FOL

FOLIC ACID

Created:	1999-07-08
Last modified:	2011-06-04

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Chemical Details
Formal Charge	0
Atom Count	51
Chiral Atom Count	1
Bond Count	53
Aromatic Bond Count	17

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Chemical Component Summary
Name	FOLIC ACID
Systematic Name (OpenEye OEToolkits)	(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]phenyl]carbonylamino]pentanedioic acid
Formula	C₁₉ H₁₉ N₇ O₆
Molecular Weight	441.397
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(NC(=O)c1ccc(cc1)NCc2nc3c(nc2)NC(=NC3=O)N)CCC(=O)O
SMILES	CACTVS	3.341	NC1=NC(=O)c2nc(CNc3ccc(cc3)C(=O)N[CH](CCC(O)=O)C(O)=O)cnc2N1
SMILES	OpenEye OEToolkits	1.5.0	c1cc(ccc1C(=O)NC(CCC(=O)O)C(=O)O)NCc2cnc3c(n2)C(=O)N=C(N3)N
Canonical SMILES	CACTVS	3.341	NC1=NC(=O)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2N1
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1cc(ccc1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCc2cnc3c(n2)C(=O)N=C(N3)N
InChI	InChI	1.03	InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
InChIKey	InChI	1.03	OVBPIULPVIDEAO-LBPRGKRZSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00158 ?
Name	Folic acid
Groups	vet_approved nutraceutical approved
Description	Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. Folic acid is particularly important during phases of rapid cell division, such as infancy, pregnancy, and erythropoiesis, and plays a protective factor in the development of cancer. As humans are unable to synthesize folic acid endogenously, diet and supplementation is necessary to prevent deficiencies. For example, folic acid is present in green vegetables, beans, avocado, and some fruits.[L5744] In order to function within the body, folic acid must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). This important pathway, which is required for de novo synthesis of nucleic acids and amino acids, is disrupted by anti-metabolite therapies such as [DB00563] as they function as DHFR inhibitors to prevent DNA synthesis in rapidly dividing cells, and therefore prevent the formation of DHF and THF. When used in high doses such as for cancer therapy, or in low doses such as for Rheumatoid Arthritis or psoriasis, [DB00563] impedes the body's ability to create folic acid. This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects. As a result, supplementation with 1-5mg of folic acid is recommended to prevent deficiency and a number of side effects associated with MTX therapy including mouth ulcers and gastrointestinal irritation. [DB00650] (also known as folinic acid) supplementation is typically used for high-dose MTX regimens for the treatment of cancer. Levoleucovorin and leucovorin are analogs of tetrahydrofolate (THF) and are able to bypass DHFR reduction to act as a cellular replacement for the co-factor THF. There are also several antiepileptic drugs (AEDs) that are associated with reduced serum and red blood cell folate, including [DB00564] (CBZ), [DB00252] (PHT), or barbiturates.[A37004] Folic acid is therefore often provided as supplementation to individuals using these medications, particularly to women of child-bearing age. Inadequate folate levels can result in a number of health concerns including cardiovascular disease, megaloblastic anemias, cognitive deficiencies, and neural tube defects (NTDs). Folic acid is typically supplemented during pregnancy to prevent the development of NTDs and in individuals with alcoholism to prevent the development of neurological disorders, for example.
