6MC1 | pdb_00006mc1

Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6mc1a_	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d6mc1b_	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d6mc1c1	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d6mc1c2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d6mc1d_	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d6mc1e_	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d6mc1f_	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	(Phosphotyrosine protein) phosphatases II	8081827	3000304	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	(Phosphotyrosine protein) phosphatases II	8081827	3000304	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	(Phosphotyrosine protein) phosphatases II	8081827	3000304	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	(Phosphotyrosine protein) phosphatases II	8081827	3000304	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	(Phosphotyrosine protein) phosphatases II	8081827	3000304	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	(Phosphotyrosine protein) phosphatases II	8081827	3000304	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DSPc	e6mc1A1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: DSPc	ECOD (1.6)
B	DSPc	e6mc1B1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: DSPc	ECOD (1.6)
C	DSPc	e6mc1C1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: DSPc	ECOD (1.6)
D	DSPc	e6mc1D1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: DSPc	ECOD (1.6)
E	DSPc	e6mc1E1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: DSPc	ECOD (1.6)
F	DSPc	e6mc1F1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: DSPc	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00782	Dual specificity phosphatase, catalytic domain (DSPc)	Dual specificity phosphatase, catalytic domain	Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a "recognition" region [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Dual specificity protein phosphatase 10	phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity histone modifying activity histone phosphatase activity catalytic activity histone H2AXS140 phosphatase activity protein serine/threonine phosphatase activity myosin phosphatase activity RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity RNA polymerase II CTD heptapeptide repeat modifying activity phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity histone modifying activity histone phosphatase activity catalytic activity histone H2AXS140 phosphatase activity protein serine/threonine phosphatase activity myosin phosphatase activity RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity RNA polymerase II CTD heptapeptide repeat modifying activity RNA polymerase II CTD heptapeptide repeat phosphatase activity RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity MAP kinase phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity protein tyrosine/serine/threonine phosphatase activity calmodulin-dependent protein phosphatase activity calcium-dependent protein serine/threonine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity protein tyrosine phosphatase activity JUN kinase binding protein binding binding kinase binding enzyme binding protein kinase binding histone H2AXY142 phosphatase activity RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity mitogen-activated protein kinase p38 binding mitogen-activated protein kinase binding MAP kinase serine/threonine phosphatase activity protein tyrosine/threonine phosphatase activity MAP kinase tyrosine phosphatase activity protein tyrosine phosphatase activity, metal-dependent	cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of stress-activated MAPK cascade negative regulation of biological process regulation of cellular response to stress regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication stress-activated MAPK cascade cellular response to stress cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of stress-activated MAPK cascade negative regulation of biological process regulation of cellular response to stress regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication stress-activated MAPK cascade cellular response to stress regulation of intracellular signal transduction response to stress regulation of response to stress intracellular signaling cassette negative regulation of cellular process signal transduction regulation of biological process regulation of signaling negative regulation of response to stimulus biological regulation regulation of stress-activated protein kinase signaling cascade regulation of MAPK cascade negative regulation of signal transduction regulation of stress-activated MAPK cascade stress-activated protein kinase signaling cascade regulation of response to stimulus negative regulation of stress-activated protein kinase signaling cascade MAPK cascade regulation of cell communication cellular process negative regulation of MAPK cascade developmental process fat cell differentiation cellular developmental process regulation of developmental process regulation of cell differentiation regulation of brown fat cell differentiation brown fat cell differentiation cell differentiation regulation of fat cell differentiation tissue regeneration epithelium development regulation of growth regulation of developmental growth developmental growth regulation of epithelium regeneration negative regulation of developmental process growth tissue development regeneration epithelium regeneration negative regulation of developmental growth negative regulation of growth anatomical structure development negative regulation of epithelium regeneration regulation of adaptive immune response