Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993.[L8717] It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic pain.[A14097,A186179] Gabapentin has some stark advantages as compared with other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism making it unlikely to participate in pharmacokinetic drug interactions.[A186143,A185981,L8717]. It is structurally and functionally related to another GABA derivative, [pregabalin].
Synonyms
Gabapentine
Gabapentino
Gabapentina
Gabapentin
1-(Aminomethyl)cyclohexaneacetic acid
Gabapentinum
Brand Names
Prilopentin -II
Apo-gabapentin Tablets
Fanatrex
Lipritin
Lido GB-300
Ntp-gabapentin
Pendo-gabapentin
Ran-gabapentin
Gabapentin Capsules USP
Nu-gabapentin Capsules
Ipg-gabapentin
Priva-gabapentin
Gabapentin
Van-gabapentin
Gralise
Taro-gabapentin
Topical Nerve Pain
Ratio-gabapentin
Auro-gabapentin
Lipritin II
Gralise Starter Pack
Mylan-gabapentin
Gabapentin Tablets USP
Jamp-gabapentin
Gln-gabapentin
Pentican
Gapeam Budibac
Gabapal
Sig-gabapentin
Prilopentin
Riva-gabapentin
Ag-gabapentin
Dipentocaine Topical Cream Compounding Kit
Gabapentin Kit
Lidotin
Innoprax-5
SmartRx Gaba-V Kit
Mint-gabapentin
Cyclo/Gaba 10/300 Pack
Act Gabapentin
SmartRx Gaba Kit
Gabarone
Gabacaine
GPL Pak
Jamp Gabapentin Capsules
Neurontin
PHL-gabapentin
Dom-gabapentin
Gd-gabapentin
Teva-gabapentin
Nra-gabapentin
Gabapentin Capsules
PMS-gabapentin
Gaba 300-EZS
ACTIVE-PAC with Gabapentin
Auro-gabapentin Tablets
Apo-gabapentin
Mar-gabapentin Tabs
Pro-gabapentin
Bci Gabapentin
Bio-gabapentin
Mar-gabapentin
Therapentin-90
Jamp-gabapentin Tablets
Therapentin-60
Indication
In the United States, gabapentin is officially indicated for the treatment of postherpetic neuralgia in adults and for the adjunctive treatment of partial-onset seizures, with or without secondary generalization, in patients 3 years of age and older.[L8717] In Europe, gabapentin is indicated for adjunctive therapy in the treatment of partial-onset seizures, with or without secondary generalization, in patients 6 years of age and older and as monotherapy in patients 12 years of age and older. It is also used in adults for the treatment of various types of peripheral neuropathic pain, such as painful diabetic neuropathy.[L8732]
Categories
Acids, Acyclic
Acids, Carbocyclic
Amines
Amino Acids
Amino Acids, Peptides, and Proteins
Aminobutyrates
Analgesics
Anti-epileptic Agent
Anticonvulsants
Butyrates
Central Nervous System Agents
Central Nervous System Depressants
Cyclohexanecarboxylic Acids
Cyclohexanes
Cycloparaffins
Decreased Central Nervous System Disorganized Electrical Activity
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