Synonyms	PGA Pteroyl-L-monoglutamic acid Vitamin M Pteroylglutamic acid Folacin ácido fólico Folate sodium Vitamin B9 Folic acid Pteroyl-L-glutamic acid Fols?ure Folate Acidum folicum N-pteroyl-L-glutamic acid Vitamin Bc Pteroyl-L-glutamate N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid PteGlu Acide folique
Brand Names	Ferotrin Folic Acid Injection, USP Quflora Pediatric B-complex 100 Folic Acid Injection USP CitraNatal Bloom DHA Multivit with Fluoride Mvc Noxifol-D Folic-K PM Caps Pnv Ob DHA PreNexa premier Taron BC Tobakient Vital-D Rx Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA ProFola Stress Forte Plus Lipotropic Factors Vimeral Tab Dia-vite Multi Plex II - Tab Vitogen B Stress C Vit E Zinc & Cop Totalvit Plus Bio-b12 Imubolic Vitamin B Complex 50 CompleteNate Chewable Stresstabs + Zinc-copper Se-Plete DHA Adult Infuvite Multiple Vitamins Childrens Chewable Tab Children's Chewable Multi-vitamin Children's Chewable Multi-vitamin Complete With Minerals Folvite-D TriStart DHA Vita Plex Tab Multivitamin with fluoride Children's Chewable Multi Vit W Iron Isotonix Multitech Vitamin Mineral Supplemen Duet DHA Cedevita Sugar-free Vitamin Supplement Isotonix Vitamin B-folic Acid-mineral Supple Virt-Vite Formula Cp Cap Bugs Bunny Chew Multi Vit Plus Iron Renal Caps Dialysis/Stress Vitamin Supplement Twin G.F. Powder Vanilla Flavor Nicotinamide PaxLyte Vitamin B12-folic Acid Viva CT Prenatal Prenate Chewable WesCap-C-DHA Prometa Vol-Tab Rx Revesta Card-floe II Tab Novo-folacid 5mg L.C. Supplement Corvita 150 Vitamin B Compound W Vit C 250mg Tab For Kids Only Chewable Multivitamins Multivitamin & Multimineral Hi Potency Stress B Tension With C BiferaRx Mag-A-folic Tab PNV-First Dialyvite 3000 Vitamin B6 & B12 With Folic Acid Prenatrix Phytopure Nutra-Z TL-Care DHA Multivitamins and Multiminerals Formula Regular Tablet Azesco V & M Vitamin and Mineral Supplement Mvc 9+4 Inj Vita-B-75 Cap Folic Acid 0.4mg VemaVite-PRx 2 with Fish-Based DHA B-Serene Rx Super Pantoplex Vitafol One Nutra Boost Multivitamin with Fluoride AzesChew Complete Multivitamins and Minerals Tablets Timed Release Select OB Sodium Polysulthionate and Folic Acid Neonatal Vitamin Xvite Swiss Total One Virt-Vite Plus Amladex Balanced B-100 Timed Release Irospan 24/6 Kanga-kid Multi-vitamin & Mineral Formula Gly Multi-Vitamin Strovite Forte Caplet Vitafol Nano VitaPhil Aide P.N. Vitamin-mineral Drink Folic Acid Tab 1mg USP Chewable Complete-RF Prenatal Multivitamines Plus Fer Pour Enfants (chewable Tablets) PNV Ferrous Fumarate Docusate Folic Acid Prenatal, DHA OB Complete 400 NewFolic Folic Acid & Vitamin C G.A.S. Complex Gesticare DHA One Daily Vitamin and Mineral Dietary Supplement Pregnancy Multivitamin 50 Plus Thrivite 19 Se-Care Chewable Derma-force Maximum Once A Day Tianshi Vital Powder I Folic Acid-b12 Tab Neutral C + Coenzyme Q10 Plus Vitamins & Minerals Vita-vim - Tab Iron Nutri-Tab OB plus DHA Prenaissance Vinacal TRONVite Balanced B-50 B-complex Vitamins Tab Dalivit Supravite Stress Avec Vit E Et Fer Advanced AM PM Folic Acid 0.4 Mg Tablet NESTABS ABC Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Poly-Vi-Flor Gummies Vitaplex Innersource Tab Stressmates Corvite Free Somavit Brand Vitamins and Minerals Complex Natal PNV Infuvite Pediatric Sandoz Folic Acid Folic Acid NicAzelFORTE Men's Pregnancy Multivitamin Folic 5 Nicadan Calcium PNV L.I.P. Complex Multi Enfants Tab VP-HEME One Prenatryl Prenatal Plus Multivitamin Plus DHA MiniCaps Vigo Multivitamins Drops/lozenge Multiple Vitamins and Minerals Capsules Multi-vitamins Chela Iron Plus C,b Complex Ribotin-E RayaVit WesCap-PN DHA Zatean-Pn Liqui B Complex DaVITE Niaacinamide