immune response immune system process regulation of immune response regulation of immune system process adaptive immune response negative regulation of ERK1 and ERK2 cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade multicellular organismal process negative regulation of locomotion regulation of cell motility tissue migration negative regulation of epithelial cell migration ameboidal-type cell migration regulation of cell migration regulation of multicellular organismal process cell migration epithelial cell migration cell motility regulation of epithelial cell migration locomotion negative regulation of cell migration epithelium migration regulation of locomotion negative regulation of cell motility negative regulation of multicellular organismal process negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation dephosphorylation phosphate-containing compound metabolic process metabolic process phosphorus metabolic process cell development regulation of neurogenesis regulation of gliogenesis regulation of cell development regulation of nervous system development multicellular organism development neurogenesis negative regulation of neurogenesis gliogenesis negative regulation of nervous system development negative regulation of cell differentiation system development regulation of multicellular organismal development regulation of glial cell differentiation nervous system development negative regulation of gliogenesis negative regulation of cell development negative regulation of oligodendrocyte differentiation negative regulation of glial cell differentiation central nervous system development oligodendrocyte differentiation glial cell differentiation regulation of oligodendrocyte differentiation negative regulation of p38MAPK cascade p38MAPK cascade regulation of p38MAPK cascade regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation lymphocyte differentiation positive regulation of T cell differentiation positive regulation of developmental process positive regulation of cell activation T cell activation positive regulation of leukocyte activation T cell differentiation positive regulation of immune system process positive regulation of T cell activation positive regulation of cell development positive regulation of regulatory T cell differentiation regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process leukocyte differentiation positive regulation of biological process positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of hemopoiesis positive regulation of cell differentiation regulation of cell-cell adhesion positive regulation of cellular process regulation of lymphocyte differentiation hemopoiesis positive regulation of cell adhesion regulation of cell adhesion regulation of regulatory T cell differentiation cell activation regulation of T cell activation regulatory T cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation negative regulation of JNK cascade JNK cascade regulation of JNK cascade regulation of immune effector process response to biotic stimulus regulation of respiratory burst involved in inflammatory response respiratory burst involved in defense response response to other organism regulation of innate immune response negative regulation of immune response negative regulation of metabolic process negative regulation of immune effector process response to external stimulus regulation of inflammatory response immune effector process defense response to other organism negative regulation of response to external stimulus respiratory burst involved in inflammatory response negative regulation of defense response negative regulation of respiratory burst involved in inflammatory response inflammatory response regulation of metabolic process regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus negative regulation of response to biotic stimulus negative regulation of inflammatory response negative regulation of respiratory burst innate immune response response to external biotic stimulus regulation of respiratory burst production of molecular mediator involved in inflammatory response defense response defense response to symbiont respiratory burst negative regulation of immune system process negative regulation of innate immune response response to lipid response to oxygen-containing compound response to lipopolysaccharide response to bacterium response to chemical response to molecule of bacterial origin	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR001763	Rhodanese-like domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR000340	Dual specificity phosphatase, catalytic domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
A, B, C, D, E A, B, C, D, E, F	IPR008343	Mitogen-activated protein (MAP) kinase phosphatase	Family
A, B, C, D, E A, B, C, D, E, F	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR036873	Rhodanese-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR020422	Dual specificity protein phosphatase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q9Y6W6	Inflammation acute myeloid leukemia diabetes mellitus IgA glomerulonephritis malignant mesothelioma oligodendroglioma psoriasis amyotrophic lateral sclerosis ductal breast carcinoma in situ MALT lymphoma ovarian cancer tuberculosis Crohn disease gastric carcinoma invasive ductal breast carcinoma Inflammation acute myeloid leukemia diabetes mellitus IgA glomerulonephritis malignant mesothelioma oligodendroglioma psoriasis amyotrophic lateral sclerosis ductal breast carcinoma in situ MALT lymphoma ovarian cancer tuberculosis Crohn disease gastric carcinoma invasive ductal breast carcinoma medulloblastoma pituitary cancer ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.