CL6

1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE

Created:	2006-10-26
Last modified:	2021-03-01

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9 entries where CL6 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	42
Chiral Atom Count	0
Bond Count	45
Aromatic Bond Count	23

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Chemical Component Summary
Name	1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE
Synonyms	CLOTRIMAZOLE
Systematic Name (OpenEye OEToolkits)	1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
Formula	C₂₂ H₁₇ Cl N₂
Molecular Weight	344.837
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
Canonical SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
InChI	InChI	1.03	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	InChI	1.03	VNFPBHJOKIVQEB-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00257 ?
Name	Clotrimazole
Groups	vet_approved approved
Description	This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Synonyms	Clotrimazolum 1-(α-(2-Chlorophenyl)benzhydryl)imidazole Clotrimazol 1-(o-Chlorotrityl)imidazole 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole 1-(o-Chloro-α,α-diphenylbenzyl)imidazole Clotrimazole
Brand Names	Betamethasone Clotrimazole Rexall Athletes Foot Canesten Crm 1% Top Fortinia OF Signature Care Athletes Foot Myclo-derm Solution 1% CVS Pharmacy Clotrimazole 3 Kleer-Plex Fungistat Fungus Cure Aptrimazole 1.0% Antifungal Cream Clotrimazole Topical Family Care Clotrimazole Anti-Fungal Cream 1% Leader Athletes Foot Clotrimazole DermacinRx Therazole Pak Fortinia Canesten 2% Vaginal Cream Athletes Foot Canesten Combi 1 Day Internal + External Creams Antifungal Kerasal foot and toe Akin Anti-fungal Au Kah Chuen Antifungal Quality Choice Athletes Foot Clotrimazole-fluconazole Combi Canesten External Cream Equaline Clotrimazole Antifungal Terrasil Rapid-Clear Anti-Fungal Skin Repair Occulus SKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM Pedesil Canesten External Antifungal Cream Smart Sense Athletes Foot Antifungal S-Cream CLOTRIMAZOLE Cream 1% Budpak Antifungal Clotrimazole Myclo Solution Mycelex Family Wellness Antifungal Dynarex Antifungal PRO-EX Anti Fungal Canesten Extra Strength External Antifungal Cream Clotrimaderm Vaginal 3 Forticept Antifungal Foot Gel Terbinafine HCl Chlortimazole and Tolnaftate TerrasilMed ANTIFUNGAL PerfectHeal Antifungal Major Clotrimazole Lotrimin Botanimedix TineaRX Antifungal Drying Emulsion Atopalm Clotrimazole Antifungal CVSHealth Antifungal Antifungal Foot Family Wellness Clotrimazole 1 Anti Fungal Cream Clotrimazole Athletes Foot Terrasil Jock Itch Treatment Maximum Strength Canesten 1% Topical Solution Myclo Crm 10mg Lotriderm Blossom Pharmaceuticals Antifungal Ciclomazole Myclo-gyne Inserts Clotrimazole Cream 1% Taro-clotrimazole/betamethasone Dipropionate Equate Jock Itch CVS Pharmacy ITCH RELIEF ANTIFUNGAL Canesoral Combi 1 Day Myclo Tab 100mg Clotrimaderm Vaginal 6 Clotrimaderm Topical Solution 1% USP Meijer Athletes Foot Cream AF Silka Ringworm TopCare Antifungal Clotrimazole 1% Terrasil Anti-Fungal Treatment MAX TM-Clotrimazole UpandUp Clotrimazole Fungicure Manicure Pedicure Anti Fungal Gehwol med Foot PMS-clotrimazole-betamethasone Fastrin Anti - Fungal Skin Care Anti-Fungal Desenex Fungicure Manicure Pedicure Liquid Gel Shield and Protect Anti-Fungal Meijer Clotrimazole Antifungal Fungicure Pumpspray Clotrimazole Extra Strength External Antifungal Cream Kroger ATHLETES FOOT Canesten 6 Day Internal Cream CVS Antifungal Ringworm Canesten Comfortab 1 Athlete s Foot Afac Mycozyl AC JiDeSheng Dermatin Antifungal Dr Sheffield Athletes Foot TheraPlus Plus First Aid Research Antifungal Cream 1oz Quality Choice Clotrimazole Rite Aid antifungal ringworm Clotrimazol Walgreens Clotrimazole Canesten Combi 1 Day Soft Capsule + Extra Strength External Cream Terrasil Ringworm Treatment MAX Family Care Antifungal Jock-eze Myclo-gyne Cream 1% Soothing Antifungal Cream sunmark Clotrimazole 3 Canesten 3 Day Internal Cream Occulus Skin Hydrating Topical Foam CLO-1 meijer Clotrimazole 3 Our Family Athletes Foot WinCo Foods Antifungal Terrasil Jock-Itch Treatment MAX Aspiera Anti-Fungal Signature Care Antifungal WinCo Antifungal Jock Itch Cream with Clotrimazole Goodsense Athletes Foot Gehwol Fusskraft Nail and Skin Protection Good Neighbor Pharmacy Clotrimazole Healthy Accents Antifungal Myclo-derm Cream 1% Rugby Clotrimazole Antifungal Cream Canesten Combi-pak 1 Day Therapy First Aid Research Antifungal .5oz Canesten 1 Day Internal Cream Live Better Antifungal SIMPLY VITAL Antifungal Cream Sunmark Clotrimazole Kroger Jock Itch Lotrisone Myclo Crm 50mg Votriza-AL Lakesia Antifungal Cream Anti-Fungal Cream CVS Clotrimazole Maximum Strength TopCare Clotrimazole 3 Canesoral Combi Up and Up Athletes Foot Terrasil Tinea Treatment MAX HEB Antifungal MakeSense Terrasil Foot and Nail Anti-Fungal Maximum Strength Canesten Comfortab 3 Smooth Gator Fungus Eliminator Clotrimazole Antifungal Ringworm FungaZoil Advanced Clotrimazole Topical Solution 1% Oheal Ringworm Cream Forticept Antifungal Foot Cream Anti Fungal Jock Itch Clotrimazole Vaginal 6 Good Neighbor Pharmacy Clotrimazole 3 Foot Care Clotrimazole Gehwol