Azelaic AC TURMER FA B6 Zinc Ox Copper Shen Min Vitamin and Mineral Supplement Super Vita Vim Multivitamins and Minerals Foltx Pnv-dha Vita-folic-B Caps Nu-folic Vitafol Ultra Usana Megavitamin Tablets - Tab Neomultivite Integra Plus RenaPlex VP CH Plus Cool B Vena-Bal DHA Essential Vitamins and Minerals Niferex Elite OB Prenatal Multivitamin Prenate Mini Kindervites Cavan X Multi II IV Vi Tab Stress B Capsules With Vitamin C Marnatal F RE Prenatal Multivitamin with Iron Bal-Care DHA M-Natal Plus Maintain Multiple Vitamin & Minerals Prena1 Vitamin & Mineral Formula 1 Dietary Supplement CitraNatal Rx Moms Choice Rx For Kids Only Chewable Multivit. Plus Iron Folika-D Fizz Multivitamins for Kids W C Loz Leritone Antistress B-complex 50 Folic Acid Inj 5mg/ml USP Focalgin B Ortho Folic WellFola Bacmin Folika-NC Protect Cardio AF Xybiotic Probiotic Support Vitranol healthy mamaBE WELL ROUNDED BE WELL ROUNDED Diaplex Children's Vitamins W Iron Chewable For-2 Virt-PN DHA Folic Acid 1mg With C 20mg Dayavite Genicin Vita-S Iron Plus Manganese, B12, Folic Acid & C Myhephron Dialysis and Stress Supplement Revitalize Multi-vitamin and Mineral Complex Complexe B-75 Cavan Heme OB PureFe Plus Folic Acid 1mg With Vitamin C Folic Acid 400mcg Tab Maxum Multi-vite Bear Essentials Feonyx Formula Cn Multivitamin & Minerals (iron Free) Provida OB Rocky Mountain Multiple Vit and Min Mega Tab Virt-Advance Multiple Vitamins Folic Acid Ctr Srt 800mcg Prim - Royal P.M.T. UltimateCare ONE Children's Chewable Multiple Vitamins With Extra Vitamin C (chewable Tablets) Vitafol Fe Plus Virt-Vite Forte Vyqua Twin Opti Pwr Cavan Alpha Davimet Advanced B & T Formula Dialyvite Supreme D Vasculine TL-Folate Vitamin B-12 With Folic Acid Tablets Mega Plex IV - Pck Zalvit Folivane-OB Sopalamine 3b Plus TL-Icon Animi-3 with Vitamin D Chewable Multivitamins bioJET Liquid B Complex 50 Se-Natal Maxi 10 Tab Vitamin B Complex W C Tab Men's 50+ Vol-Nate CitraNatal Assure Women's Biomultiple Vitamin and Mineral Supplement Supplement De Multivitamines Infusion Arome Fruits Rouges Vita Day Tab Vinate Care Macuzin Multra Plex Hi Potency B Complex W Chelated Minerals Super Stress Mega B Plus 1000mg Vit C Tab Folic Acid Tablets 0.8mg Flintstones Multiple Vitamins Plus Iron Prena1 Plus PrePLUS Childrens Chewable Multiple Vitamins Plus Fe ahoSAN TriStart ONE B 50 Capsules Complete Mega B Prenate Star Folika-T B Complex Tablets Prenavite Forte Tablets Daily-Vite Swiss One Multi Vit & Chel Min Tab Nestabs ONE DuetDHA Complete Folvite Inj 5mg/ml vitaMedMD Rx Plus Multivitamine Multi Vitamin Plus Iron Duet DHA 400 ec Corvite FE Men's Multi Master Formula Formula Int Folivane-Plus with Ascorbic Acid Precursors Pnv-OB-dha Nexa Select Rx Prenatal Vitamin with Plant-Based DHA Focalgin DSS V-Natal Ultimate OB DHA Folic acid Virt-Bal DHA Plus Children's Chewable Vit and Min Tab Durachol Foliflex Macuvex MultiVitamin with Fluoride Relnate DHA Right Choice A.M. Multi Formula - Caplet Vitasure WesTab Mini Tozal CitraNatal Medley B6, B12 & Folic Acid Classic Swiss One 10 Multivitamin and Mineral Tab Abavite VP-Iron-C Plus Women's Formula Onccor Stress Formula Multi-B Comp + 500mg Vit C Cap Chewable Adult Multivitamins With Minerals Potassium W Folic Acid Tab Vita-Rx Diabetic Vitamin Folic Acid With Vitamin B12 and Vitamin C Grand Master Formula Tab Daily Energy Brand B-complex Renate RediChew Trigels-F Forte Vitaflex Dietary Suplement OB Complete Petite Ziphex Cavan Folate OB VIL-Rx Tri-Zel Tianshi Vital Powder III Multivitamines Et Mineraux Junior Regulier Vita Vim Multivitamins and Minerals Tab Re Ob 90 DHA Vitafol Caplet Century Complete PRENATE Restore Replavite Chew.multiple Vits.with