Ethinylestradiol was first synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering.[A191107] It was developed in an effort to create an estrogen with greater oral bioavailability.[A191107] These properties were achieved by the substitution of an ethinyl group at carbon 17 of [estradiol].[A191107] Ethinylestradiol soon replaced [mestranol] in contraceptive pills.[A191107] Ethinylestradiol was granted FDA approval on 25 June 1943.[L11884]
Synonyms
17-ethinyl-3,17-oestradiol
17-ethinylestradiol
Ethinyloestradiol
Ethynyl estradiol
17alpha-Ethinyl estradiol
Ethinylestradiolum
Ethinylestradiol
17-ethinyl-3,17-estradiol
17¦Á-ethynylestradiol
Etinilestradiol
Ethinyl estradiol
Brand Names
Pirmella 1/35
Ovral 21
Cyestra-35
Ortho Cyclen
Lo-femenal 21 Tablets
Larin 24 Fe
Evra
Tri-lena 21
Sarensis 21
Triphasil 28 Tab
Norethindrone acetate and ethinyl estradiol, and ferrous fumarate
Fayosim
Tri-jordyna 28
Cyonanz
Estinyl Tab 0.05mg
Min-ovral 21 Tab
Aubra
Nymyo
Cyred
Drospirenone and Ethinyl Estradiol Tablets USP 28
Aubra EQ
LoJaimiess
Rhuzdah
Zenchent 0.4/35
Microgestin Fe
Yasmin
Kimidess
MICROGESTIN Fe 1/20
Tri-lena Lo 28
Yasmin Plus
Pirmella 7/7/7
Diane-35
Tri-cyclen Tablets - 28-day
Ortho 10/11 Tablets (28 Day)
Simliya
Tri-jordyna 21
Lo Loestrin Fe
Yasmin 28
Ortho-novum 10/11
Kelnor 1/50
Lo/Ovral-28
Laylaa 21
Levlite
Norgestimate and Ethinyl Estradiol
NuvaRing
Cyred EQ
Jinteli
Levonorgestrel and Ethinyl Estradoil
Centrisa 28
Hailey 1.5/30
Tri-Sprintec
Chateal EQ
Ovcon 35
Synphasic-28 Tablets
Aviane 28
Norgestimate and ethinyl estradiol
Yasmin 21
Microgestin Fe 1/20
Apri 28
Centrisa 21
Necon 777 777
Zarah 28
Cryselle
Yaz
Cl¨¦o -35
Finzala
Vienva Tm
Portia 21
Seasonique
Emoquette
Gemmily
Iclevia
Brevicon 0.5/35 Tablets (28-day Pack)
Tri-VyLibra
Demulen 50 (21 Day Pack)
Kaitlib Fe
Marfem 28
Melodetta 24 Fe
Norethindrone Acetate and Ethinyl Estradiol and Ferrous Fumarate
Taysofy
Zamine 21
EnilloRing
Microgestin 24 Fe
Isibloom
Lo Minastrin Fe
Demulen 50 (28 Day Pack)
LoSeasonique
Nortrel 7/7/7 (28 Day Regimen)
Necon (28 Day Regimen)
Tri-Estarylla
TriNessa Lo
Loestrin 21 1/20
Drospirenone/Ethinyl Estradiol/Levomefolate Calcium and Levomefolate Calcium
Falessa
Nexesta Fe
Aurovela Fe 1/20
Ovima 21
Necon 777
Taro-cyproterone/ethinyl Estradiol
Brevicon 1/35 Tablets (28-day Pack)
Larin Fe 1/20
Tri-Legest Fe 28 Day
Tri-Previfem
Lessina
Lo/Ovral
LOESTRIN Fe 1/20
Aranelle
Cyclafem 7/7/7
Necon 1/35
Ogestrel
Drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium
