DMS

DIMETHYL SULFOXIDE

Created:	1999-07-08
Last modified:	2024-09-27

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Chemical Details
Formal Charge	0
Atom Count	10
Chiral Atom Count	0
Bond Count	9
Aromatic Bond Count	0

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Chemical Component Summary
Name	DIMETHYL SULFOXIDE
Systematic Name (OpenEye OEToolkits)	methylsulfinylmethane
Formula	C₂ H₆ O S
Molecular Weight	78.133
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	sulfinyldimethane
SMILES	CACTVS	3.341	C[S](C)=O
SMILES	OpenEye OEToolkits	1.5.0	CS(=O)C
Canonical SMILES	CACTVS	3.341	C[S](C)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	CS(=O)C
InChI	InChI	1.03	InChI=1S/C2H6OS/c1-4(2)3/h1-2H3
InChIKey	InChI	1.03	IAZDPXIOMUYVGZ-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB01093 ?
Name	Dimethyl sulfoxide
Groups	vet_approved approved
Description	A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
Synonyms	Dimetil sulfóxido DMSO Dimethyl sulphoxide Dimethyl sulfur oxide Dimethylsulfoxid Methylsulfinylmethane Dimethyl sulfoxide Diméthylsulfoxyde S(O)Me2 Dimethyli sulfoxidum Sulfinylbis(methane)
Brand Names	Fungizyl AC Dimethyl Sulfoxide Irrigation USP Rimso-50 Kemsol Liquid 70%
Indication	For the symptomatic relief of patients with interstitial cystitis.
Categories	Antioxidants Compounds used in a research, industrial, or household setting Cryoprotective Agents Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Drugs that are Mainly Renally Excreted Free Radical Scavengers Genito Urinary System and Sex Hormones Kinase Inhibitor Miscellaneous Therapeutic Agents Musculo-Skeletal System Protective Agents Solvents Sulfoxides Sulfur Compounds Topical Products for Joint and Muscular Pain Urologicals
ATC-Code	M02AX03 G04BX13
CAS number	67-68-5

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Interleukin-5 receptor subunit alpha	MIIVAHVLLILLGATEILQADLLPDEKISLLPPVNFTIKVTGLAQVLLQW...	unknown	downregulator
Mucin-16	MLKPSGLPGSSSPTRSLMTGSRSTKATPEMDSGLTGATLSPKTSTGAIVV...	unknown	downregulator
Myc proto-oncogene protein	MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQ...	unknown	downregulator
Cytochrome P450 2C19	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV...	unknown	inhibitor
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	inhibitor
Transthyretin	MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAV...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	679
ChEMBL	CHEMBL504
ChEBI	CHEBI:28262
CCDC/CSD	AGEQAF, AGASIL, AFIXIW, AHUVUV, ADISEN, ACESOT, AKAYEQ, ABOMEM, AJEFUS, AKOJAN, ABUFUB, ADIYES, AJIFAC, ACESIN, AKEMAF, ADABUC, ABECES, AKUVEJ, AKOCEK, ACESEJ, ABULAN, AJUXOV, ABEPOQ
COD	2242302, 2018380, 4131301, 7214896