Extra C for Children High Potency Multivitamins & Minerals Caplets Taliva FolaPrime Zatean-Pn DHA Ez-flex Natalvirt FLT DermacinRx PureFolix Multiple Vitamins Tab Super Vita-vim With Beta-carotene - Tab Niva-Plus Multi Vitamin - Mineral Cavan One Mega Capsules Mr. Tumee Multi-vitamin Nicomide Trinatal GT Ventrixyl Flinstones Multiple Plus Iron Nicazyme Folplex Se-Tan PLUS Stress B Complex With C, E & Iron Taliment Nicadan ZX Vitaphil 90 DHA TM-Vite RX Vitazyme Folixapure Master Key Multi Vitamin Multi Mineral Formula 2 Methazel Niva-Fol Globucel - Methode Reno Caps Zoo Chews Plus Iron Floradix Formula Liq Homosismin Formula L.G.I. Multiple Vitamins Plus Iron for Women Children's Chewable Multiple Vitamins (chewable Tablets) Concept OB Hi Potency B52 B Complex Tab Stress Formula Vit B With C Complex Virt-PN Bio-fen Acti-folic + Dibencozide Caplets Sulfzix Folic Acid Tab 25mg Trinaz Ortho DF P.R.O. Complex Prenatabs FA Orifer F Multivitamins and Minerals for Women Kid's Choice Children's Chewable Vitamins - Tab Multivitamins and Minerals Tablets Efferlife Multivitamins and Minerals Nutri-Tab OB Floriva Children's Chewable Multiple Vitamins - Tab Folivane-F O-Cal FA multivitamin CitraNatal DHA Reebok Tandem - F M.V.I. Paediatric Iron Vitamins B6,b12,c,folic Acid Tab Vitamin B Complex Tab Zintrexyl-C Am Caps Multicaps NicAzel Vit B Complex Ctr Ocuvel Integra F FerroGels Forte Folvite Tab 5mg WesTab Plus Natalvirt 90dha Children's Chewable Multivitamin Complete With Minerals Nitro Vites - Tab Zatean-Pn Plus Swiss One Multivitamin and Mineral Caplet AxiFol Premium Prenatal Preplus INATAL Ultra Folic Acid Tab 1mg RenaPlex-D B-complex Folica BE Nexa Select Vitrexyl plus Iron Folinex Super B Compound W 500mg Vit C FeRiva FA Divista Timed Release Vita-vim Srt TL-Fluorivite Stress Tab With Zinc, Copper and Vitamin E Liqui B Complex Plus Cedevita Plus Vitamin Supplement Prenate Elite Myferon 150 Forte Vitramyn Folic Acid Plus H.W. Children's Chewable Multi Vit & Mineral Oveeza Virt-Gard Virt-Tabs Folbic Vitamin B Compound Tab Multinate DHA Extra Genicin Vita-Q B-100 Caps Prenatal Vitamins Plus Natafolik Materna - Tab HemeNatal OB plus DHA Vitaphil DHA VitaXyme Prenatal and Post Partum Supplement Virt-PN Plus Prenate DHA WesCaps Stress B Complex With C, E and Iron Tab TriStart FREE Children's Chewable Multivitamin and Multimineral PR Natal 430 ec Multi-12/k1 Pediatric Prenate Essential Senior Multi One Children's Chewable Multiple Vitamins With Iron Tablets (chewable Tablets) UltimateCare ONE NF Dr. AVi MULTIVITAMIN with Zinc, Real Ginger, Lemon and Lemongrass Falessa Methaver Multi-vitamins With Minerals Iron Polysaccharides Folic Acid DHA Cavan Prenatal Fortamines-10 Comprimes M.V.I.-12 Adeks Tablets Vita-Pac Cardiotek-RX Docosavit Prenavite Forte Only One - Tablet Cda-21 Vitamins With Non-medicinal Probiotic Complex Vitamin B + C Cap Stress B&c Tab One A Day Tab Folic Acid 1 mg Multi-actin Hematogen FA Natalvirt Ca Tandem OB Daily Supplement Packs Polymine Avec Zinc Et Cuivre Mi-Omega NF Spectrum 2 Cap Vitabanks Vitamin Tab Avon Nutrivance Vitamin E Plus B Complex 50 Vitamin Cap iFerex 150 Forte Balanced B-50 B-complex Vitamins, Timed Rele Doctor's Choice Brand for Men PR Natal 430 Prenatvite Complete Vp-CH-pnv Neonatal19 Prena1 Chew Prenara Super Kids Chewable Multivitamin Multimineral (chewable Tablets) One A Day Multiple Vit W Minerals PNV Prenatal Vitamin Time Release B 100 Compound - Tablet Re Kar C Plus Children's Chewable Multi Vitamins DuetDHA Balanced Premium Prenatal - Tablets Vege Swiss One Multivitamin W Chel Mins Tab VP-Vite Rx B6, B12 & Folic Acid Multi-vitamin Tablets Bal-Care DHA Essential PreferaOB ONE O-Cal Prenatal