Desogestrel and Ethinyl Estradiol
Altavera
Lo/ovral-28
Etonogestrel and Ethinyl Estradiol Vaginal
Norethindrone and ethinyl estradiol
Mili
Nikki
Previfem
Chateal
Desogestrel and Ethinyl Estradiol and Ethinyl Estradiol
Tri-cyclen Lo (21 Day)
LOESTRIN 1/20 21 Day
Balcoltra
Synphasic 28 Tablets
Brevicon
Blisovi 24 Fe
Bekyree
Aurovela 1.5/30
Seasonale
Levonest
Triquilar 28
Desogen
Ovral 28tab
Generess
Merzee
Ovcon 50
EluRyng
FEMCON Fe
Levonorgestrel and Ethinyl Estradiol and Ethinyl Estradiol
Zafemy
Lomedia 24 Fe
Drospirenone and Ethinyl Estradiol Tablets USP 21
Tri-cira 28
Vienva
Preven Emergency Contraceptive
HAILEY Fe 1/20
Femynor
Etonogestrel and Ethinyl Estradiol Vaginal Ring
Hailey Fe 1.5/30
Loryna
Teva-cyproterone / Ethinyl Estradiol
Ocella
Ortho 1/35 Tablets (21 Day)
Ayuna
Orsythia
Nordette
Blisovi Fe 1/20
Joyeaux
Loestrin 21 1.5/30
Marlissa
Microgestin
Drospirenone and Ethinyl Estradiol Tablets
Aviane 28 Day
Lo Simpesse
Mono-Linyah
Zovia 1/35
Indayo
Mylan-cyproterone / Ethinylestradiol
Ovral 28 Tablets
Quasense
Evra -(6/0.75)
Apri
Low-Ogestrel
Alesse 21
Junel Fe 24
Loestrin Fe 28 Day
Synphasic 21 Tablets
Zarah
Azurette
Myvlar
Trivora
Freya 28
Levonorgestrel and Ethinyl Estradiol
Introvale
Amethia
Preven Tablets
Ortho 7/7/7 Tablets (21 Day)
Tri-previfem (21 Day)
Drospirenone and Ethinyl Estradiol Tablets 21
Tarina 24 Fe
Microgestin 1.5/30
Tri-Lo- Estarylla
Vyfemla
Linessa 21
Tilia Fe
Xulane
Jasmiel
Ovral 21 Tab
Centrisa Lo 21
Triquilar 21
Tri-lena Lo 21
Ortho Novum 135
Alyacen 1/35
Portia 28
Ortho 7/7/7 Tablets (28 Day)
Aviane
Ortho 0.5/35 Tablets (21 Day)
Mirvala 21
Lo-Zumandimine
Zeosa
Tri-cira Lo 21
Min-ovral 28 Tab
Afirmelle
Zovia 1/35E-28
Ortho Tri Cyclen
Quartette
Jaimiess
Mono-linyah
Quaterna
Aurovela 1/20
Gildess 1.5/30
Cyclen Tablets (21 Day)
Microgestin Fe 1.5/30
Briellyn
Norelgestromin and Ethinyl Estradiol
Sarensis 28
Turqoz
Zarah 21
Caziant
Tri-Linyah
Mercilon
Tri-cyclen Tablets - 21-day
Annovera
Tri-Lo-Sprintec
Reclipsen 21
Tarina Fe 1/20 EQ
Ashlyna
Gianvi
Apri 21
Sprintec
Demulen 30 (28 Day Pack)
Marvelon 21
Lutera 28
Esme 28
Femlyv
Zenchent
Ortho 0.5/35 Tablets (28 Day)
Dasetta 7/7/7
LOESTRIN Fe 1.5/30
Freya 21
Min-ovral 28
Reclipsen
Viorele
Delyla
Hailey 24 Fe
Necon
Apri 28 Day
Reclipsen 28 Day
Tri Femynor
Lybrel
camrese Lo
Demulen 30 (21 Day Pack)
Mibelas 24 Fe
Pimtrea
Leena
Alyacen 7/7/7
Elinest
LOESTRIN 1.5/30 21 Day
Necon 1/35 (28 Day Regimen)
Tri-VyLibra Lo
VyLibra
Estinyl Tablets 0.02 Mg.
