril and Hydrochlorothiazide 20/12.5 Quinapril and Hydrochlorothiazide Novamilor Enalapril Maleate and Hydrochlorothiazide Lisinopril and Hydrochlorthiazide Candesartan/hctz Hydrodiuril Tab 50mg Pritorplus Act Losartan/hct Dutoprol Hydropres 25 Tab PMS-telmisartan-hctz Apo-cilazapril/hctz Dom-irbesartan-hctz Inderide Apo-spirozide Tab Moexipril Hydrochloride and Hydrochlorothiazide Hydrochlorothiazide Nu-triazide Tab 50 Mg/25 mg Spironolactone and Hydrochlorothiazide Metoprolol Succinate and Hydrochlorothiazide Teveten Plus Losartan/hctz Valsartan/htcz Zinda-candesartan/hydrochlorothiazide Karvezide PMS-dopazide-25 Tab Prinzide Alembic-telmisartan/hctz PMS-losartan-hctz Mylan-valsartan Hctz
Indication	Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy.[L8447,L8450] Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.[A185138,L8447,L8450,L45663]
Categories	Amides Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Benzothiadiazines Cardiovascular Agents Diuretics Drugs causing inadvertant photosensitivity Genito Urinary System and Sex Hormones Gynecological Antiinfectives and Antiseptics Heterocyclic Compounds, Fused-Ring Hyperglycemia-Associated Agents Hypotensive Agents Increased Diuresis Low-Ceiling Diuretics and Potassium-Sparing Agents Membrane Transport Modulators Natriuretic Agents Nephrotoxic agents Non Potassium Sparing Diuretics OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Substrates Photosensitizing Agents Potential QTc-Prolonging Agents QTc Prolonging Agents Sodium Chloride Symporter Inhibitors Sulfonamides Sulfones Sulfur Compounds Thiazides
ATC-Code	C09BX03 C03AX01 C03AB03 C09DX03 C03EA01 C09DX06 C09XA52 G01AE10 C09DX01 C03AA03 C09XA54 C09DX08 C09DX07
CAS number	58-93-5

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Solute carrier family 12 member 3	MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSST...	unknown	inhibitor
Angiotensin-converting enzyme	MGAASGRRGPGLLLPLPLLLLLPPQPALALDPGLQPGNFSADEAGAQLFA...	unknown	modulator
Calcium-activated potassium channel subunit alpha-1	MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSS...	unknown	inhibitor
Albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown	binder
Solute carrier family 22 member 6	MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR...	unknown	substrate,inhibitor
Organic anion transporter 3	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate
Solute carrier family 22 member 11	MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCW...	unknown	substrate
ATP-binding cassette sub-family C member 4	MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPE...	unknown	substrate
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL435
PubChem	3639
ChEMBL	CHEMBL435
ChEBI	CHEBI:5778
CCDC/CSD	KASMOH, HCSBTZ01, HCSBTZ02, LOLZOE, HCSBTZ08, DADNEE, PIRYAS, HCSBTZ04, DADMUT, HCSBTZ05, CASCAB, NOLCAV, LOLZEU, CASMAL, PIRXUL, EGENIP02, MUPPIX, HCSBTZ03, NOLCEZ, PIRXOF, HCSBTZ06, HCSBTZ07, ODATIX, ODEFEJ, VITWIE, BANPAK, PIRLUZ, EGENOV, SIZZUZ, DADMED, DADMIH, EGENIP, DADMED01, EGENIP01, DADNAA, HCSBTZ, EGENUB, NOLBOI, NOLBOI01, SOBBAP, REZXEZ, EGEPAJ, OBAFIK, HCSBTZ09
COD	2211088, 2206412, 2206455, 2206674, 2206702, 2103079, 4502543, 7216244, 7216241, 7217346, 7217349, 2105753, 2105754, 2105755, 2105756, 2208938, 2209149, 1551861, 1551862, 1551863, 1551864