Vitamin Orti B Virt-C DHA Balanced B50 Complex Surbex-500 With Iron Nexa Plus C-Nate DHA B-complex Tab Swical-energy 3e Age Multi-kid Strovite One Caplets Se-Tan DHA Virt-Select PRENATAL/POSTNATAL DermaNIC B50 B Complex Tab CitraNatal Harmony Vita Balance 2000 Orange Flavored Crystal Chews Tab Ostachol Viva Kids - Tab Vitamin B Complex Suppl C-B Complex Pregvit Folvite-FE Folcaps One Tablet Daily Mens Formula VITAFOL Gummies FerraPlus 90 Multra With Iron Tl-hem 150 Complete One-A-day - Tab Focalgin 90 DHA Prenate Pixie Provida DHA RE FAC-x tensioSAN FolaMax Xyzbac G Pro Hers Vanilla Vitrexate Central-vite 18 Essential Iron With Vitamins Tab Prenatal Vitamins and Minerals Tablets Iron 25mg With Vit B-cmplx, Vit C, Cu & Mo MVC-Fluoride Spectrum Performa Multivitamins and Minerals Tablets B-complex Tablets Iron, Vit & Min Supp Virt-Care One Fortamines 10 Capsules Fusion Plus Magnum-75 Vitamin and Mineral Supplement Folic Acid 1mg NuFera PNV-Select Concept DHA Calcium Folic Acid Plus D Chewable Escavite Multi #2 Foltrate 24 Multivitamins + Minerals Essential B Tablets Feminex 300 Tab Folic Acid 0.8mg Tandem DHA TriAdvance Tricare Prenatal Body Rox Multi-force for Adults Tab Se-Natal 19 Chela Potassium Plus Flintstones W Extra C Tab Chewable Multiple Vitamins for Children For Kids Only Chewable Multivitamins - Tab DermacinRx Purefoltin Mvc 9 Plus 3 Inj Niron Komplete PNV-Omega Multitam Vitamin B Compound W C Tab 500mg Formula F L W PNV Prenatal Plus Multivitamin Folcal DHA Hemocyte Plus OB Complete Gold B Complex 50+ Caplet Fib-C Melts PR Natal 400 ec Udamin Sp Women's Change Formula Natelle One PureVit DualFe Plus Tricare Prenatal DHA One B-100 Hi Potency B Vitamins Tab Av-VITE FB Forte Formula Hh Multi Vitamin & Minerals Ferrex 150 Forte Plus Stress Complex 600 Avec Vit E Cuivre Zinc Multinate DHA Homosistrol Capsules One A Day Advance Fem Folic Acid 1 Mg - Tablet Nutrol-B-complex PreNexa Tricare Prenatal Compleat Vita Vim With Beta Carotene-caplet FolaMed DHA PNV Prenatal Vitamin Plus Vitamin A B Stress C + Iron & Vite Mini-B Tab Fem Time Tab Phytovim Cap Soluvit N Men's Biomultiple Vitamin and Mineral Supplement Florravite Multiple Vitamins - Tablet Super Multi Stress Formula Multivitamin Tablets USP Bseltzer Stress Formula Choice OB DHA Earthpals Children's Chewables Multi-vitamin & Mineral Tablets E.S.T. Complex Children's Chewable Multi Vitamins With Iron Tablets Folastin Prenavite Tablets Milltrium Senior Vitamin and Mineral Supplement Triveen-PRx RNF Multitabs Folitin-Z Complete One A Day Tab Virt Vite GT Florafol FE Pediatric 0.25 mg/mL Multivitamin and Fluoride Liquid Drops Mebolic Multiple Vitamins Plus Iron - Tab Vp-pnv-dha Formula D.S. Avon Vitadvance Multi-kids Complete Folika-V Ferrex 28 Multiple Vitamins With Iron Folic Acid Capsules 1mg PreGenna Multi Vitamin with Fluoride Novel Vita Complete Multivitamins and Minerals for Children Folcaps Omega-3 B-100 Vitamin Supplement Multivitamins and Minerals With Betacarotene Tablets Venexa FE VirtPrex Animal Shapes Dialyvite with Zinc M.V.I. Adult Materna-tab Rulavite DHA Florafol Pediatric 0.25 mg/mL Multivitamin and Fluoride Liquid Drops Multivitamin Iron Fumarate and Aspartate, Glycinate, Ascorbic Calcium, Vitamin B12, Folic Acid, Calcium Threonate and Succinic Acid B Complex 25mg Vitamin Supplement Revit Plus Cap B-complex With Vitamin C, Biotin, Folic Acid VP CH Ultra Balanced B100 Balanced B 125 Srt Extra Once A Day Virt Nate Vp-heme Ob MaxFe Paramettes Adults Nutrifer Plus Tablets Folic Acid Tab 5mg Multivitamins and Minerals for Men Nephrocaps-QT SetonET KeyFolic Lipo-B-C Tab Hi Potency Multi Tab Foltabs Prenatal Ferralet 90 Osteo-force Vol-Plus Multi B