Nail Protection Pen Family Care Clotrimazole Antifungal Best Choice Clotrimazole CAREONE Clotrimazole Footlogix Intensive Care Diabetic Formula Fungistat Max Canesten V Pedesil Maximum Strength Canesten 1% Topical Cream Forticept Antifungal Cooling Clotrimazole 1% Athletes Foot meijer Athletes Foot ClotrimazOil Antifungal Hua Tuo Xian Gao ShopRite antifungal Terrasil Antifungal Cream Maximum Strength Clotrimazole/Betameth Canesten 3 Vaginal Tablet Combi-pak Protective Nail and skin Oheal Manuka Honey Eczema Cream Terrasil Anti-fungal Treatment Terrasil Anti-Fungal Treatment Astonea Clotrimazole 1% Athletes Foot Clotrimazole External Cream Signature Care Jock Itch Terrasil Tinea Treatment Maximum Strength Neo-zol Vaginal Cream 1% Clotrimaderm Topical Lotrimin Antifungal Kleer-Plex Fungistat Athlete Foot Cure Fungicure Liquid Gel Walgreens Clotrimazole 3 Hua Tuo Xian Gao Antifungal Exchange Select Atheletes foot Clotrimazol Dual Canesten Combi 1 Day Terrasil Foot and Nail Anti-Fungal Canesten Soft Capsule 1 Walgreens Jock Itch Extra Strength Clotrimazole Extra Fort -fluconazole Combi Neo-zol Cream 1% Walgreens Clotrimazole Antifungal Publix athletic foot Alevazol Athletes Foot Antifungal Antifungal Olp Clotrimazole Up and Up Jock Itch Relief Canesten Combi 3 Day Clotrimazole Jock Itch Terrasil Athletes Foot AntiFungal Treatment Max Gyne-Lotrimin 3 Rexall Jock Itch Clotrimazole Topical Solution USP, 1% Equaline Antifungal Cream Gerlasan Hand Scheinpharm Clotrimazole 1% SoundBody Clotrimazole Antifungal Clotrimazole 1% Topical Antifungal Cream Clotrimaderm-fluconazole Combi-pack Good Sense Athletes Foot antifungal Lucky SuperSoft Athletes Foot Micotrin AC Leader Clotrimazole Anti-Fungal Protective and Moisturizing Skin Cura Hongo Antifungal Femmesil CAREALL Clotrimazole Western Family Athletes Foot Clotrimazole and Betamethasone Dipropionate Gyne-Lotrimin 7 Canesten Liq 1% Rugby Antifungal Clotrimazole Neo-zol Vaginal Cream 2% Clotrimaderm External Cream Zapotol Clotrimazole Clotrimazole Vaginal 3 Canesten 200 Mg Vaginal Inserts Clotrimazole External Antifungal Cream Footlogix Topcare Athletes Foot Fungicure Intensive Jock Itch Clotrimazole Antifungal Shopko Athletes Foot Canesten 1 Vaginal Tablet Combi-pak Canesten 100mg Vaginal Inserts Canesten Crm 1% Vag Clotrimazole Canesten Combi 1 Day Comfortab + Extra Strength External Cream Fungicure Manicure Pedicure 1MED Clotrimazole 1% Antifungal Cream Thera plus Antifungal Clotrimazole Jock Itch Antifungal Canesten Vaginal Inserts 100mg Athlete Foot Cream with Clotrimazole Terrasil JockItch Treatment Maximum Strength
Indication	Topical preparations Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections [F3088], [F3121]: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid [F3121]. Oral preparations The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis [FDA label]. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation [FDA label]. Troche preparations are not indicated for the treatment of any systemic mycoses [FDA label].
Categories	Anti-Infective Agents Anti-Infective Agents, Local Antifungal Agents Antifungal Agents (Vaginal) Antifungals for Dermatological Use Antifungals for Topical Use Antiinfectives and Antiseptics for Local Oral Treatment Azole Antifungals BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strong) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (moderate) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (strong) Cytochrome P-450 CYP3A7 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Gynecological Antiinfectives and Antiseptics Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Imidazole and Triazole Derivatives Imidazole Derivatives Imidazoles OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 inducers P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Steroid Synthesis Inhibitors Stomatological Preparations
ATC-Code	D01AC01 A01AB18 G01AF02 G01AF20
CAS number	23593-75-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
C-X-C chemokine receptor type 2	MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYF...	unknown	modulator
Lanosterol 14-alpha demethylase	MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPL...	unknown	antagonist,inhibitor
Intermediate conductance calcium-activated potassium channel protein 4	MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFG...	unknown	inhibitor
Ergosterol	-	unknown	inhibitor
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown	activator
Hydroxycarboxylic acid receptor 2	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALW...	unknown	partial agonist
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor,inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inhibitor,inducer
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	inhibitor
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	inducer
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	inhibitor,inducer
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B1	MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKS...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B3	MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKI...	unknown	inducer
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682