7RXL | pdb_00007rxl

Fab1488 in complex with the C-terminal alpha-TSR domain of P. falciparum

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth L]	C1-set	e7rxlL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
A [auth L]	V-set_3	e7rxlL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
C [auth D]	C1-set	e7rxlD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
C [auth D]	V-set_3	e7rxlD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
B [auth H]	C1-set_1	e7rxlH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
B [auth H]	V-set_12	e7rxlH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
D [auth C]	C1-set_1	e7rxlC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
D [auth C]	V-set_12	e7rxlC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
E	TSP_1	e7rxlE1	A: few secondary structure elements	X: TSP-1 type 1 repeat (From Topology)	H: TSP-1 type 1 repeat (From Topology)	T: TSP-1 type 1 repeat	F: TSP_1	ECOD (1.6)
F	TSP_1	e7rxlF1	A: few secondary structure elements	X: TSP-1 type 1 repeat (From Topology)	H: TSP-1 type 1 repeat (From Topology)	T: TSP-1 type 1 repeat	F: TSP_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
C [auth D]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
B [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
D [auth C]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth L], C [auth D]	Light Chain	IGLV3	Lambda	circumsporozoite protein	SAbDab (2025-05-09)
B [auth H], D [auth C]	Heavy Chain	IGHV3	-	circumsporozoite protein	SAbDab (2025-05-09)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E, F	PF00090	Thrombospondin type 1 domain (TSP_1)	Thrombospondin type 1 domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth L], C [auth D]	Fab1488 light chain	-	-	-
B [auth H], D [auth C]	Fab1488 heavy chain	-	-	-
E, F	Circumsporozoite protein	host cell surface binding binding protein binding heparan sulfate proteoglycan binding proteoglycan binding carbohydrate derivative binding sulfur compound binding	biological process involved in interspecies interaction between organisms symbiont entry into host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell viral process viral life cycle entry into host cell by a symbiont-containing vacuole	cell surface cellular anatomical structure membrane side of membrane cell periphery plasma membrane intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E, F	IPR000884	Thrombospondin type-1 (TSP1) repeat	Repeat
E, F	IPR003067	Plasmodium circumsporozoite protein	Family
E, F	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily	Homologous Superfamily
E, F	IPR051860	Plasmodium Circumsporozoite Invasion Protein	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.