B-Nexa Multi Vitamin-mineral Formula Prenatal Paire OB Plus DHA Prenatal Plus Iron Acide Folique 5 Tab Prenatal Formula Tab Dexatran Carbassist Tablets Fem - Protect Olympian Multi Vit Plus Minerals Tab C. Vit-min Formula Multiple Vitamins With Iron Tablets Multivitamins and Minerals for Young Women Oncovite Extra P.N. Vitamin-mineral Drink Mix Folica-V Poly Vi Flor Chewable Tab Stress B-complex Plus Iron With Vitamins C&e Vitranol Fe Kanga-V Multivitamins & Minerals Hylavite Natavite EnBrace HR Revit Multi-vitamins and Minerals NEONATAL Complete Vitamin B Tablets FeRivaFA Dothelle DHA Dexivite CitraNatal B-Calm Hsn Formula Prenatal Plus PrimaCare OB Complete Prenatal Se-Vate 21/7 EnLyte Super Daily No 2 Supravite Stress Avec Vit E Cuivre Et Zinc PreNatal Vitamins Plus RESTORA Sprinkles TL-Select DHA Prenatal Vitamins Plus Low Iron Nutria Multivitamins and Minerals - Complete Tricare Prenatal DHA One Rx Multivitamin NataFort Childrens Chewable Vitamins Timed Release B-complex 100 Virt-Nate DHA Genicin Vita-D Vita B Complex Tab Folic Acid 0.4mg Dietary Supplement Prenatal Vi-min Folic Acid (1mg Tablet) NovaFerrum Vit-HA Multi Vitamin and Zinc Supplement Sopalamine/3b Plus C Swiss One Daily Balance Tab Folvite CyFolex Foltabs Prenatal Plus DHA Folcaps Care One Energy 80 Prolonged Release Tab Luna Vitamin and Mineral Bar for Women Children's Chewable Multiple Vit.plus Iron Mycelized Childrens Multi-vitamin Liq One Daily VITES Folic Acid Tab 0.4mg USP Vitalife - Capsule PNV Tabs 20-1 Flintstones Multiple Vitamins Tab Folika-MG FE C Tab Plus Zavara Xyzmune Pediatric Infuvite Multiple Vitamins PreTAB Vitachrom Gc NephPlex Rx Multi-force for Women Tab Prenatal Supplement - Tab Fibrik Hypnosom Super Charged Energy Materna PramLyte Trinatal Rx 1 MagneBind 400 Rx Prefera OB plus DHA BioFerr 90 RE Nata OB Folic Acid 800mcg Tab Iron Folate Plus Kids Stuff Tablets Nephron FA Ultimate Tab Thrivite Rx Multi 12 Injection Ply Vi Sol Chewable Tab Av-VITE FB Lorid Ultra Hr Multivitamines Pour Enfants (chewable Tablets) Femitab Tab Multiple Vit Plus Iron Tab Vp-zel Multi-Vitamin With Fluoride WesNate DHA B-50 Complex Folet One Children's Chewable Multivitamins and Minerals Omega-3 Rx Complete Renate DHA Nata Komplete Stress B & C Caplet Formula Ch. Les. PreferaOB plus DHA A/o-26 - Caplet Multi Tabs TL-Fol 500 Roxifol-D Childrens Chewable Multiple Vitamins W.iron Foltamin Chewable Multiple Vitamins Plus Extra C One A Day Advance Adults Total Living Concepts Formula One - Tab Protect Plus SO 60 Vital Be-100 Stress Formula B-comp + 500mg Vit C Tab Vitafol Plus Spd Tab Multi Flow Tablets Adult Formula 50+ Vyo Cylate - Pwr Balanced B-50 Complex Multi-11 Iron Plus Tab Keylosa Virt-Caps Omnivex Corvita Super Stress Capsules B-50 Complex Tab Folivane-PRx DHA RE Nata One-A-day Advance Men's Se-Natal 19 Chewable Great Day/am Formula Tab Complexe B Compose 75 B Compound 50mg Tab PR Natal 400 Iron Folate-F Maxine Vitamin and Mineral Supplement Natural Source Spectrum With Beta Carotene PreferaOB One Quflora Gummies Stress Vitamin B With C Complex Tablets Hematogen Forte Dialyvite SetonET-EC Reliv So Sense Daily Vitamin Supplement Ventrixyl Fe Mega-vim 75 With Beta-carotene - Tablets Chromagen Hemocyte F Natal-V RX Multi-vitamin/Multi-mineral Timed Release B Complex 100 Srt Vinate AZ Vitrexyl Multi-phyto Capsules Ortho D Osteo Formula Bev 29 Tab Envirocomplex Multi-Nate 30 PNV Tabs 29-1 Pro His Mint Prenatal Mega Antioxidant Focalgin CA Multipack II FolaGent DHA Supplement De Vitamines Et Mineraux One-A-day Advance Fem - Tablets Folditam natelle COMPLETE Neonatal Plus Vitamin Mega Plex III - Pck Formula U - Tab Hi Potency Balanced B-100 Complex - Tab