Junel FE
Ortho Tri-Cyclen
Select 1/35 (21-day)
Kurvelo
Mircette
Tri-cira Lo 28
Tri-Lo-Mili
Linessa 28
Enpresse
Tri-LO-marzia
Brevicon 1/35 Tablets (21-day Pack)
Kalliga
Brevicon 1/35 21 Tab
Norethindrone and Ethinyl Estradiol and Ferrous Fumarate
Ortho 1/35 Tablets (28 Day)
Lillow
LOESTRIN Fe 1.5/30 28 Day
Lutera
Falmina
Alysena 28
Ortho-cept Tablets (28 Day)
Volnea
Tyblume
Safyral
Ethynodiol Diacetate and Ethinyl Estradiol
Junel Fe 1/20
Ortho Cept
Wymzya Fe
Audrina 28
Cyclessa
Ortho-Novum 777
Larissia
Nylia 7/7/7
Tri-Nymyo
Aviane 21
Gildess 24 Fe
Kelnor 1/35
Rivelsa
Kariva
Ortho 10/11 Tablets (21 Day)
Ortho Evra
Brevicon 0.5/35 21 Tab
Alesse 28
Qismette 28
Syeda
Vienva TM
Portia
Larin 1.5/30
Enskyce
Simpesse
Amethia Lo
Marfem 21
Minivlar 30
Tri-Norinyl
Nortrel 21 Day
Caziant Triphasic Regimen
LOESTRIN Fe 1/20 28 Day
Drospirenone and ethinyl estradiol
Myzilra
Estarylla
Velivet Triphasic Regimen
Triphasil-21
Daysee
Tydemy
Norethindrone and ethinyl estradiol and ferrous fumarate
WYMZYA Fe
Wera
Aurovela 24 Fe
Nortrel 28 Day
Previfem (21day)
Junel 21 Day
Loestrin 24 Fe
Fyavolv
Levora
Junel 1.5/30
Haloette
Modicon
Loestrin 21 Day
Junel Fe 1.5/30
Zenchent FE
Tri-cira 21
Etonogestrel/Ethinyl Estradiol
Setlakin
Norgestrel/Ethinyl Estradiol
Minastrin 24 Fe
Cesia
Minzoya
Reclipsen 28
Twirla
Gildess 1/20
Sronyx
Triphasil 28
Jolessa
ESTROSTEP Fe
Larin Fe 1.5/30
Levonorgetsrel and Ethinyl Estradiol
Mirvala 28
Loestrin 1.5/30
Balziva
Norinyl
Tri-lena 28
Taytulla
Tri-cyclen Lo (28 Day)
Jevantique
Layolis Fe
Ovima 28
Brevicon 1/35 28 Tab
Alysena 21
Drospirenone, Ethinyl Estradiol and Levomefolate Calcium and Levomefolate Calcium
Norethindrone and Ethinyl Estradiol, and Ferrous Fumarate
Tri-Mili
Brevicon 0.5/35 Tablets (21-day Pack)
Blisovi Fe 1.5/30
Qismette 21
Camrese
Zumandimine
Junel Fe 28 Day
TARINA Fe 1/20
Beyaz
Necon 0.5/35
Drospirenone and Ethinyl Estradiol Tablets USP
Nuvaring
MICROGESTIN Fe 1.5/30
Lo-ovral-28
AUROVELA Fe
GENERESS Fe
MonoNessa
Brevicon 0.5/35 28 Tab
Gildess Fe 1/20
Juleber
Drospirenone and Ethinyl estradiol
Femhrt
Lolo
Etonogestrel and Ethinyl Estradiol
Tri-previfem (28 Day)
Desogestrel/Ethinyl Estradiol and Ethinyl Estradiol
Estinyl Tab 0.5mg
Necon 10/11
Nortrel (21 Day Regimen)
Mya
Drospirenone and Ethinyl Estradiol Tablets 28
ORTHO TRI CYCLEN Lo
Select 1/35 (28-day)
Triphasil 21
Rajani
Ortho-cept Tablets (21 Day)
Min-ovral 21
Audrina 21
Zamine 28
Gildess Fe 1.5/30
TriNessa
Dolishale
Dasetta 1/35
Norethindrone Acetate and Ethinyl Estradiol
Norethindrone Acetate and Ethinyl Estradiol, and Ferrous Fumarate
Centrisa Lo 28
Philith
Esme 21
Gildagia
Larin 1/20
Minestrin 1/20
Yaz Plus
Oshih
Amethyst
Lutera 21
Cyclafem 1/35
Drospirenone and Ethinyl Estradiol
Vestura
Norelgestromin and Ethinly Estradiol
Zovia 1/50E-28
Charlotte 24Fe
Solia
Microgestin 1/20
Triphasil 21 Tab
Nylia 1/35
Previfem (28day)
Ortho Novum 1/35
Cyclen Tablets (28 Day)
Marvelon 28
Jevantique Lo
Laylaa 28
Indication
Ethinylestradiol is combined with other drugs for use as a contraceptive, premenstrual dysphoric disorder, moderate acne, moderate to severe vasomotor symptoms of menopause, prevention of postmenopausal osteoporosis.[L11944,L11965,L11947,L11950,L11845,L9806,L11953,L10304,L11956,L11959,L11962]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682