WestGel DHA Formula O-care Vitamin and Mineral Supplement Bev B-150 Stress Formula + Iron CitraNatal Harmony 3.0 Hill.vite Dialyvite 5000 Megavite Rx Mnps Formula Supplement Nioxin Recharging Complex Twin G.F. Powder Multivitamines Et Mineraux Reguliers / Regular Multivitamins and Minerals Complexe B 75mg Animi-3 Spark Cap Vita-B B-50 Hi Potency B Vitamins Tab Folet DHA Animal Shapes w/Iron Chewtabs Balanced B-100 B-complex Vitamins Tab Cavan Folate DHA Folite Harvest Of Values All B Complex Tab Liqui Vita Multiple Vitamins and Minerals New Chapter's D'adamo 4 Your Type Multiple for Type O Prenatvite NESTABS Prenatal Multi-vitamin/Mineral Supplement Alkadrenergy Tablets Childrens Chewab Vitamin W Chel Minerals Cifrazol Duet DHA 400 NataChew B.E.T. Complex Q.T. #4 Vitamin and Mineral Dietary Supplement Zingiber Stress Ctr Srt Centratex TL-Select Wellness Formula NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA B-plex Neonatal DHA Super B12 + Folic Acid Stress B With 1000 Mg Vitamin C Kimchi Vitamin chewable multivitamin Jamp-folic Acid Bugs Bunny and Friends Multiple Vitamins Multi Plex I - Tab MultiVitamin with Fluoride Chewable Fem - Control Nutrilite Double X Omniquin Timed Release B-complex 50 FeRiva Iron Aspartate Glycinate and Polysaccharide Complex, Ascorbic Calcium, Vitamin B12, Folic Acid, Calcium Threonate and Succinic Acid Vtb Vitamin and Mineral Supplement Multiple Vitamins & Minerals Tablets Isotonix Advanced B-complex Vitamins With Potassium and Magnesium TriphroCaps Puralor Sun-rype Vitaburst Co-Veratrol Mega Balance N.U.T. Complex Vitrexate FE Recal D Ferrex 150 Forte Palm Springs Multvit and Min Tab Vitafol Vp-heme Ob DHA Tandem Plus PreferaOB Folvik-D Pro Pcos Citrus T.R.I. B-plex Src Vitafol OB Caplet Vc II Childrens Chew Multi Vitamin Tab CitraNatal Essence Hypo Vites Tab Remedient Amerix Multivitamin Hylazinc PreQue 10 Nephrocaps Gestamine Comprimes TL Gard Rx Formula O.C. Se-Natal One Zolate Prenatal Vitamin and Mineral Supplement -tab Corvite 150 Vitamin B12 Plus Tablets W Folic Acid Escavite D Multiple Vitamins Plus Iron Tab Chewable Children's Complete Multivitamins With Essential Minerals Foltrexyl OB Complete DHA Dotremin Prenaissance Plus Co-Balamin Low Potency B Complex Tab Balanced B-complex Vit + Vit C&e Tab Multivitamins for Children Cavan-EC SOD DHA Multi-vitamin Dietary Supplement Venexa Tulivite Multivitamins and Minerals for Young Men Folic Acid Tablets 5mg PureFe OB Plus Edge OB BP Vit 3 Se-Care Conceive A.R.T.H. Away Formula Neonatal Fe Trinatal Ultra MI-Vite RX Stress B Complex With C and E Tab C.R.D.-force Nicotinamide Zcf Zatean-CH Zyvit Complete Natal DHA M.V.I. 12 Pregvit Folic 4 Feminique W Iron and Calcium Tab Extra-Virt Plus DHA Folic D3 Stress Tab With Iron and Vitamin E Zoo Chews Vp-ggr-B6 DermacinRx FoliPlus D FUSION Sprinkles Select-OB Plus DHA Prenatal Supplement Plus DHA Jenliva Nicaprin Q.T. Vitamin and Mineral Drink Mix FaBB One Per Day Vitamin and Mineral Dietary Supplement Hemetab PRENATE Enhance Prenatal Vitamin and Mineral Supplement Tab Ciferex Chewable Multiple Vit Plus Iron for Children Dexifol Vita-vim With Beta-carotene - Tab Chewable Multivitamins Plus Iron One A Day Advance Adults 50+ Nutra-clear Vol-Care Rx CitraNatal 90 DHA Lexazin Corvite Childrens Chewable Multiple Vitamins Homosistrox Capsules B-complex-50 Tab Complex-75 PreNatal 19 Vita-worth B-complex Tablets Pretrate Vitafol-OB Plus DHA Prenatal Supplement Plus DHA WesNatal DHA Complete Vege 1 Daily Tab N.E.U. Complex Citranatal B-calm Triveen-Duo DHA 50 Plus Multiple Vitamins & Minerals HemeNatal OB Cholecal DF Folcyteine Multi Vitamin and Mineral vitamin Sveets Flintstones Multiple Vitamins Active FE Pregvit Folic 5 Swiss One Timed Release Tab Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA Supravite Stress Avec Vit E Multi-12 Pediatric Children's Vitamins Chewable Zavitrol hormaSAN forte Children's Chewable Tab Stress B Complex With C,e, Zinc and Copper CitraNatal Bloom Multi Vitamines - Liq Inatal Advance Prenatvite Plus Tricon Zeldana Mega Vitaminerals Reaphirm Plant Source DHA Xyzbac Childrens Chewable Multiple Vitamins Tab For Men Foltabs 800 FeRiva 21 7 PreGen DHA Kids Stuff With Iron Tablets Prenatal Vitamin and Mineral Supplement P.N.P. Vitamin Drink M.V.I. Pediatric Multi Vitamins & Minerals Formula Inf Tar-end Folgard vitaMedMD One Rx Vitamin B Complex 100 Tab Children's Chewable Multivitamins With Minerals Duet DHA Balanced Infuvite Adult Pnv-VP-U Restora Rx PROTECT IRON Liquid Mega 13 Multivitamin Formula Taron-prex Prenatal Taron-C DHA Active OB K.L. Vitamin-mineral Rogenic Sodium polysulthionate and folic acid Enrich Core Pack - Children Vitamin and Mineral Supplement NicAzel Doxy Kit PreFol-DHA Prenate AM Taron Forte Virt-Nate Stress Formula Tab B-100 Complex Tablets MYNEPHROCAPS DIALYSIS/STRESS Vitamin Supplement Prenatal Plus Vitamins Bentivite Multi Pro
Indication	Folic acid is indicated for the treatment of folic acid deficiency, megaloblastic anemia, and in anemias of nutritional origins, pregnancy, infancy, or childhood.
Categories	Antianemic Preparations Autacoids BCRP/ABCG2 Substrates Biological Factors Diagnostic Agents Diet, Food, and Nutrition Dietary Supplements Drugs that are Mainly Renally Excreted Folic Acid and Derivatives Food Growth Substances Hematinics Hematologic Agents Heterocyclic Compounds, Fused-Ring Micronutrients OAT1/SLC22A6 inhibitors Pteridines Pterins Supplements Vitamin B Complex Vitamin B12 and Folic Acid Vitamins
ATC-Code	B03AE02 B03AD04 V04CX02 B03AD01 B03BB51 B03AD03 B03BB01 B03AE01 B03AD05 B03AD02
CAS number	59-30-3

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Proton-coupled folate transporter	MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHR...	unknown	modulator
Reduced folate transporter	MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITP...	unknown	modulator
Folate receptor gamma	MDMAWQMMQLLLLALVTAAGSAQPRSARARTDLLNVCMNAKHHKTQPSPE...	unknown	binder
Folate receptor beta	MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQ...	unknown	binder
Folate receptor alpha	MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPE...	unknown
Gamma-glutamyl hydrolase	MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKN...	unknown	substrate
Methylenetetrahydrofolate reductase (NADPH)	MVNEARGNSSLNPCLEGSASSGSESSKDSSRCSTPGLDPERHERLREKMR...	unknown	substrate
Dihydrofolate reductase	MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNL...	unknown	substrate
ATP-binding cassette sub-family C member 11	MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNP...	unknown	substrate
ATP-binding cassette sub-family C member 3	MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALP...	unknown	substrate
Solute carrier family 22 member 6	MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR...	unknown	inhibitor
ATP-binding cassette sub-family C member 4	MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPE...	unknown	inhibitor
Broad substrate specificity ATP-binding cassette transporter ABCG2	MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKS...	unknown	substrate
Proton-coupled folate transporter	MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHR...	unknown	substrate
Solute carrier family 25 member 32	MTGQGQSASGSSAWSTVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRF...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682